A5058188104- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Sarcoma Diagnosis and Treatment
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Genetic Neurodegenerative Diseases
- Cancer Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Vascular Malformations Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Testicular diseases and treatments
- Neurogenetic and Muscular Disorders Research
- Salivary Gland Tumors Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Caveolin-1 and cellular processes
- Spinal Dysraphism and Malformations
Saitama Medical University
2012-2025
Tokyo Metropolitan Neurological Hospital
2011-2024
John Wiley & Sons (Germany)
2024
Saitama International Medical Center
2020-2022
Nihon University
2007-2021
Tokyo Metropolitan Institute of Medical Science
2021
Ebara Hospital
2014-2020
Nihon University Itabashi Hospital
2010-2016
Alessandro Manzoni Hospital
2016
Centre international de recherche sur le cancer
2005-2008
Glioblastomas are histologically and genetically heterogeneous. We have investigated to what extent histologic features reflect the genetic profile whether they predictive of clinical outcome. Key characteristics, including major cell types (small cell, nonsmall cell), other components such as oligodendroglial components, gemistocytes, multinucleated giant cells, well necrosis microvascular proliferation, 420 cases glioblastoma within a population-based study (1) were reassessed correlated...
Pilocytic astrocytoma (WHO grade I) is a circumscribed, slowly growing, benign that most frequently develops in the cerebellar hemispheres and midline structures occurs predominantly childhood adolescence. In contrast to diffusely infiltrating gliomas adults (e.g. II astrocytomas, oligodendrogliomas), survival of patients with pilocytic excellent after surgical intervention. To search for potential molecular mechanisms underlying its biologic behavior, we compared gene expression profiles...
Multiple system atrophy (MSA) is an adult-onset neurodegenerative disease, which characterized clinically by parkinsonism, cerebellar ataxia and/or autonomic dysfunction, and pathologically alpha-synuclein-related multisystem neurodegeneration, so-called alpha-synucleinopathy, particularly involves the striatonigral olivopontocerebellar systems, with glial cytoplasmic inclusions neuronal cytoplasmic/nuclear (NCIs/NNIs). In recent consensus criteria for diagnosis of MSA, dementia described as...
The histologic characteristics of air space enlargement with fibrosis ( AEF ) are compared usual interstitial pneumonia UIP ), nonspecific NSIP and centrilobular emphysema CLE to determine similarities differences. Lung specimens from 39 patients were studied; 9 , 13 5 identified in lobectomy for cancer 12 cases on surgical lung biopsies. We determined the cystic structures (i.e. abnormal airspace), degree inflammation severity pneumocyte injury semi‐quantitatively. In wall thickness lesions...
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One of the most serious complications cranial radiotherapy is development radiation-induced glioma, which estimated to occur in 1%-4% patients who have received irradiation and has a worse prognosis than sporadic glioblastoma. Although comprehensive genetic analysis recently uncovered molecular characteristics full picture remains unclear due its rarity. A 45-year-old man presented with generalized seizures caused by multiple brain tumors involving right frontal lobe, thalamus, brainstem....
Glioblastoma (GBM) with primitive neuronal component (GBM‐PNC) is a rare GBM subtype recently categorized by the World Health Organization in revised classification system of 2016. Extracranial metastases originating from GBM‐PNC are and metastasis to solid organs has never been reported. Herein, we present first case lung. A 49‐year‐old man presenting headache was diagnosed multiple tumors adhering dura matter right temporal lobe. Despite surgery chemoradiotherapy, 2 months after initial...
We describe a Japanese man with familial amyotrophic lateral sclerosis (ALS) associated p.Cys146Arg mutation in the copper/zinc superoxide dismutase gene (SOD1). The patient developed bulbar signs followed by rapidly progressive limb muscle weakness. prominent clinical feature was orthostatic hypotension due to autonomic failure, which occurred after he underwent tracheostomy 1 year and 3 months onset. Thereafter, required mechanical ventilation progressed communication stage V (totally...
Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder represented by eosinophilic inclusions (EIIs) and GGC/CGG repeat expansion in the NOTCH2NLC gene. We report here two adult cases of NIID, genetically confirmed, with manifestation encephalopathy‐like symptoms address histopathologic findings obtained brain biopsies, focus on “astrocytic” (AIIs). Case 1 presented paroxysmal restlessness, vertigo, or fever was later involved severe dementia tetraparesis. 2...
Our study explored the influence of diet on gliomagenesis and associated systemic effects (SE) in rats. The experimental contained various ingredients supposed to interfere with carcinogenesis, mainly phytochemicals (PtcD for phytochemical diet) its were compared those same without (BD basal diet). Glioma was induced by ethylnitrosourea pregnant females fed diets from start gestation until moment sacrifice offpsrings. In male rats PtcD or BD incidence gliomas markedly reduced a standard...
Obana Y, Sano M, Jike T, Homma T & Nemoto N (2010) Histopathology 56, 372–383 Differential diagnosis of trichosporonosis using conventional histopathological stains and electron microscopy Aims: Although Trichosporon is a causative pathogen white piedra summer‐type hypersensitivity pneumonitis, fatal disseminated cases have recently been increasing. However, often confused with other fungi, especially Candida , in pathological specimens. The aim was to determine the utility for...
Parkinson's disease is now recognized as a major form of α‐synucleinopathy involving both the central and peripheral nervous systems. However, no research has focused on posterior pituitary lobe (PPL), despite fact that this organ also plays an important role in systemic homeostasis. In present study, we aimed to distinguish phosphorylated α‐synuclein (pαSyn)‐positive deposits PPL, observed Lewy body‐ non‐Lewy body‐related disorders. PαSyn were immunohistochemically analyzed using...
Argyrophilic grain (ArG) is the main pathological feature of argyrophilic disease (AGD) and clinically characterized by cognitive impairment, behavioral abnormalities, personality changes, emotional imbalances. However, ArG can not only be found in AGD but also various other neurological disorders, including Parkinson's (PD). The association with psychosis and/or dementia disorders remains unknown; this study, we have investigated PD. distribution degree deposition, spongiform change...
Glioneuronal tumor with neuropil-like islands (GTNI) is featured by "neuropil-like (NIs)" within dominating astroglial components. Isocitrate dehydrogenase (IDH) mutations, particularly IDH1 R132H (G395A), are found in WHO Grade II and III diffuse gliomas as well secondary, but not primary, glioblastomas. We reviewed 5 cases of GTNI, assessed histology immunohistochemistry various antibodies, including those for R132H, direct DNA sequencing G395A. NIs were variable morphology, constantly...
We report the case of a 79-year-old Japanese woman who developed cerebellar ataxia followed by rigidity, dysautonomia and cognitive disorders, was thus clinically diagnosed as having possible MSA with dementia. Neuropathological findings demonstrated not only olivopontocerebellar striatonigral degeneration frequent glial cytoplasmic inclusions (GCIs), but also degenerative changes in parahippocampal region, accentuated anterior portion perirhinal cortex, where neuronal (NCIs) NFTs were...
Glioma‐infiltrating microglia/macrophages are referred to as tumor‐associated macrophages ( TAMs ). Transgenic TG ) rats expressing v ‐ erbB , which is a viral form of the epidermal growth factor receptor, under transcriptional regulation by S100‐ β promoter, develop brain tumors. This study was designed clarify pathological characteristics in these experimental We carried out immunohistochemical and morphometrical analyses tumors (5 malignant glioma, 4 anaplastic oligodendroglioma,...