A5063498025- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Simulation-Based Education in Healthcare
- Trauma and Emergency Care Studies
- Intraperitoneal and Appendiceal Malignancies
- Cardiac Arrest and Resuscitation
- Abdominal Surgery and Complications
- Immune Cell Function and Interaction
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal disorders and treatments
- Phagocytosis and Immune Regulation
- Emergency and Acute Care Studies
- Colorectal Cancer Surgical Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Ultrasound and Hyperthermia Applications
- Immune cells in cancer
- Palliative Care and End-of-Life Issues
- Disaster Response and Management
- Neonatal Health and Biochemistry
- COVID-19 and healthcare impacts
Lithuanian University of Health Sciences
2016-2025
Penn State Milton S. Hershey Medical Center
2023
Indiana University
2023
Thomas Jefferson University Hospital
2017
Vilnius University
2017
Georgetown University
2017
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
2006-2016
Kauno kolegija Higher Education Institution
2012
Kaunas University of Technology
2007-2010
Digestive Health Research Institute
2009
Abstract Heme oxygenase-1 (HO-1) is believed to represent a key enzyme for the protection of cells against “stress.” Its overexpression in different types human cancers supports notion that HO-1 provides growth advantage and contributes cellular resistance chemotherapy radiotherapy. Given poor survival rates patients with pancreatic cancer due its aggressive behavior exceptional all known forms anticancer treatment, we have investigated expression prognosis. Expression was analyzed samples...
AIM:To study secretion patterns of pro-and anti-inflammatory cytokines, and activation various cellular subsets leukocytes in peripheral blood. METHODS:We have conducted a prospective observational study.One hundred eight patients with diagnosis acute pancreatitis onset the disease within last 72 h were included this study.The mRNA expression 25 different types cytokines white blood cells was determined by quantitative real time polymerase chain reaction.Levels 8 serum measured enzyme linked...
Thyroid surgeries are among the most common operations performed in world. Hypocalcemia following total thyroidectomy is a complication that sometimes difficult to correct. The aim of this study determine risk factors for hypocalcemia and their clinical value.From January 2015 through April 2017, 400 patients were included prospective multicenter study. All underwent due various thyroid diseases. analyzed: pre-operative post-operative biochemical blood parameters, effects related surgery,...
Aim To evaluate associations between rescuers' anthropometric characteristics and chest compressions (CC) depth according to 2010 resuscitation guidelines. Methods 186 medical pharmacy students, never trained in basic life support (BLS) before, underwent video self-instruction training. The participants were asked perform a BLS test on manikin connected PC for 6 min immediately after training, the quality of cardiopulmonary (CPR) skills was evaluated. Results Women with body weights less...
Recent data shows that patients with severe acute pancreatic might benefit from early intensive therapy, enteral nutrition and timely transfer to specialized centers. The prophylactic use of antibiotics in AP remains controversial. role need for new markers stratification pancreatitis is also uncertain. This study aims evaluate the prognostic usefulness adipokines prediction severity outcome (AP). Prospective was conducted four clinical diagnosis assessment established according revised 2012...
AIM:To assess the value of widely used clinical scores in early identification acute pancreatitis (AP) patients who are likely to suffer from intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). METHODS:Patients (n = 44) with AP recruited this study were divided into two groups (ACS non-ACS) according pressure (IAP) determined by indirect measurement using transvesical route via Foley bladder catheter.On admission at regular intervals, severity presence organ...
Objective. Several tools have been developed for severity stratification in acute pancreatitis (AP). They include single biochemical markers and complex scoring systems, all of which aim at an early detection severe AP to optimize monitoring treatment these patients. The this study was reassess compare the value some known newly-introduced prognostic clinical context. Material Methods. We conducted a prospective observational study. One hundred eight patients with diagnosis onset disease...
Background. Acute pancreatitis is a potentially serious condition. It carries an overall mortality rate of 10–15%. Infectious complications account for approximately 80% deaths from acute pancreatitis, and the question arises whether or not prophylactic antibiotics are useful in prevention these complications. Therefore, we performed evidence-based analysis to assess effect available antimicrobial treatment on development infected necrosis sepsis, need surgery, mortality. Methods. A...
The aim of the study was to evaluate and compare microcirculatory perfusion during experimental sepsis in different potentially available parts body, such as sublingual mucosa, conjunctiva eye, mucosa jejunum rectum.Pigs were randomly assigned (n = 9) sham 4) groups. group received a fixed dose live Escherichia coli infusion over 1-hour period (1.8 × 10(9)/kg colony-forming units). Animals observed 5 hours after start E. infusion. In addition systemic hemodynamic assessment, we performed...
