A5004748763- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Neural dynamics and brain function
- Pain Management and Treatment
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuroendocrine Tumor Research Advances
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Musculoskeletal pain and rehabilitation
- Gallbladder and Bile Duct Disorders
- Botulinum Toxin and Related Neurological Disorders
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nerve Injury and Rehabilitation
Kumamoto University
2016-2025
Osaka University
2015-2025
Osaka University Hospital
2017-2024
Tokyo Metropolitan University
2024
Osaka Metropolitan University
2023-2024
Kashiwa Municipal Hospital
2020-2022
Matsushita Memorial Hospital
2006-2021
Osaka City General Hospital
2016-2019
Osaka Prefectural Medical Center
2016-2019
Otemae Hospital
2012-2014
Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that PINK1 is rapidly degraded in healthy mitochondria but accumulates on the membrane potential (ΔΨm)-deficient mitochondria, where it recruits another PD gene product, Parkin, to ubiquitylate damaged mitochondria. Despite extensive study, mechanism underlying homeostatic control remains unknown. Here we report autophosphorylated following decrease ΔΨm and most...
Abstract Core features of human cognition highlight the importance capacity to focus on information distinct from events in here and now, such as mind wandering. However, brain mechanisms that underpin these self-generated states remain unclear. An emerging hypothesis is depend process memory replay, which linked sharp-wave ripples (SWRs), are transient high-frequency oscillations originating hippocampus. Local field potentials were recorded hippocampus 10 patients with epilepsy for up 15...
Object The authors previously reported that navigation-guided repetitive transcranial magnetic stimulation (rTMS) of the precentral gyrus relieves deafferentation pain. Stimulation parameters were 10 trains 10-second 5-Hz TMS pulses at 50-second intervals. In present study, they used various frequencies and compared efficacies between two types lesions. Methods Patients divided into groups: those with a cerebral lesion noncerebral lesion. rTMS was applied to all patients 1, 5, Hz as sham...
Central post-stroke pain (CPSP) is one of the most common types intractable pain. We reported that repetitive transcranial magnetic stimulation (rTMS) primary motor cortex relieves for patients who were refractory to medical treatment. But mechanism unclear. In present study, we investigated relations between characteristics CPSP and results fiber tracking, which only noninvasive method evaluating anatomical connectivity white matter pathways. Fiber tracking corticospinal tract (CST)...
Low-frequency, bilateral stimulation of the subthalamic nucleus can improve axial symptoms advanced Parkinson's disease (PD), but it is not particularly effective for segmental symptoms.The optimal contacts low-frequency (60 Hz) and high-frequency (130 single monopolar were determined. Then, in a randomized, double-blind, prospective crossover manner, 60-Hz 130-Hz stimulations via respective compared immediate efficacy improving motor function patients with PD.The situated more ventrally...
Central poststroke pain (CPSP) is one of the most refractory chronic syndromes. Repetitive transcranial magnetic stimulation (rTMS) primary motor cortex has been demonstrated to provide moderate relief for CPSP. However, mechanism underlying remains unclear. The objective this study was assess changes in cortical excitability patients with intractable CPSP before and after rTMS cortex. Subjects were 21 hand who underwent rTMS. resting threshold, amplitude evoked potential, duration silent...
Meiotic recombination is critical for genetic exchange and generation of chiasmata that ensures faithful chromosome segregation during meiosis I. initiated by DNA double-strand break (DSB) followed multiple processes repair. The exact mechanisms how recombinases localize to DSB remain elusive. Here, we show C19orf57/4930432K21Rik/BRME1 a player meiotic in mice. associates with single-stranded (ssDNA) binding proteins, BRCA2 MEILB2/HSF2BP, which are recruiters onto sites. Disruption shows...
The death receptor 5 (DR5) is a for tumor necrosis factor‐related apoptosis‐inducing ligand and able to induce apoptosis in various cells. expression of DR5 up‐regulated at the transcriptional level by p53, genotoxic stress so on. To investigate structure gene promoter, we screened sequenced genomic clone containing 5′‐flanking region gene. RNase protection assays showed two major transcription start sites around −122 −137 upstream translation initiation codon ATG. Transient transfections...
Event-related cerebral oscillatory changes reflect regional brain activation. In a previous study, the authors proposed new method to determine language dominance: examine frontal during silent reading by using synthetic aperture magnetometry (SAM). The authors' aims in present study were establish normal template for this method, confirm results of their with larger patient population, and evaluate respect localization.A statistical group analysis 14 healthy volunteers was conducted...
During meiotic prophase, sister chromatids are organized into axial element (AE), which underlies the structural framework for events such as recombination and homolog synapsis. HORMA domain-containing proteins (HORMADs) localize along AE play critical roles in regulation of those events. Organization is attributed to two groups proteins: cohesins REC8 RAD21L; components SYCP2 SYCP3. It has been elusive how these chromosome contribute chromatin loading HORMADs prior formation. Here we newly...
We aimed to develop the deep learning (DL) predictive model for postoperative early recurrence (within 2 years) of hepatocellular carcinoma (HCC) based on contrast-enhanced computed tomography (CECT) imaging. This study included 543 patients who underwent initial hepatectomy HCC and were randomly classified into training, validation, test datasets at a ratio 8:1:1. Several clinical variables arterial CECT images used create models recurrence. Artificial intelligence implemented using...
Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface cells, this subsequently induces cytoskeletal rearrangement through Rac1 activation. However, intracellular signalling cascades that result in activation remain largely unknown. Here we show G-protein-coupled receptor kinase 6 (GRK6) involved cell clearance. GRK6 cooperates with GIT1 to activate Rac1, which promotes independently from...
Abstract During spermatogenesis, meiosis is accompanied by a robust alteration in gene expression and chromatin status. However, it remains elusive how the meiotic transcriptional program established to ensure completion of prophase. Here, we identify protein complex that consists germ-cell-specific zinc-finger ZFP541 its interactor KCTD19 as key regulators mouse prophase progression. Our genetic study shows are co-expressed from pachytene onward play an essential role testis. Furthermore,...
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder characterized by gait disturbance, cognitive impairment, and incontinence. It unclear whether the pathophysiology of iNPH associated with alterations in default mode network (DMN). The authors investigated DMN patients sought to determine relationship exists between resting-state functional connectivity patient's clinical symptoms.Resting-state MRI (rs-fMRI) was performed 16 preoperative 15 neurologically healthy...
eIF5-mimic protein (5MP) is a translational regulatory that binds the small ribosomal subunit and modulates its activity. 5MP proposed to reprogram non-AUG translation rates for oncogenes in cancer, but role controlling initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed fragile-X-associated tremor ataxia syndrome (FXTAS), unknown. Here, we show can suppress both general repeat-associated (RAN) by common mechanism manner dependent on interaction with eIF3....
Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic I, homologous chromosomes undergo synapsis to facilitate recombination yielding crossovers. It remains largely elusive how homolog temporally maintained and destabilized during I. Here we show FBXO47 stabilizer synaptonemal complex male Disruption shows severe impact on synapsis, recombination, XY body formation, leading infertility. Notably, in absence...
Parasitoid wasps, one of the most diverse and species-rich animal groups on Earth, produce venoms that manipulate host development physiology to exploit resources. However, mechanisms actions these remain poorly understood. Here, we discovered endoparasitoid wasp, Asobara japonica , induces apoptosis, autophagy, mitotic arrest in adult tissue precursors its Drosophila larvae. We termed this phenomenon imaginal disc degradation (IDD). A multi-omics approach facilitated identification two...