A5034010149- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Advanced Glycation End Products research
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Retinopathy of Prematurity Studies
- Quinazolinone synthesis and applications
- Musculoskeletal pain and rehabilitation
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- Virus-based gene therapy research
- Eosinophilic Disorders and Syndromes
- PARP inhibition in cancer therapy
- Reproductive System and Pregnancy
- Nanoplatforms for cancer theranostics
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
The University of Texas Health Science Center at Houston
2024
Inje University
2017-2024
Inje University Busan Paik Hospital
2023
Hallym University
2020
Hangang Sacred Heart Hospital
2020
The FDA approval of oncolytic herpes simplex-1 virus (oHSV) therapy underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this promise, the current efficacy oHSV is significantly limited to small subset patients largely due resistance in tumor microenvironment (TME).
Glioblastoma (GBM) remains difficult to treat due poor drug delivery across the blood-brain barrier and an immunosuppressive tumor microenvironment (TME). Tumor-suppressive microRNAs (miRNAs) offer a promising strategy reprogram both cells TME, but inefficient systems limit their clinical application. We previously reported that tumor-suppressive miR-138 regresses growth in preclinical GBM models. Here, we demonstrate trypsin digestion of extracellular vesicles (EVs) enhances labeling...
Background/Aim: Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutation have been shown to a good response erlotinib, tyrosine kinase inhibitor of EGFR. In this study, we found that the death pathways activated by erlotinib in 2D and 3D culture systems are different. Materials Methods: The induced were evaluated flow cytometry immunoblotting both EGFR mutant cells. Results: Treatment caspase 8 activation up-regulation TNF-related apoptosis-inducing ligand...
Epstein-Barr virus (EBV)-associated gastric cancer has been identified as a subtype with definitive clinical and molecular characteristics. Although olaparib, poly ADP ribose polymerase (PARP) inhibitor, is considered potential effective agent for cancer, the effect underlying mechanism of olaparib on depending EBV infection not fully understood.EBV-positive SNU719 EBV-negative SNU638 cell lines were used to identify effects using trypan blue exclusion method annexin V staining assay. To...
Dye eye disease (DED) is a common ocular disorder in patients with diabetes. It has been reported that APX-115A, pan-nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase inhibitor, an apoptosis-inducing effect on Epstein-Barr virus-infected retinal epithelial cells, but its effects DED are poorly understood. Therefore, rat model of diabetes was used the present study to investigate whether APX-115A impact diabetic rats. A established male Sprague Dawley rats via intraperitoneal...
Lung cancer has the highest mortality rate in world, and effective therapies are still required. Cyclooxygenase-2 (COX-2) is highly expressed numerous types of cancer, therefore considered a possible target treatment. Celecoxib, selective COX-2 inhibitor, binding pockets that interact with disrupt its enzymatic activities. In addition, celecoxib able to affect cellular functions COX-2-independent manner. The present study aimed investigate if affected natural killer (NK) cell receptors...
Epstein-Barr virus is a γ-herpes that infects primary B cells and can transform infected into immortalized lymphoblastoid cell lines (LCL). The role of EBV in malignancies such as Burkitt's lymphoma nasopharyngeal carcinoma well understood, however, its EBV-infected retinal remains poorly understood. Therefore, we investigated the effect on growth cells.Previously, established reported line model to address relationship between infection proliferation used adult pigment epithelium (ARPE-19)...
Chronic otitis media with or without cholesteatoma progresses various degrees of bone resorption and remodeling. Estrogen mediates osteoprotective effects through the receptor activator NF-κB ligand (RANKL) pathway, which is mainly mediated by estrogen receptor-alpha (ER-α).The present study investigated expression patterns (RANK), osteoprotegerin (OPG), RANKL, ER-α in pathological tissue from patients chronic to determine roles those factors osteolytic mechanisms underlying pathogenesis...
