A5100638994- MicroRNA in disease regulation
- Carbon and Quantum Dots Applications
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- EEG and Brain-Computer Interfaces
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Lung Cancer Research Studies
- Advanced Glycation End Products research
- Hepatitis C virus research
- Hydrogen Storage and Materials
- MXene and MAX Phase Materials
- Advanced X-ray and CT Imaging
- Immune Response and Inflammation
- Nanocluster Synthesis and Applications
University of Electronic Science and Technology of China
2024-2025
Liaoning Cancer Hospital & Institute
2025
China Medical University
2022-2025
Shandong University
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
Zhejiang Chinese Medical University
2022-2024
Renji Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
Chongqing Normal University
2024
Hunan University of Traditional Chinese Medicine
2023-2024
High-mobility group protein box-1 (HMGB1) has recently been recognized as a novel candidate in specific upstream pathway promoting inflammation after brain ischemia. However, its downstream and underlying mechanism have yet to be elucidated. The HMGB1 level the acute cerebral infarct (ACI) was significantly increased compared with that of control group, correlated severity neurologic impairment ACI patients. Further, recombinant human (rhHMGB1) had no effect on microglia derived from mice...
In the present study, we observed expression of toll-like receptor 4 (TLR4) and its downstream signal pathway in peripheral blood monocytes (PBMs) from patients with acute cerebral infarct (ACI). The TLR4 MyD88 by PBMs was determined flow cytometry reverse transcriptase-polymerase chain reaction, nuclear factor-κB (NF-κB) activity detected electrophoretic mobility shift assay. Ischemia/reperfusion injury-induced edema, infarction area, neurologic impairment scores were gene knockout mice....
Multiple myeloma (MM) is an incurable plasma cell malignancy with the hallmark of immunodeficiency, including dysfunction T cells, NK and APCs. Dysfunctional APCs have been reported to play a key role in promoting MM progression. However, molecular mechanisms remain elusive. Here, single-cell transcriptome analysis dendritic cells (DC) monocytes from 10 patients three healthy volunteers was performed. Both DCs were divided into five distinct clusters, respectively. Among them,...
Insulin resistance in obesity is associated with chronic systemic low-grade inflammation. Although it has been shown that Toll-like receptor 4 (TLR4) the liver, muscle and adipose tissue plays an important role obesity-associated inflammation insulin resistance, effect of TLR4 activation intestine not investigated. The aim this study was to explore mouse intestinal TLR4/NF-κB signaling pathway following administration a short-term high-fat diet, as well function local enteric inflammatory...
The bromodomain extra‐terminal (BET) family of proteins are valuable therapeutic targets for cancer and other diseases. adverse events current pan‐BET inhibitors (BETi) make the development BET BD1‐ or BD2‐selective as a fresh avenue to overcome safety challenges. On basis various lysine‐reactive covalent warheads, herein we report set activity‐based probes (ABPs; P3‐P7) capable global profiling ligandable lysines within bromodomains (BRDs) in live cells animals. Chemoproteomic experiments...
Background: Despite the widespread use of dupilumab in atopic dermatitis (AD) treatment, evidence supporting its older patients with intrinsic AD (IAD) versus those extrinsic (EAD) and without comorbidities remains limited. Objective: We aimed to assess clinical efficacy safety treatment elderly IAD EAD comorbidities. Methods: enrolled 113 severe who received for 48 weeks. The inclusion criteria were age ≥60 years Scoring Atopic Dermatitis ≥25. Patients classified as or based on presence...
The histological conversion of lung adenocarcinoma (LUAD) into small-cell cancer (SCLC) is an important resistance mechanism for epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant LUAD. Anlotinib has been recommended as the third-line treatment SCLC patients. efficacy etoposide/platinum (EP) main very limited patients with transformed SCLC. However, little known about EP plus anlotinib present study retrospectively explored clinical response to combined in from...
Although cerebrovascular diseases have been considered as risk factors for cognitive decline and dementia, the associations between atherosclerosis Alzheimer's disease (AD) not fully examined remain controversial. The aim of this three‑year prospective study was to investigate whether arotid artery accelerates impairment in AD patients. association carotid intimal medial thickness (IMT) with trajectories function assessed among 521 patients light moderate AD, 437 were followed up annually 3...
The application of carbon dot (CD) nanomaterials in the agricultural field has shown unique advantages, among which preparing an efficient CD material is key to its popularization and applications. In this work, a biomass (CDs-gl&al) that can be used for improvement plant photosynthesis was prepared. Compared with control, electron transport rate actual photosynthetic efficiency lettuce leaves treated CDs-gl&al increased by 43.5 40.1%, respectively, contents chlorophyll b 23.9 21.0%,...
Endogenous microRNAs (miRNA) in tumors are currently under exhaustive investigation as potential therapeutic agents for cancer treatment. Nevertheless, RNase degradation, inefficient and untargeted delivery, limited biological effect, unclear side effects remain unsettled issues that frustrate clinical application. To address this, a versatile targeted delivery system multiple diagnostic should be adapted miRNA. In this study, we developed membrane-coated PLGA-b-PEG DC-chol nanoparticles...