A5101635374- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Otitis Media and Relapsing Polychondritis
- Vasculitis and related conditions
- Bone and Joint Diseases
- Hip disorders and treatments
- Inflammasome and immune disorders
- Systemic Sclerosis and Related Diseases
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal Disorders and Rehabilitation
- Hematological disorders and diagnostics
- Autoimmune Bullous Skin Diseases
- Hepatitis C virus research
- Neurogenetic and Muscular Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Infectious Diseases and Tuberculosis
- Inflammatory Bowel Disease
- Cerebral Venous Sinus Thrombosis
- Osteomyelitis and Bone Disorders Research
Universidade Unigranrio
2025
Ministério da Saúde
2025
Anhanguera-Uniderp University
2025
Departamento de Epidemiología
2025
Amazon (United States)
2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2013-2024
Universidade de São Paulo
2011-2023
Hospital Universitário da Universidade de São Paulo
2020-2021
Sociedade Brasileira de Ortopedia e Traumatologia
2013
Hospital Geral de Fortaleza
2012
Objective To assess circulating follicular helper T (Tfh)–like CD4+ cells in patients with systemic lupus erythematosus (SLE) and determine their relationship to disease activity. Methods Blood samples from SLE, as well blood Behçet's (BD) healthy individuals controls, were analyzed. In all samples, Tfh‐like enumerated by flow cytometry, using, markers, expression of CXCR5, inducible cell costimulator (ICOS), programmed death 1 (PD‐1) protein, secretion interleukin‐21 (IL‐21). The frequency...
Background Despite the WHO recommendation that 2010–2011 trivalent seasonal flu vaccine must contain A/California/7/2009/H1N1-like virus there is no consistent data regarding its immunogenicity and safety in a large autoimmune rheumatic disease (ARD) population. Methods 1668 ARD patients (systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic sclerosis, psoriatic (PsA), Behçet's (BD), mixed connective tissue disease, primary antiphospholipid...
<h3>Background</h3> Reduced response to pandemic (2009) H1N1 (pH1N1) vaccine in patients with rheumatoid arthritis (RA) was recently reported. <h3>Objectives</h3> To evaluate the contribution of age, disease activity, medication and previous antibody levels this reduced response. <h3>Methods</h3> 340 adult RA 234 healthy controls were assessed before 21 days after adjuvant-free influenza A/California/7/2009 vaccine. Disease activity (DAS28), current treatment pH1N1 titres collected....
The regular practice of physical exercise has been associated with beneficial effects on various pulmonary conditions. We investigated the mechanisms involved in protective effect a model lipopolysaccharide (LPS)-induced acute lung injury (ALI).Mice were divided into four groups: Control (CTR), Exercise (Exe), LPS, and + LPS (Exe LPS). Exercised mice trained using low intensity daily for five weeks. Exe received 200 µg intratracheally 48 hours after last test. measured exhaled nitric oxide...
Sclerostin levels have been reported to be low in ankylosing spondylitis (AS), but there is no data regarding the possible role of this Wnt inhibitor during anti-tumor necrosis factor (TNF) therapy. The present study longitudinally evaluated sclerostin levels, inflammatory markers and bone mineral density (BMD) AS patients under anti-TNF Thirty active were assessed at baseline, 6 12 months after therapy clinical parameters, markers, BMD baseline radiographic damage (mSASSS). age- sex-matched...
Objective. To assess the efficacy and safety of pandemic 2009 influenza A (H1N1) in SLE under different therapeutic regimens. Methods. total 555 patients 170 healthy controls were vaccinated with a single dose non-adjuvanted preparation. According to current therapy, initially classified as No Therapy ( n = 75) 480). Subsequent evaluations included groups monotherapy: chloroquine (CQ) 105), prednisone (PRED) ≥20 mg 76), immunosuppressor (IS) 95) those combination these drugs. Anti-H1N1...
Background: Advances in pathophysiology and treatment of ankylosing spondylitis (AS) was recently demonstrated.However, the effect anti-TNF newly described inflammatory pathways involved pathogenesis this disease remains to be determined.The aim our study was, therefore, investigate long-term influence drugs IL-23/IL-17 axis AS patients their possible correlation with treatment, clinical, laboratory radiographic parameters.Methods: Eighty-six naïve patients, 47 referred for therapy...
Objective. To analyze the clinical effect of enthesitis in a large Brazilian cohort patients with spondyloarthritis (SpA). Methods. A common protocol investigation was prospectively applied to 1505 SpA 29 centers Brazil. Clinical and demographic variables disease indexes were investigated. The Maastricht Ankylosing Spondylitis Enthesitis Score used investigate component. spondylitis most frequent group (65.4%). Others psoriatic arthritis (18.4%), undifferentiated (6.7%), reactive (3.3%),...
Introdução: Arbovírus são vírus transmitidos entre artrópodes e vertebrados, essencialmente para manter seu ciclo de vida. Têm uma distribuição global, prevalecendo em áreas tropicais. Entre as doenças negligenciadas, arboviroses como dengue, chikungunya febre Oropouche destacam-se pela ameaça à saúde pública países desenvolvimento. A é transmitida principalmente pelo mosquito Culicoides paraensis, afetando tanto urbanas quanto silvestres. Seus sintomas incluem alta, cefaleia, mialgia,...
O presente trabalho pretender discutir a importância do atendimento especializado para os pacientes politraumatizados. Trata-se de uma revisão bibliográfica com abordagem qualitativa, em que foram utilizados como motores busca as bases dados Google Scholar, BVS e Scielo seleção dos artigos. Os critérios inclusão artigos português inglês, publicados entre 2020 2025 (últimos 5 anos). exclusão, foram: fora da delimitação temporal linguagem aceita, monografias, teses, dissertações, incompletos...
The aim of this study was to evaluate the influence anti-infliximab (IFX) antibodies on three different points care: response/tolerance IFX, tapering strategy, and in a subsequent treatment with second tumor necrosis factor inhibitor (TNFi).
Estudos recentes relatam as características clínicas e epidemiológicas das espondiloartrites nas populações de diversos países ibero-americanos. O objetivo deste trabalho foi comparar os dados obtidos em um estudo epidemiológico brasileiro com encontrados ibero-americanos, que utilizaram mesmo protocolo investigação. A casuística brasileira apresentou maior frequência pacientes diagnóstico espondilite anquilosante (72,3% brasileiros vs. 57,7% ibero-americanos), estando associada ao sexo...
Objective: To assess reproductive function in male ankylosing spondylitis (AS) patients comparison to healthy controls.Methods: Twenty AS were compared 24 subjects with regard demographic data, urological examination, testicular ultrasound (US), semen analysis, anti-sperm antibodies, and hormone profile. Exclusion criteria present use of sulfasalazine or methotrexate, ever biological/cytotoxic agents. Disease activity was evaluated by clinical laboratory assessments.Results: Demographic data...
Universidade Estadual de Campinas Faculdade Ciencias Medicas Departamento Clinica Medica
Spondyloarthritides (SpA) can present different disease spectra according to ethnic background. The Brazilian Registry of Spondyloarthritis (RBE) is a nationwide registry that comprises large databank on clinical, functional, and treatment data patients with SpA. aim our study was analyze the influence background in SpA patterns series patients.A common protocol investigation prospectively applied 1318 29 centers distributed through main geographical regions Brazil. group comprised whites...