A5102770624- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Enterobacteriaceae and Cronobacter Research
- Infections and bacterial resistance
- Plant Pathogenic Bacteria Studies
- Nosocomial Infections in ICU
- Aquaculture disease management and microbiota
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Escherichia coli research studies
- Antimicrobial Peptides and Activities
- Water Treatment and Disinfection
- Phytochemistry and biological activities of Ficus species
- Bacterial Genetics and Biotechnology
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Phytochemistry and Bioactivity Studies
- Malaria Research and Control
- Bacillus and Francisella bacterial research
Universidad Santiago de Cali
2019-2024
Centro Internacional de Entrenamiento e Investigaciones Medicas
2004-2020
Universidad El Bosque
2017
Hospital Pablo Tobon Uribe
2010
In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC>or=256 microg/ml) and an isolate of Citrobacter freundii reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is first report a KPC-type beta-lactamase identified outside family Enterobacteriaceae.
The plasmid-mediated class A carbapenemase KPC-2 was isolated from unrelated Klebsiella pneumoniae isolates in Medellin, Colombia. These KPC enzymes are the first South America and second isolation outside of United States. expanding geographic spread carbapenemases underscores importance clinical recognition these enzymes.
Ten bla(KPC-2)-harboring Pseudomonas aeruginosa isolates from hospitals located in five different Colombian cities have been characterized. Isolates were multidrug resistant, belonged to pulsotypes, and possessed naturally chromosome-encoded bla(AmpC) bla(OXA-50) genes the acquired bla(KPC-2) gene. In most cases, carried by plasmids of sizes associated with Tn4401b or a new structure containing only part Tn4401 sequence. This study revealed that several clones P. producing are disseminating Colombia.
Carbapenem-resistant Enterobacterales (CRE) pose a significant threat to global public health. The most important mechanism for carbapenem resistance is the production of carbapenemases. Klebsiella pneumoniae carbapenemase (KPC) represents one main carbapenemases worldwide. Complex mechanisms bla KPC dissemination have been reported in Colombia, country with high endemicity resistance. Here, we characterized dynamics gene among CRE infecting and colonizing patients three hospitals localized...
ABSTRACT In 2006, the first isolate of KPC-2-producing Pseudomonas aeruginosa in world was identified Colombia. Recently, similar strains have been reported Puerto Rico. We now report P. Trinidad and Tobago. Surveillance for is warranted, considering their wide geographic spread known association with mobile genetic elements.
The global success of multidrug-resistant Acinetobacter baumannii has been associated with the dissemination a high-risk clone designated clonal complex (CC) 92B (Bartual scheme)/CC2P (Pasteur scheme), which is most frequent genetic lineage in European, Asian, and North American carbapenem-resistant isolates. In these isolates, carbapenem resistance mainly mediated by β-lactamases encoded blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, and/or blaOXA-58-like genes. this study, we...
Pseudomonas aeruginosa is a pathogen that causes healthcare-associated infections (HAIs) worldwide. It unclear whether P. isolated from the natural environment has same pathogenicity and antimicrobial resistance potential as clinical strains. In this study, virulence- resistance-associated genes were compared in 14 genomic sequences of environmental isolates using VFDB, PATRIC, CARD databases. All found to share 62% virulence related adhesion, motility, secretion systems, quorum sensing...
CTX-M-15-producing Escherichia coli has emerged worldwide as an important pathogen associated with community-onset infections, but in South America reports are scarce. We document the presence of E. international ST131 and ST405 clones Colombia present first molecular characterization these isolates America.
Introduction: The continuous evolution of antimicrobial resistance poses a major threat to public health worldwide. Molecular biology techniques have been integrated epidemiological surveillance systems improve the control strategies this phenomenon.Objective: To describe phenotypic and molecular profiles most important Gram negative bacilli from intensive care units in 23 Colombian hospitals during study period 2009-2012.Materials methods: A descriptive was conducted belonging Nosocomial...
This study aimed to evaluate the susceptibility of clinical isolates Enterobacterales and Pseudomonas aeruginosa fosfomycin determine concordance disk diffusion (DD) broth microdilution (BMD) with agar dilution (AD) for testing.The activity against 225 Escherichia coli (n = 64), Klebsiella pneumoniae 68), Enterobacter spp. 28) P. 65) was tested by AD, DD BMD. For DD, results were recorded considering not colonies growing within inhibition halo as recommended CLSI EUCAST, respectively....
We describe the detection of CTX-M-12 beta-lactamase from a clinical isolate Klebsiella pneumoniae in Colombia. Screening nosocomial spp. and Escherichia coli isolates network teaching hospitals revealed presence CTX-M enzymes multiple cities. This is first description
Aeromonas species are renowned enteric pathogens with virulence determinants linked to human diseases, such as gastroenteritis, skin, soft-tissue and muscle infections, septicemia. A recent concern of resistance in this organism has emerged, especially the presence carbapenemases. Herein we describe a case series emerging carbapenem-resistant infection our hospital Cali, Colombia.
ABSTRACT We report the emergence of a novel VIM variant (VIM-24) in Klebsiella pneumoniae isolate Colombia. The displays MICs for carbapenems below resistance breakpoints, posing real challenge its detection. bla VIM-24 gene was located within class 1 integron carried on large plasmid. Further studies are needed to clarify epidemiological and clinical impact.
Antimicrobial resistance reduces the efficacy of antibiotics. Infections caused by multidrug-resistant (MDR), Gram-negative bacterial strains, such as Klebsiella pneumoniae (MDRKp) and Pseudomonas aeruginosa (MDRPa), are a serious threat to global health. However, cationic antimicrobial peptides (CAMPs) promising an alternative therapeutic strategy against MDR strains. In this study, inhibitory activity peptide, derived from cecropin D-like (ΔM2), MDRKp MDRPa clinical isolates, its...
Introduction. Antimicrobial resistance has been identified as one of the major public health problems worldwide. To facilitate its control, bacterial levels must be monitored permanently by effective surveillance systems.Objective. describe antimicrobial patterns Gram negative bacilli in Colombian hospitals over a 3-year period.Materials and methods. This descriptive study used susceptibility profiles provided 14 tertiary-care belonging to Nosocomial Resistance Study Group. The were located...
Background: The dissemination of the uropathogenic O25b-ST131 Escherichia coli clone constitutes a threat to public health. We aimed determine circulation E. strains belonging O25b:H4-B2-ST131 and H30-Rx epidemic subclone causing hospital community-acquired urinary tract infections (UTI) in Colombia. Methods: Twenty-six nonduplicate, CTX-M group-1-producing isolates UTI community were selected for this study. Results: Twenty-two harboring CTX-M-15, one CTX-M-3, three CTX-M-55 identified....
Introduction. Surveillance systems play a key role in the detection and control of bacterial resistance. It is necessary to constantly collect information from all institutions because mechanisms resistance can operate different ways between countries, cities even hospitals same area. Therefore local important order learnabout behaviour design appropriate interventions for each institution. Between January 2003 December 2004, Centro Internacional de Entrenamiento e Investigaciones Médicas...