Treatment of advanced colorectal cancer (CRC) depends on the correct selection personalized strategies. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a natural proteolipid milk compound that might serve as novel prevention and therapy candidate. Our purpose was investigate effect viability, death pathway mitochondrial bioenergetics CRC cells with different KRAS/BRAF mutational status in vitro.We treated three cell lines (Caco-2, LoVo, WiDr) evaluate metabolic activity flow...
To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, cisplatin concentration in different digestive system cancer cells.AGS (gastric cell line), Caco-2 (colon line) T3M4 (pancreatic were treated by temperature setting (37 °C 45 °C) either isolation, or combination. Treatment lasted for one hour. 48 h after treatment viability was evaluated MTT, apoptosis Annexin V-PE 7ADD flow cytometry. Intracellular measured immediately treatment, using mass...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms cancer, and despite low incidence rates, it remains sixth leading cause cancer related deaths worldwide. Immunotherapy, which aims to enhance immune system's ability recognize eliminate cells, has emerged as a promising approach in battle against PDAC. PARP7, mono-ADP-ribosyltransferase, negative regulator type I interferon (IFN-I) pathway been reported reduce anti-tumour immunity. We used murine pancreatic CR705,...
Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind to the immunoreceptor NKG2D play an important role in mediating cytotoxicity of NK T cells. Release MIC molecules from cell surface is thought constitute immune escape mechanism tumor cells thus could be associated with more aggressive course growth. In this study, we investigated expression MICA/B ductal pancreatic carcinoma serum relation stage, differentiation survival....
AIMTo explore the outcomes and appropriate treatment for patients with moderately severe acute pancreatitis (AP). METHODSStatistical analysis was performed on data from prospectively collected database of 103 AP admitted to Department Surgery, Hospital Lithuanian University Health Sciences in 2008-2013.All were confirmed have diagnosis during first 24 h following admission.The severity assessed by MODS APACHE Ⅱ scale.Clinical course re-evaluated after 24, 48 72 h.All categorized into 3...
The aim of this study was to evaluate the utility magnetic resonance imaging (MRI) for noninvasive assessment pancreatic fibrosis (PF).Fifty-two patients who underwent surgical resection pancreas, histological examination margins, preoperative abdominal MRI, and fecal elastase-1 test were enrolled in study. Pancreatic tissue identified on MRI T1-, T2-, diffusion-weighted sequences. Apparent diffusion coefficient (ADC) measured at expected margin pancreas.There a significant negative...
Background and Objectives: Both chronic pancreatitis (CP) pancreatic ductal adenocarcinoma (PDAC) may lead to cachexia, sarcopenia, osteoporosis due different mechanisms. Neither patient gender, age, nor body weight are good predictors of these metabolic changes having a significant negative impact on the quality life (QOL) treatment outcomes. The aim this study was evaluate radiological in composition compare them with manifestations exocrine endocrine insufficiency, mass, QOL among...
Gata-3 has been shown to specifically alter its expression patterns in different types of cancers. Recent evidence suggests that an interference exists the TGF-beta signaling pathway. To determine role pancreatic cancer, cancer samples were analyzed comparison normal tissues. Furthermore, four cell lines with alterations pathway studied. evaluate if a potential relationship exists, we correlated mRNA levels TGF-betas, receptors, and Smad-3. Finally, influence on vitro. All demonstrated...
Background and objective. Management of the abdominal compartment syndrome during severe acute pancreatitis by open abdomen method is associated with considerable morbidity resource utilization. Thus, aim this study was to evaluate safety efficacy ultrasound-guided percutaneous interventions and/or minimally invasive surgery in treatment syndrome. Material methods. Forty-four patients were enrolled into a prospective treated according standard management protocol. Interventional and/ or...
A steady decline in gastric cancer mortality rate over the last few decades is observed Western Europe. However it still not clear if this trend applies to Eastern Europe where high incidence of observed.This was a retrospective non-randomized, single center, cohort study. During study period 557 consecutive patients diagnosed with which curative operation performed met inclusion criteria. The population divided into two groups according equal time periods: 01-01-1994 - 31-12-2000 (Group I...
A precise tool for analysis of trauma team performance is missing.To create a framework and feedback.An observational study in level I centre Lithuania was performed from January 1 2017 to August 31 2017. Audio/video review process used evaluate technical nontechnical the team.In total, 143 activations were analysed. The mean rate completion primary survey based on Advanced Trauma Life Support principles 68.5%. Technical steps patient resuscitation measured seconds during first hour...
Objective. Fine-needle aspiration (FNA) is the procedure of choice for accurate diagnosis infected necrosis. However, invasive procedures increase risk secondary pancreatic infection and timing FNA still a matter debate. Our objective was to assess value routine clinical tests determine minimal necrosis, thereby optimizing selection patients image-guided FNA. Material methods. This prospective, non-randomized study comprised 90 with acute necrotizing pancreatitis. The data 52 were used...