A5018067682- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Infant Development and Preterm Care
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Infant Health and Development
- Attachment and Relationship Dynamics
- COVID-19 Impact on Reproduction
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Early Childhood Education and Development
- Maternal and Perinatal Health Interventions
- Child Abuse and Trauma
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neonatal Respiratory Health Research
- Cognitive Abilities and Testing
- Grief, Bereavement, and Mental Health
- Fetal and Pediatric Neurological Disorders
- Impact of Technology on Adolescents
- Child Development and Digital Technology
- Epigenetics and DNA Methylation
- Music Therapy and Health
- Child Nutrition and Feeding Issues
- Advanced MRI Techniques and Applications
Tilburg University
2014-2025
Vrije Universiteit Amsterdam
2023
Wayne State University
2016-2018
United States Department of Health and Human Services
2018
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2018
National Institutes of Health
2016
Institute of Developmental Physiology
2012-2014
Institute of Cognitive Neuroscience and Psychology
2014
University of Szeged
2014
KU Leuven
2014
Large-scale functional connectome formation and reorganization is apparent in the second trimester of pregnancy, making it a crucial vulnerable time window development. Here we identified which architectural principles organization are initiated before birth, contrast those with topological characteristics observed mature adult brain. A sample 105 pregnant women participated human fetal resting-state fMRI studies (fetal gestational age between 20 40 weeks). Connectome analysis was used to...
Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, the connectional architecture human brain. Whether these hubs emerge utero, has yet be examined. The current study addresses this question aims determine location neural fetuses. Fetal resting-state fMRI data (N = 105) was used construct connectivity matrices for 197 discrete brain regions. We discovered that within functional organization fetal key are emerging. Consistent with prior...
Abstract Child sleep disorders are increasingly prevalent and understanding early predictors of problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased problems toddlers. We also examined fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent resting-state functional MRI completed questionnaires stress,...
Abstract Functional circuits of the human brain emerge and change dramatically over second half gestation. It is possible that variation in neural functional system connectivity utero predicts individual differences infant behavioral development, but this possibility has yet to be examined. The current study examines association between fetal sensorimotor postnatal motor ability. Resting-state data was obtained 96 healthy fetuses during third trimesters pregnancy. Infant ability measured 7...
Abstract The COVID-19 pandemic affects society and may especially have an impact on mental health of vulnerable groups, such as perinatal women. This prospective cohort study 669 participating women in the Netherlands compared symptoms depression stress during before pandemic. After a pilot 2018, recruitment started 7 January 2019. Up until 1 March 2020 (before pandemic), 401 completed questionnaires pregnancy, whom 250 also postpartum assessment. During pandemic, 268 filled out at least one...
Perinatal depression is common, affecting approximately 7-13% of women. Studies have shown an association between unplanned pregnancy and perinatal depressive symptoms, but many used a cross-sectional design limited postnatal follow-up. The current study investigated the with symptoms using longitudinal cohort that followed women from first trimester until 12 months postpartum. Pregnant (N = 1928) provided demographic clinical data information about intention at trimester. Depressive were...
Maternal anxiety during pregnancy has been consistently shown to negatively affect offspring neurodevelopmental outcomes. However, little is known about the impact of positive maternal traits/states on offspring. The present study was aimed at investigating effects mother’s mindfulness and infant’s neurocognitive functioning 9 months age. Mothers reported using Freiburg Mindfulness Inventory Symptom Checklist (SCL-90) ±20.7 weeks gestation. Event-related brain potentials (ERPs) were measured...
Hyperscanning refers to obtaining simultaneous neural recordings from more than one person (Montage et al., 2002 [[1]Montague P.R. Berns G.S. Cohen J.D. McClure S.M. Pagnoni G. Dhamala M. al.Hyperscanning: fMRI during linked social interactions.Neuroimage. 2002; 16: 1159-1164Crossref PubMed Scopus (441) Google Scholar]), that can be used study interactive situations. In particular, hyperscanning with Electroencephalography (EEG) is becoming increasingly popular since it allows researchers...
Abstract Fetal resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a critical new approach for characterizing brain development before birth. Despite the rapid and widespread growth of this approach, at present, we lack neuroimaging processing pipelines suited to address unique challenges inherent in data type. Here, solve most challenging step, accurate isolation fetal from surrounding tissue across thousands non-stationary 3D volumes. Leveraging our library 1,241...
Abstract While pregnant women are already at-risk for developing symptoms of anxiety and depression, this is heightened during the COVID-19 pandemic. We compared depression symptoms, as indicators psychological distress, before COVID-19, investigated role partner, social network healthcare support on COVID-19-related worries consequently distress. A national survey, conducted first lockdown in The Netherlands, assessed experiences distress (N = 1421), whereas a comparison sample 1439) was...
Continuous positive airway pressure (CPAP) is relatively inexpensive and can be easily taught; it therefore has the potential to optimal respiratory support device for neonates in developing countries.The possibility of implementing bubble CPAP a teaching hospital with large neonatology unit but very limited resources was investigated.A system developed consisting compressor, oxygen concentrator, water bottle control binasal prongs. Neonates birthweights between 1 2·5 kg persistent distress...
Abstract Background The Covid-19 pandemic has put an unprecedented pressure on families with children. How parents were affected by the first lockdown during early postpartum period, already challenging period for many, is unknown. Aim To investigate associations between related stress, mental health, and insensitive parenting practices in mothers fathers young infants Dutch lockdown. Methods Perinatal Experiences (COPE-NL) study included 681 of 0 6 months (572 109 fathers). Parents filled...
Children are confronted with an increasing amount of choices every day, which can be stressful. Decision-making skills may one the most important "21st century skills" that children need to master ensure success. Many aspects decision-making, such as emotion regulation during stressful situations, develop in context caregiver-child interactions. This study examined whether mindful parenting predicts children's individual and social decision-making. The current included 63 mother-child dyads...
Epigenetic changes are associated with altered behavior and neuropsychiatric disorders they modify the trajectory of aging. Maternal anxiety during pregnancy is a common environmental challenge for fetus, causing in DNA methylation. Here, we determined mediating role methylation moderating offspring sex on association between maternal children’s behavioral measures. In 83 mother–child dyads, was assessed each trimester when child four years age. Children’s measures buccal levels (NR3C1,...
Childhood maltreatment (CM) is a potent risk factor for developing psychopathology later in life. Accumulating research suggests that the influence not limited to exposed individual but may also be transmitted across generations. In this study, we examine effect of CM pregnant women on fetal amygdala-cortical function, prior postnatal influences.
During the first COVID-19 lockdown in Netherlands (9 March-1 June 2020), homebirth rate increased from 27 % to 37 among women with low-risk pregnancies starting labour primary midwife-led care (overall population: 15 2020). We explored characteristics and motivations of who change their preference a hospital birth home birth. A nationwide prospective online questionnaire. Questionnaires were distributed during wave (4 April-11 May as well at follow-up (infant ±6 months old). Women pregnant...
Abstract Objectives Maternal anxiety during pregnancy is a risk factor for child behavioral/emotional problems. Knowledge about explanatory factors mediating this link scarce. may be an indicator of adverse postnatal environmental conditions, including maternal and poor parenting, possibly affecting behavior. This study investigated whether mindful parenting in early childhood mediate the association between Methods was based on sample 118 mother-child dyads who participated cohort that...