A5100422347- CAR-T cell therapy research
- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Viral-associated cancers and disorders
- Hemophilia Treatment and Research
- Cancer-related gene regulation
- Parvovirus B19 Infection Studies
- Organic Chemistry Cycloaddition Reactions
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Parasite Biology and Host Interactions
- HIV/AIDS drug development and treatment
- Synthesis and Catalytic Reactions
- Photochromic and Fluorescence Chemistry
- Advanced Vision and Imaging
- Cardiovascular Health and Risk Factors
- MicroRNA in disease regulation
- Neurogenetic and Muscular Disorders Research
- Lipid metabolism and disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Gut microbiota and health
- Acute Lymphoblastic Leukemia research
- Catalytic C–H Functionalization Methods
Zhengzhou University
2018-2025
Henan Provincial People's Hospital
2018-2022
Henan University
2010-2022
Second Xiangya Hospital of Central South University
2012
Central South University
2012
First Affiliated Hospital Zhejiang University
2010
Abstract Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain unclear. Forty-three subjects B-ALL post received CAR-T were analyzed. 34 (79%; 95% confidence interval [CI]: 66, 92%) achieved complete histological remission (CR). Cytokine release syndrome (CRS) occurred 38 (88%; 78, 98%) was ≥grade-3 7. Two died from multiorgan failure CRS....
Abstract Background To evaluate the meaning of serum CRP, ESR, and D-Dimer in diagnosis prosthetic joint infection. Methods In a retrospective study, 101 patients presented with osteoarthritis, PJI, aseptic loosening were divided into three groups according to type operation they received our department from June 2016 December 2018: group A, 44 treated primary arthroplasty; B, 31 PJI resection arthroplasty spacer insertion surgery; C, 26 revision arthroplasty. Data such as gender, age,...
Background: Nowadays, microRNAs (miRNAs) attract much attention in regulating anticancer drug resistance cancers including multiple myeloma (MM). Bortezomib is the first-line choice MM treatment, and bortezomib caused by aberrant DNA repair leads to recurrence therapeutic failure of MM.Objective: Our study aims identify a miRNA that overcomes MM.Methods: We established bortezomib-resistant cell lines, screened several miRNAs have expressions lines. The expression DNA-repair-related proteins...
ABSTRACT Da‐Huang‐Zhe‐Chong Pills (DHZCPs) have demonstrated efficacy in treating uterine fibroids (UFs), but the mechanisms underlying their action remain unclear. In this study, untargeted serum metabolomic analysis was employed to investigate therapeutic effects of DHZCP a rat model UFs utilizing advanced ultra‐performance liquid chromatography tandem quadrupole time‐of‐flight mass spectrometry (UPLC‐Q‐TOF/MS) and pattern recognition. Histopathological examination through H&E staining...
ABSTRACT Background As a medicine‐food fruit, Amomum tsao‐ko has been reported to be beneficial for the management of diabetes. However, its effects and mechanisms in cognitive impairment caused by diabetes remain unclear. This study aimed investigate influences A. on type 2 mellitus (T2DM) mice associated mechanisms. Methods was characterized using UHPLC‐Q‐Orbitrap‐MS/MS. T2DM induced high‐fat diet combined with streptozotocin were treated ethanol extract (EEAT) 8 weeks. The function...
Lactoferrin (LF) is a multifunctional glycoprotein that plays an important role in native immune defense against infections, including human herpetic viruses, such as cytomegalovirus and herpes simplex virus types 1 2. However, its anti-Epstein-Barr (EBV, γ-herpesvirus) function has not been reported the literature. EBV widespread all populations believed to be linked tumorigenesis, lymphomas nasopharyngeal carcinoma (NPC). We previously LF expressed significantly lower level NPC tissues was...
Abstract Intertrochanteric fractures (ITFs) in the elderly are still a big challenge for clinical doctors. Although proximal femoral nail antirotation (PFNA) and bipolar hemiarthroplasty (BPH) selected by most of orthopaedic surgeons ITFs patients, there is no consensus on superiority PFNA BPH elderly. In this study, we hypothesized that should not be as primary option analyzed data 202 patients aged 80 years or more treated with (Group A) B) to compare early outcome more. We found operation...
Trichinella spiralis is a major foodborne parasite worldwide. After the encapsulated muscle larvae (ML) in meat are ingested, ML liberated stomach of host and activated into intestinal infectious (IIL), which develop adult worm after molting four times. A novel glutamine synthetase (TsGS) was identified from T. IIL at 10 h post-infection, but its biological role life cycle not clear. The aim this study to investigate characteristics TsGS functions larval acid resistance, molting,...
With 2-octyl dithieno[2,3-b:3,2-d]thiophene as raw material, three steps including formylation, McMurry reaction and photocylization were employed to generate dioctyl-hexathia[7]heterohelicene in total yield of 29.9. The crystal analysis shows that some short intermolecular interactions S...S C...S observed the target compound. Keywords: dithieno[2,3-b:3',2'-d]thiophene, dioctyl-hexathia[7]heterohelicene, heterohelicene, synthesis, photocylization, structure
At present, there are no effective methods for the treatment of hemophilia B, and it has high mortality disability. Therefore, is very important carriers to carry out genetic counseling make prenatal diagnosis. In this study, we made gene diagnoses in a family with novel F9 mutation, report mutation.All exon sequences flanking were analyzed by Sanger sequencing proband; then according mutation proband, was performed on members. Based above results, pathogenic finally identified, which used...
Abstract Introduction Current treatment of severe haemophilia A includes prophylaxis with factor VIII (FVIII) replacement. The supply plasma‐derived FVIII is short in China. Purpose To evaluate the efficacy and safety a new B‐domain deleted (BDD) recombinant (TQG202) produced by human‐derived cells for patients compare bioequivalence Xyntha. Methods This multicentre, clinical trial consisted an open‐label, randomized, two‐period cross‐over assessing single‐dose pharmacokinetics (PK),...
Abstract With the increasing popularity of high‐resolution displays, there is a growing demand for more realistic rendered images. Ray tracing has become most effective algorithm image rendering, but its complexity and large amount computing data require sophisticated HPC solutions. In this article, we present our efforts to port ray engine CYCLES Blender new generation Sunway supercomputers. We propose optimizations that are tailored hardware architecture, including multi‐level parallel...
Epstein-Barr virus-associated monomorphic post-transplant lymphoproliferative disorder after pediatric kidney transplantation: A case report
Objective: To reveal the related factors of inhibitors and differences ofhemorrhage joint disease before after production in children with hemophilia A (HA) . Methods: Retrospective analyses clinical data 381 HA under age 16 registered Registration Management Center Hemophilia Henan Provincial from January 2015 to August 2018. Results: total were enrolled 116 (30.4%) mild, 196 (51.4%) moderate, 69 (18.1%) severe cases; 54 patients (14.2%) had inhibitors, including 22 high 32 low titer...
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Background: Allogeneic chimeric antigen receptor T (CAR-T) cells receive activation signals from both cell receptors (TCR) and CARs, which may possess stronger activity in anti-leukemia cells. However, the safety efficacy of donor-derived CAR-T treating relapsed patients with B-cell acute lymphoblastic leukemia (B-ALL) after allo-HSCT are not yet clear.Methods: Relapsed CD19-positive B-ALL this respective study received CD19.CAR-T treatment. The long-term outcomes that related to...