A5062073017- Fixed Point Theorems Analysis
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Neuroscience and Neuropharmacology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Biology and Fertility
- Cancer therapeutics and mechanisms
- Cyclopropane Reaction Mechanisms
- Web Applications and Data Management
- Natural product bioactivities and synthesis
- Atomic and Subatomic Physics Research
- Pulmonary Hypertension Research and Treatments
- Effects and risks of endocrine disrupting chemicals
- Abdominal Trauma and Injuries
- Toxic Organic Pollutants Impact
- Regional Development and Environment
- Mathematical functions and polynomials
- Biopolymer Synthesis and Applications
- Neuroendocrine regulation and behavior
- Plant Reproductive Biology
- Saffron Plant Research Studies
- Advanced Measurement and Detection Methods
- Memory and Neural Mechanisms
- Hops Chemistry and Applications
- Calibration and Measurement Techniques
Nanchang University
2014-2022
University of Hong Kong
2021
Ruijin Hospital
2018
Massachusetts General Hospital
2018
WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered. The authors hypothesized that a sedative-hypnotic screening approach using zebrafish larvae responses sensory stimuli would perform comparably standard assays, and efficiently identify active compounds.The developed binary outcome photomotor response assay...
Multiple morphological abnormalities of the sperm flagella (MMAF) is a characteristic form severe asthenozoospermia and closely related to male infertility. However, it not sure whether intracytoplasmic injection (ICSI) allows MMAF patients reproductive success. The present study reported first case successful injection-embryo transfer (ICSI-ET) in Chinese brothers with novel compound heterozygous mutation FSIP2 (fibrous sheath interacting protein 2), newly identified MMAF-related genes....
We introduce the concepts of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo stretchy="false">(</mml:mo><mml:mi>H</mml:mi><mml:mo>,</mml:mo><mml:mi>ψ</mml:mi><mml:mo>,</mml:mo><mml:mi mathvariant="normal">Φ</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:math>-contraction and probabilistic<mml:math id="M2"><mml:mo stretchy="false">(</mml:mo><mml:mi>α</mml:mi><mml:mo>,</mml:mo><mml:mi>φ</mml:mi><mml:mo mappings in generalized probabilistic metric spaces prove some...
Androgen receptor gene (AR) is essential for male growth and fertility. Its mutations are responsible androgen insensitivity syndrome (AIS) that usually shows the phenotype of azoospermia resulting in infertility. This study reported first case mild AIS with complete normal serum hormones a Chinese family. The proband referred infertility because azoospermia. His uncle two cousins both infertile have Whole-exome sequencing genetic analyses showed carries novel hemizygous AR missense...
In this paper, we introduce the concepts of cyclic weakly (ψ, φ)-contractive mappings and (C, ψ, ϕ)-contractive mappings, prove some fixed point theorems for such two types in complete partially ordered Menger PM-spaces.Some new results are obtained, which extend generalize metric probabilistic spaces.Some examples given to support our results.
Abstract In this paper, we first introduce the concepts of generalized <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>ψ</mml:mi> <mml:mo>,</mml:mo> <mml:mi>f</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mi>λ</mml:mi> </mml:msub> </mml:math> -expansive mappings and <mml:mi>ϕ</mml:mi> <mml:mi>g</mml:mi> <mml:mi>h</mml:mi> -weakly expansive designed for three mappings. Then establish some common fixed point results such two new types...
As a kind of flavonoid, scutellarein is widely used to protect against various human diseases. Although the protective effects have been well studied, its influence on reproduction remains unknown. In this research, we evaluated effect sperm functions in vitro. Three different concentrations (1, 10, 100 μM) were applied ejaculated sperm. Fertilisation-essential functions, as intracellular calcium concentration ([Ca2+ ]i ) and protein-tyrosine phosphorylation, two factors which are vital for...
Ketamine, which used to be widely applied in human and animal medicine as a dissociative anesthetic, has become popular recreational drug because of its hallucinogenic effect. Our previous study preliminarily proved that ketamine could inhibit sperm function by affecting intracellular calcium concentration ([Ca2+]i). However, the specific signaling pathway [Ca2+]i induced is still not clear yet. Here, N-methyl-d-aspartic acid (NMDA) receptor was detected tail region sperm. Its physiological...
Klinefelter syndrome (KS) is the most common sex chromosome abnormality, which occurs in about one 660 newly born males, and it genetic cause of infertility infertile men, accounting for 11%. It rare non-mosaic KS patients to have sperm reproduce naturally, there are currently no reports with normal motile sperm. Microdissection testicular extraction associated intracytoplasmic injection (micro-TESE-ICSI) main assisted reproductive method KS. In this study, we describe a patient (47, XXY)...
In this paper, we introduce a new concept of generalized cyclic -weak contraction mappings and establish some coincidence point results for such in complete partially ordered Menger PM-spaces. Our generalize the main Nashine (Nonlinear Anal. 75:6160-6169, 2012) Gopal et al. (Appl. Math. Comput. 233:955-967, 2014). We also obtain corresponding theorems contractions metric spaces. MSC:47H10, 54H25.
Abstract In this paper, we obtain some Suzuki-type fixed point theorems for generalized mappings in partial cone metric spaces over a solid cone. Our results unify and generalize various known comparable the literature. We also provide illustrative examples support of our new results.
Abstract Study question The patient sperm has normal morphology and motility, which paternal factors cause the abnormal fertilization in IVF/ICSI what is underlying mechanism? Summary answer A genetic mutation of BEX1 decreased PLC-zeta been found patient, may provide novel insights polyspermy pronucleus formation during fertilization. What known already In mammals, formation, a landmark event for fertilization, critical embryonic development. Abnormal refers to number polar bodies zygotes...
A divergent approach to C–C bond forming macrocycle construction is described. Modular sulfonylhydrazone and derived pyridotriazole substrates with three key building blocks have been constructed cyclized afford diverse macrocyclic frameworks. Broad substrate scope functional group tolerance demonstrated. In addition, site-selective postfunctionalization allowed for further diversification of cores.
Abstract In this paper, we introduce the new concepts of multidimensional Menger probabilistic metric spaces and related fixed point for a pair mappings T : $\underbrace{X\times X\times\cdots\times X}_{n}\rightarrow X $ A $X\rightarrow X$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>X</mml:mi> <mml:mo>→</mml:mo> </mml:math> . Utilizing properties triangular norm compatibility with , some common problems hybrid contractions gauge function φ are studied. The obtained...