A5067183713- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Angiogenesis and VEGF in Cancer
- Myofascial pain diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Photoreceptor and optogenetics research
- Lipid Membrane Structure and Behavior
- Tendon Structure and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Hormonal Regulation and Hypertension
- Nerve injury and regeneration
- Chemical Synthesis and Analysis
- Apelin-related biomedical research
- Body Contouring and Surgery
- Axon Guidance and Neuronal Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Parkinson's Disease Mechanisms and Treatments
University of Padua
2016-2025
University of Bari Aldo Moro
2006-2022
Neuroscience Institute
2021
Weatherford College
2010-2019
Karolinska Institutet
2006-2014
University of Modena and Reggio Emilia
1985-2010
University of Turin
2006
National Institute on Drug Abuse
2006
Universitat de Barcelona
2006
AULSS 2 Marca Trevigiana
2006
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence GPCR-GPCR interactions in coordinated and cooperative manner. However, despite current development techniques for large-scale detection GPCR heteromers, order to understand their connectivity it is necessary develop novel tools study global heteroreceptor networks. To provide insight into overall topology heteromers identify...
Abstract Background Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety toxicological effects is well supported animals, including testicular toxicity male infertility. For these reasons, the understanding epidemiological associations molecular mechanisms involved endocrine-disrupting properties PFCs on human reproductive health a major concern. Objective To investigate relationship...
It is widely recognized that extracellular vesicles subserve non-classical signal transmission in the central nervous system. Here we assess if astrocyte processes, are to play crucial roles intercellular communication at synapses and neuron-astrocyte networks, could convey messages through vesicles. Our findings indicate, for first time freshly isolated processes prepared from adult rat cerebral cortex, can indeed participate system by releasing exosomes volume might target near or...
Mesenchymal stem cells (MSCs) prevent the onset of bronchopulmonary dysplasia (BPD) in animal models, an effect that seems to be mediated by their secreted extracellular vesicles (EVs). The aim this study was compare protective effects intratracheally (IT) administered MSCs versus MSC-EVs a hyperoxia-induced rat model BPD. At birth, rats were distributed as follows: animals raised ambient air for 2 wk ( n = 10), and exposed 60% oxygen treated with IT-administered physiological solution or...
Articular cartilage has a very limited self-repairing capacity; thus, chondral lesions normally result in chronic degeneration and, eventually, osteoarthritis development. Currently, tissue engineering offers new tool for the clinical treatment of osteochondral defects. The present investigation aimed to develop an vitro engineered using class semisynthetic scaffolds. Two nonwoven meshes hyaluronan esters (Hyaff(R) derivatives) were seeded with sternal chick embryo chondrocytes cultured up...
The effect of the intraarticular sodium hyaluronate (HA) injection on osteoarthritic knee joint has been evaluated in dogs using an experimental model osteoarthritis induced by sectioning anterior cruciate ligament. Seven weeks after surgery, damage, graded according to Mankin's scale, was significantly reduced joints treated with HA from second week postsurgery compared untreated joints. When therapy initiated seventh week, progression still controls. Both morphology and morphometry showed...
Previous studies have shown that increased vascularity is associated with haematogenous metastasis and poor prognosis in gastric cancer. The role of mast cells cancer angiogenesis has not been clarified completely. In this study, we correlated microvascular density tryptase- chymase-positive histopathological type Specimens primary adenocarcinomas obtained from 30 patients who had undergone curative gastrectomy were investigated immunohistochemically by using anti-CD31 antibody to stain...
The regulation of the balance between proliferation and differentiation in mesenchymal compartment lung is largely uncharacterized, unlike its epithelial counterpart. In this study, we determined that miR-142-3p contributes to proper progenitors by controlling level WNT signaling. can physically bind adenomatous polyposis coli mRNA, functioning regulate expression level. loss-of-function experiments, parabronchial smooth muscle cell significantly impaired, leading premature differentiation....
Abstract Evidence for striatal A2A‐D2 heterodimers has led to a new perspective on molecular mechanisms involved in schizophrenia and Parkinson's disease. Despite the increasing recognition of astrocytes’ participation neuropsychiatric disease vulnerability, involvement astrocytes A2A D2 receptor signal transmission never been explored. Here, we investigated presence receptors isolated astrocyte processes prepared from adult rat striatum by confocal imaging; effects activation were measured...
Perfluoro-alkyl substances (PFAS), particularly perfluoro-octanoic acid (PFOA), are persisting environmental chemicals showing bioaccumulation in human tissues. Recently, exposure to PFAS has been associated with increased prevalence of cardiovascular diseases (CVDs). However, a causal role atherosclerosis pathogenesis is under-investigated. Here, we investigated the effect PFOA on platelets' function, key player process. accumulation platelets was evaluated by liquid chromatography-mass...
Abstract Perfluoroalkyl substances (PFAS) are a class of compounds used in industry and consumer products. Perfluorooctanoic acid (PFOA) is the predominant form human samples has been shown to induce severe health consequences, such as neonatal mortality, neurotoxicity, immunotoxicity. Toxicological studies indicate that PFAS accumulate bone tissues cause altered development. Epidemiological have reported an inverse relationship between health, however associated mechanisms still unexplored....