Background/Aim: Nasopharyngeal carcinoma (NPC), a common cancer in Southern China, is associated with Epstein-Barr Virus (EBV) infection. Although many therapies for NPC have been established, the definite role of EBV remains unclear. Therefore, this work focuses on LMP2A, latent gene, and investigates whether LMP2A related to peroxiredoxin 1 (PRDX1) EBV-positive NPC. Materials Methods: The mRNA protein expression levels PRDX1, beta-catenin were compared patient samples. To identify...
Abstract While an FDA-approved oncolytic herpes simplex-1 virus (oHSV) has shown therapeutic promise with superior safety, accumulating clinical data revealed that its efficacy is observed in a small subset of patients. Here, we show NFκB-mediated Insulin-like Growth Factor 2 (IGF2)/Insulin-like Factor-1 Receptor (IGF1R) signaling pathway as key modulator for oHSV therapy-mediated tumor resistance. RNA sequencing on the oHSV-infected primary glioblastoma (GBM) and breast cancer (BC) cells...
Abstract Therapeutic outcomes in glioblastoma (GBM) patients remain dismal due to its resistance conventional therapies. Tumor-supportive tumor microenvironment (TME) that is educated by cells through immune editing not properly primed for the treatment. Targeted reprogramming of both and tumor-associated macrophages (TAMs) expected prime immunosuppressive TME. Tumor suppressive microRNAs (miRNAs) have been proposed as most suitable therapeutic target perform role. We recently identified...
Abstract While an FDA-approved oncolytic herpes simplex-1 virus (oHSV) has shown therapeutic promise with superior safety, accumulating clinical data revealed that its efficacy is observed in a small subset of patients. Here, we show NFκB-mediated Insulin-like Growth Factor 2 (IGF2)/Insulin-like Factor-1 Receptor (IGF1R) signaling pathway as key modulator for oHSV therapy-mediated tumor resistance. RNA sequencing on the oHSV-infected primary glioblastoma (GBM) and breast cancer (BC) cells...
Abstract Glioblastoma (GBM) is the most aggressive type of primary brain tumors due in part to cell-intrinsic and cell-extrinsic mechanisms. The ability GBM tumor not only resist conventional therapies but also induce an immunosuppressive microenvironment (TME) thought underlie failure immunotherapies. Thus, strategies target both cells immune cells, such as tumor-associated macrophages (TAMs), are great interest. microRNA (miRNA) multiple genes favorable alter character TME cancer cells....
Abstract Glioblastoma (GBM) continues to have a dismal prognosis despite remarkable advances in the field due both tumor-intrinsic factors (i.e., IDH1 or EGFRvIII mutations) and extrinsic relating tumor microenvironment (TME)), necessitating therapeutic innovation. Oncolytic herpes simplex virus-1 (oHSV) is an FDA-approved therapy that has shown promising results clinical trials; however, efficacy limited small subset of patients. Thus, elucidating tumor-TME interplay feedback/feedforward...
Background/Aim: The purpose of our study was to test whether EBV infection affects the response human breast cancer cells nicotine. In addition, underlying signaling mechanisms were evaluated. Materials and Methods: EBV-infected MDA-MB-231 LMP1-transfected established. Reverse transcription-polymerase chain reaction western blotting performed evaluate nicotine receptor expression. To verify functional role mechanism expression induced by infection, morphologic analysis, proliferation...
Purpose: Scar contracture influence the outcome of burn patients significantly.This study aims to investigate feasibility robot-assisted training for lower extremity rehabilitation patients.Methods: This pilot was conducted on 7 8 weeks between January 2019 and November 2019.Two withdrew from this because one had skin abrasion legs which thigh fastening devices were applied other not participate in assessment at 4 after training.Final 5 received gait with SUBAR Ⓡ numeric rating scale (NRS),...
Abstract Purpose: Dye eye syndrome (DE) was common ocular disorders of diabetic patients. Recently, it is reported that APX-115A, pan-NADPH oxidase inhibitor, has an effect on EBV-infected retina epithelial cells, but the effects in DE remains poorly understood. Therefore, investigated whether APX-115A rat models with dry this study. Methods: Diabetic established male Sprague Dawley rats by intraperitoneal injection streptozotocin, and then we treated eyeballs drop solution contained or...