Jeff Powis
A5027714342- Hepatitis C virus research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 detection and testing
- Clostridium difficile and Clostridium perfringens research
- Hepatitis B Virus Studies
- Pneumonia and Respiratory Infections
- Primary Care and Health Outcomes
- COVID-19 epidemiological studies
- Infection Control and Ventilation
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Microscopic Colitis
- Patient Satisfaction in Healthcare
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Infection Control in Healthcare
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Emergency and Acute Care Studies
Toronto East General Hospital
2016-2025
University of Toronto
2015-2025
Sunnybrook Health Science Centre
2021-2024
Health Sciences Centre
2021-2024
North York General Hospital
2024
Monash Medical Centre
2024
University Health Network
2021-2024
London Health Sciences Centre
2024
Monash University
2024
Auckland City Hospital
2024
Abstract We enrolled 91 consecutive inpatients with COVID-19 at 6 hospitals in Toronto, Canada, and tested 1 nasopharyngeal swab/saliva sample pair from each patient using real-time RT-PCR for severe acute respiratory syndrome coronavirus 2. Sensitivity was 89% swabs 72% saliva (P = .02). Difference sensitivity greatest pairs collected later illness.
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment uncertain.
The prevalence of multiantimicrobial resistance among Streptococcus pneumoniae continues to increase worldwide. In patients presenting with infection possibly due pneumococci, recognition risk factors that would identify those likely have an antibiotic-resistant isolate might assist clinicians in choosing the most appropriate empirical therapy.A prospective cohort study invasive pneumococcal was conducted Toronto, Canada. Risk for antimicrobial were evaluated by means univariate and...
Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness influenza vaccine for adults has been reported to be lower than younger adults, the impact frailty on (VE) outcomes uncertain. We aimed study VE against hospitalization in focusing frailty.We report trivalent (TIV) people ≥65 years age hospitalized during 2011-2012 season using a multicenter, prospective, test-negative case-control design. A validated index (FI) was used measure...
In 2012/2013, a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) was recommended for immunocompromised adults in the United States and Canada. To assess potential benefits this recommendation, we assessed serotype-specific burden invasive disease (IPD) among individuals.From 1995 to 2012, population-based surveillance IPD conducted Metropolitan Toronto Peel Region, Disease incidence case fatality were measured populations over time, contribution different serotypes...
Direct acting antiviral (DAA) treatments for Hepatitis C (HCV) are now widely available with sustained virologic response (SVR) rates of >90%. A major predictor to DAAs is adherence, yet few real-world studies evaluating adherence among marginalized people who use drugs and/or alcohol exist. This study evaluates patterns and factors associated non-adherence a history drug were receiving care through primary care, community-based HCV treatment program where opiate substitution not offered...
Objective Epidemiological studies present oral crack use as a potential independent risk factor for hepatitis C virus (HCV) status, yet actual HCV transmission pathways via have not been evidenced. To this end, exploratory study sought to detect on crack-use paraphernalia used by street users. Methods Crack-use within 60 min of was collected from 51 (N) street-crack RNA detection conducted through eluate sampling and manual extraction. Participants provided saliva sample test antibody, had...
Abstract Background This study investigated adherence and associated factors among people with recent injection drug use (IDU) or current opioid agonist therapy (OAT) compared once-daily to twice-daily hepatitis C virus (HCV) direct-acting antiviral (DAA) therapy. Methods SIMPLIFY D3FEAT are international, multicenter studies that recruited participants IDU (previous 6 months; SIMPLIFY, D3FEAT) OAT (D3FEAT) between March 2016 February 2017 in 8 countries. Participants received...
Widely available and easily accessible testing for COVID-19 is a cornerstone of pandemic containment strategies. Nasopharyngeal swabs (NPS) are the currently accepted standard sample collection but limited by their need devices sampling trained healthcare professionals. The aim this study was to compare performance saliva NPS in an outpatient setting. This prospective conducted at three centers, which compared samples collected time assessment center visit. Samples were tested real-time...
Abstract We enrolled 53 consecutive in-patients with COVID-19 at six hospitals in Toronto, Canada, and tested one nasopharyngeal swab/saliva sample pair from each patient for SARS-CoV-2. Overall, sensitivity was 89% swabs 77% saliva (p=NS); difference greatest pairs collected later illness.
Abstract Background: Widespread testing for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) is necessary to curb the spread of disease 2019 (COVID-19), but undermined when only option a nasopharyngeal swab. Self-collected swab techniques can overcome many disadvantages swab, they require evaluation. Methods: Three self-collected non-nasopharyngeal (saline gargle, oral and combined oral-anterior nasal swab) were compared SARS-CoV-2 detection at multiple COVID-19 assessment centers...
In patients with invasive pneumococcal disease who have been previously exposed to antibiotics, the time elapsed from end of most recent treatment course appears be important factor predicting antimicrobial resistance.
To assess the cost-effectiveness of six treatment strategies for patients diagnosed with recurrent Clostridium difficile infection (CDI) in Canada: 1. oral metronidazole; 2. vancomycin; 3.oral fidaxomicin; 4. fecal transplantation by enema; 5. nasogastric tube; and 6. colonoscopy.Public insurer all hospital physician services.Ontario, Canada.A decision analytic model was used to costs lifetime health effects each strategy a typical patient experiencing up three recurrences, over 18 weeks....
Diagnosis of influenza in older adults may be complicated by atypical presentations or when patients present with complications an underlying illness. We aimed to identify clinical characteristics and epidemiological factors associated among community-dwelling aged ≥60 years presenting emergency departments.We identified influenza-compatible chief complaints departments six acute care hospitals Ontario, Canada during the 2011/12 2012/13 seasons. Clinical characteristics, medical history...
β-lactam allergy skin testing (BLAST) is recommended by antimicrobial stewardship program (ASP) guidelines, yet few studies have systematically evaluated its impact when delivered at point of care. We conducted a pragmatic multicenter prospective evaluation the use point-of-care BLAST ASPs. In staggered 3-month intervals, ASP teams 3 hospitals received training allergists to offer for eligible patients with infectious diseases receiving nonpreferred therapy due severity their reported...
Background. Clostridium difficile infection (CDI) is the most common cause of nosocomial infectious diarrhea and may result in severe complications including death. We conducted a prospective study to identify risk factors for CDI (cCDI).
We examined frailty as a predictor of recovery in older adults hospitalized with influenza and acute respiratory illness.A total 5011 patients aged ≥65 years were admitted to Canadian Serious Outcomes Surveillance Network hospitals during the 2011/2012, 2012/2013, 2013/2014 seasons. Frailty was measured using previously validated index (FI). Poor defined death by 30 days postdischarge or an increase more than 0.06 (≥2 persistent new health deficits) on FI. Multivariable logistic regression...
Abstract Background The aim of this analysis was to calculate the incidence hepatitis C virus (HCV) reinfection and associated factors among 2 clinical trials HCV direct-acting antiviral treatment in people with recent injecting drug use or currently receiving opioid agonist therapy (OAT). Methods Participants who achieved an end-of-treatment response OAT (SIMPLIFY D3FEAT) enrolled between March 2016 February 2017 8 countries were assessed for reinfection, confirmed by viral sequencing....
Despite high burden of Hepatitis C (HCV) among people who inject drugs, significant barriers to care persist. The aim this study was evaluate the provision rapid, low-barrier point-of-care (POC) HCV RNA testing and linkage clients a supervised consumption service (SCS) located within community health centre in Toronto, Canada. Secondary aims included measuring prevalence at baseline, incidence during follow-up exploring factors associated with positivity treatment uptake.Participants were...