A5010835285- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Corneal surgery and disorders
- Pituitary Gland Disorders and Treatments
- Visual perception and processing mechanisms
- Ergonomics and Musculoskeletal Disorders
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Advanced Glycation End Products research
- Metabolomics and Mass Spectrometry Studies
- Retinal and Macular Surgery
- Spatial Neglect and Hemispheric Dysfunction
- Single-cell and spatial transcriptomics
- Ophthalmology and Eye Disorders
- Ocular and Laser Science Research
- Optical measurement and interference techniques
- Retinoids in leukemia and cellular processes
- Pectus Deformity Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Immune cells in cancer
- Corneal Surgery and Treatments
Jinan University
2024-2025
Shanghai Eye Disease Prevention & Treatment Center
2019-2024
Shanghai Jiao Tong University
2019-2024
Shanghai First People's Hospital
2019-2024
Centre de recherche Inria Lille - Nord Europe
2023
Institut national de recherche en informatique et en automatique
2023
Yong In University
2021
Peking University
2011
Doheny Eye Institute
2003
Duke University
2002
Diabetic retinopathy (DR) is the leading cause of blindness among working-age population. Although controlling blood glucose levels effectively reduces incidence and development DR to less than 50%, there are currently no diagnostic biomarkers or effective treatments for in glucose-well-controlled diabetic patients (GW-DR). In this study, we established a prospective GW-DR cohort by strictly adhering glycemic control guidelines maintaining regular retinal examinations over median 2-year...
Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness among working-age people. Inflammation recognized as a critical driver DR process. However, main retina-specific cell type producing pro-inflammatory cytokines its mechanism underlying are still unclear. Here, we used single-cell sequencing to identify microglia with metabolic pathway alterations that were source IL-1β in STZ-induced mice. To profile full extent local shifts activated reveal microenvironment...
•Highly myopic eyes with a larger peripapillary atrophy area were more likely to have maculopathy (MAM) and neovascular (MNM).•Highly thicker macular choroidal thickness less MAM MNM.•Highly lower tilt ratio tractional (MTM).•The pathogenesis of MTM is different from that MNM.•A traction component should be considered as possible the classification. PurposeTo investigate characteristics, mergers, risk factors types (MM) in highly population.DesignPopulation-based, cross-sectional...
With the gradual development of display technology, naked-eye 3D technology has gradually come into people's view, and its impact on binocular vision also attracted attention. This study examines efficacy visual perceptual training utilizing in prevention control myopia progression among children. A total 110 children (220 eyes), aged 6 to 12 years, who visited Shenzhen Eye Hospital between April 5, 2023 June 1, 2024, presented with a spherical equivalent (SE) 0 -1.50 diopters (D) following...
Purpose: This study aimed to explore the morphological characteristics of Bruch's membrane opening distance (BMOD), border length (BL), tissue angle (BTA), vertical tilt angle, and peripapillary atrophy (PPA), as well their associations with choroidal thickness (ChT) in young healthy highly myopic eyes. Methods: A total 167 patients high myopia 172 individuals without were enrolled. All subjects divided by axial length. The PPA area was measured on fundus photographs. BMOD, BL, BTA, macular...
Background: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors. Methods: The right eyes 309 participants (75 high myopic, 194 mild-to-moderate 40 healthy) were followed up for 21 months. OCTA images acquired at two visits using follow-up scans. Macular was calculated globally nine early treatment diabetic retinopathy study (ETDRS) subfields macula superficial layer. Results: significantly decreased myopes after a 21-month follow ( p...
Purpose: To explore the characteristics and associated factors of fundus tessellation, especially alternation choroidal thickness among different degrees tessellated in young adults. Design: Cross-sectional, population-based study. Methods: A total 796 students were included study underwent comprehensive ophthalmic examinations, including anterior segment examinations swept-source optical coherence tomography (OCT) measurements. The degree was assessed by photographs applying an early...
Diabetic retinopathy (DR), as the leading cause of vision loss in working-age population, exhibits unique metabolite profiles human plasma and vitreous. However, those retina are not fully understood. Here, we utilized liquid gas chromatography-tandem mass spectrometry technology to explore characteristics streptozotocin (STZ)-induced diabetic mice retina. A total 145 metabolites differed significantly retinas compared with controls. These mainly enriched Warburg effect, valine, leucine...
Objective This study aimed to investigate the influence of peripapillary atrophy (PPA) area and axial elongation on longitudinal changes in macular choroidal thickness (ChT) young individuals with myopia. Methods analysis In this investigation, 431 eyes—342 categorised as non-high myopia (non-HM) 89 HM—were examined for 2 years. Participants were swept-source optical coherence tomography. The ChT, PPA length (AL) measured at baseline follow-up visits. Multiple regression was performed...
To investigate the percentages and risk factors for visual impairment (VI) across age groups in a highly myopic cohort with wide range of (18-93 years).A total 2099 eyes (1220 participants) were enrolled. All participants underwent detailed ocular examinations. Myopic maculopathy (MM) was assessed as atrophy (MAM), traction (MTM) or neovascular (MNM) based on ATN system.Most younger than 50 years had normal vision, while cumulative VI blindness gradually increased after 50-59 years. The...
Purpose: The purpose of this study was to investigate the clinical characteristics paravascular abnormalities (PVAs) and retinoschisis, their associations with choroidal thickness (ChT) in young highly myopic (HM) adults. Methods: A total number 645 eyes were included. Paravascular microfolds (PMs), cystoid spaces (PCs), lamellar holes (PLHs), retinoschisis detected using swept-source optical coherence tomography. Their macular ChT risk factors analyzed. Results: PMs, PCs, PLHs 203 (31.5%),...
Objective To study neck and shoulder work-related muscle fatigue of female sewing machine operators. Methods 18 health operators without musculoskeletal disorders work in Beijing garment industry factory as volunteers participate this study. The maximal voluntary contraction (MVC) 20% MVC bilateral upper trapezium cervical erectors spinae was tested before operations, then the whole 20 time windows (ltime window=10 min) operations monitored surface electromyography( sEMG ) signals...
The aim of this study was to investigate the association between morphological characteristics Bruch's membrane opening distance (BMOD), border length (BL), tissue angle (BTA), peripapillary atrophy (PPA) as well axial (AL) and incident decreased macular choroidal thickness (mChT) in young healthy myopic eyes.A total 323 participants aged 17-30 years were included current 2-year longitudinal study. Each participant underwent detailed ocular examinations at baseline follow-up. Data AL,...
Currently, the exploration of amblyopia treatment methods is gradually shifting to restoration binocular visual perceptual function. Binocular fusion function, as an important component mainly reflects patient's ability integrate signals received from both eyes. In this study, we investigated relationship between function and improvement in acuity during treatment.
A pectoralis major muscle rupture is a rare injury that mainly occurs during exercise. This study examined the application of rehabilitation, strength and passive range motion (ROM) change, subjective assessment for 1 year undertaken after repair surgery in Jiu-Jitsu fighter. We hypothesized ROM exercises rehabilitation strategies contributed to recovery successful return sports. The patient was 34-year-old man who injured falling competitive event. had pain swelling front chest shoulder,...
Background: Diabetic retinopathy (DR) is the leading cause of working-age blindness. Despite controlling blood glucose effectively reduces incidence and development DR, no diagnostic biomarkers or effective treatments for DR in glucose-well-controlled diabetic patients (GW-DR). Here, we explored therapeutic potential ethanolamine GW-DR via a prospective follow-up cohort.Methods: In cohort, formed discovery cohort 209 with baseline healthy eyes. After 2-year follow-up, 71 participants...