A5089824396- Multiple Sclerosis Research Studies
- Sphingolipid Metabolism and Signaling
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Rheumatoid Arthritis Research and Therapies
- Neurological and metabolic disorders
- Hepatitis B Virus Studies
- Peroxisome Proliferator-Activated Receptors
- Functional Brain Connectivity Studies
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Fractal and DNA sequence analysis
- Brucella: diagnosis, epidemiology, treatment
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Viral Infections and Outbreaks Research
- Mycobacterium research and diagnosis
- Family Support in Illness
- T-cell and Retrovirus Studies
- Genetic Syndromes and Imprinting
- Lymphadenopathy Diagnosis and Analysis
- Alcoholism and Thiamine Deficiency
- Peripheral Neuropathies and Disorders
- Heterotopic Ossification and Related Conditions
Hospital Santo António dos Capuchos
2012-2025
Universidade Nova de Lisboa
2025
Centro Hospitalar de Lisboa Central
2013-2024
Hospital de Santo António
2017-2022
Merck (Singapore)
2018
Novartis (Switzerland)
2018
Sanofi (France)
2018
Bayer (United States)
2018
Nova Medical (United States)
2018
Escola Superior de Saúde Egas Moniz
2012
Multiple sclerosis (MS) is a chronic autoimmune-mediated neurodegenerative disease characterized by inflammation, demyelination, and axonal/neuronal damage in the central nervous system. In Portugal, prevalence of MS approximately 64.4 per 100 000 individuals. It typically diagnosed young adults aged 30 to 40, with higher incidence women, although it can also affect children/adolescents elderly. Recent advances treatment include development approval several new disease-modifying therapies...
Objectives Cladribine is a selective and oral immunological reconstitution treatment, approved in Europe for very active multiple sclerosis (MS) with relapses. Aims were to assess the safety effectiveness of cladribine real-world setting, during treatment follow-up. Methods This was multicentric, longitudinal, observational study retrospective prospective data collection clinical, laboratory, imaging data. interim analysis reports from July 1, 2018 (study onset), March 31, 2021. Results A...
Ocrelizumab demonstrated significant clinical benefit for the treatment of relapsing (RMS) and primary progressive (PPMS) multiple sclerosis (MS), an incurable disease characterized by disability progression. This study evaluated economic impact ocrelizumab relative to current practice, including other disease-modifying therapies (DMT), available in Portugal.Markov models MS were adapted estimate across three patient populations: treatment-naïve RMS, previously treated PPMS. Health states...
Growing evidence suggests the involvement of adipose tissue in modulating clinical course relapsing–remitting multiple sclerosis (RRMS). This study aimed to investigate whether intake combined oral contraceptives (COCs) affects body weight and leptin adiponectin (APN) blood levels these patients. Clinical data from 62 women (M = 33.23 year) were recorded prior initiation disease-modifying therapy. Patients who taking COCs at time experiencing first symptoms disease (COC user) compared with...
The syndrome of bilateral basal ganglia lesions in diabetic uremic patients is a rare disorder mostly reported Asians. There are few reports the Caucasians. It manifests as an acute hyperkinetic or hypokinetic extrapyramidal association with uniform neuroimaging findings symmetrical changes diabetics undergoing hemodialysis. Its pathophysiology remains largely unknown. Thus, we report typical case Caucasian patient who developed and reversible akinetic rigid parkinsonism secondary to lesions.
Background: The mechanisms underlying the influence of sex hormones in multiple sclerosis (MS) are uncertain. Sex steroids interact with cholesterol metabolism and serum lipid profile has been associated severity disease. We hypothesized that putative associations between lipoprotein MS could be modulated by exposure. aim this study was to investigate whether oral contraceptives (OC) use changes disability patients sclerosis. Methods: Clinical data collected from 133 relapsing-remitting...
Introduction: Multiple sclerosis is a disease with heterogeneous evolution. The early identification of secondary progressive multiple clinical challenge, which would benefit from the definition biomarkers and diagnostic tools applicable in transition phase relapsing-remitting to sclerosis. We aimed reach Portuguese national consensus on monitoring patients more relevant variables for its progression.Material Methods: A Delphi panel included eleven Neurologists participated two rounds...
Fingolimod is an oral immunomodulatory drug used in the treatment of multiple sclerosis (MS) that may change lipid metabolism. Peroxisome proliferator-activated receptors (PPAR) are transcription factors regulate lipoprotein metabolism and immune functions have been implicated pathophysiology MS. CD36 a scavenger receptor whose PPAR regulated. The objective this study was to evaluate whether fingolimod modifies gene expression as part its action mechanisms. Serum profiles levels peripheral...
The aim of this study was to evaluate postmarketing fingolimod safety and effectiveness in a real-world clinical population.This retrospective, single-center with active multiple sclerosis patients treated at least 12 months follow-up. Demographic imaging characteristics, including annualized relapse rate (ARR), Expanded Disability Status Score, previous treatment, adverse events, treatment duration, reason for discontinuation, were analyzed.Sixty-three included; 61.9% females. Mean age mean...
Objectives The aim of this study was to evaluate postmarketing dimethyl fumarate (DMF) safety and effectiveness in a real-world population with relapsing-remitting multiple sclerosis (RRMS). Methods This retrospective, single-center RRMS patients treated DMF. Demographic, clinical, imagiological characteristics were analyzed, including annualized relapse rate (ARR), Expanded Disability Status Scale, “No Evidence Disease Activity 3,” previous treatment, adverse events, treatment duration,...
Epilepsy is one of the most important chronic neurological disorders worldwide affecting more than 50 million people all ages. Among these, almost 20% epilepsy cases are uncontrollable and have an unknown source this abnormal electrical activity. Present techniques for detection epileptogenic foci include electroencephalography (EEG), positron emission tomography, multimodal EEG/functional magnetic resonance imaging (fMRI), with limitations in terms spatial temporal resolutions. In order to...
The purpose of this study was to develop a new approach for the identification epileptogenic focus using Blood Oxygen Level Dependent (BOLD) signals from functional magnetic resonance imaging (fMRI) data. This novel is based on following hypotheses (1) BOLD signal during interictal state shows transient peaks activation, which differentiate it remaining brain; (2) less complex than those brain. A bi-dimensional temporal clustering analysis, data-driven technique, used identify brain regions...
Cross-sectional and necropsy studies have shown cancer to be less prevalent in Alzheimer's disease (AD) patients. Proposed mechanisms involve different propensity methylate DNA. On the other hand, previous reports demonstrated smoking, a known risk factor for cancer, protects against AD. Therefore, we sought answer if prevalence of AD patients could explained by lower smokers this population. We collected following data all our outpatient clinic: age, sex, smoking status (currently, former,...