A5008503977- Cardiac electrophysiology and arrhythmias
- Research on Leishmaniasis Studies
- Ion channel regulation and function
- T-cell and B-cell Immunology
- Trypanosoma species research and implications
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Immunotherapy and Immune Responses
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Ion Channels and Receptors
- Heart Failure Treatment and Management
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Pharmacology and Obesity Treatment
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Diet, Metabolism, and Disease
- Vector-borne infectious diseases
- Respiratory Support and Mechanisms
- Muscle Physiology and Disorders
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2004-2025
Agropolis International
2020-2025
Université de Montpellier
2010-2023
Institut de Recherche pour le Développement
2015-2023
Centre National de la Recherche Scientifique
2015-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
University of Oxford
2023
Université de Bordeaux
2021
Background The recent geographical expansion of phlebotomine vectors Leishmania infantum in the Mediterranean subregion has been attributed to ongoing climate changes. At these latitudes, activity sand flies is typically seasonal; because seasonal phenomena are also sensitive general variations climate, current phenological data sets can provide a baseline for continuing investigations on fly population dynamics that may impact future scenarios leishmaniasis transmission. With this aim,...
Patients with Duchenne muscular dystrophy (DMD) have a progressive dilated cardiomyopathy associated fatal cardiac arrhythmias. Electrical and functional abnormalities been attributed to fibrosis; however, electrical may occur in the absence of overt histopathology. Here we show that structural remodeling sarcoplasmic reticulum (SR) Ca 2+ release channel/ryanodine receptor (RyR2) occurs mdx mouse model DMD. RyR2 from hearts were S-nitrosylated depleted calstabin2 (FKBP12.6), resulting...
Myocardial ischemic disease is the major cause of death worldwide. After myocardial infarction, reperfusion infracted heart has been an important objective strategies to improve outcomes. However, cardiac ischemia/reperfusion (I/R) characterized by inflammation, arrhythmias, cardiomyocyte damage, and, at cellular level, disturbance in Ca 2+ and redox homeostasis. In this study, we sought determine how acute inflammatory response contributes injury homeostasis after ischemia. Using a rat...
Pulmonary hypertension provokes right heart failure and arrhythmias. Better understanding of the mechanisms underlying these arrhythmias is needed to facilitate new therapeutic approaches for hypertensive, failing ventricle (RV). The aim our study was identify generating in a model RV induced by pulmonary hypertension. Rats were injected with monocrotaline induce either hypertrophy or saline (control). ECGs measured conscious, unrestrained animals telemetry. In isolated hearts, electrical...
Rationale TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly atria or conduction tissue. Mutations Trpm4 gene were recently associated with several human disorders such as Brugada syndrome. has also been implicated at ventricular level, inotropism arrhythmia genesis due to stresses ß-adrenergic stimulation, ischemia-reperfusion, and hypoxia re-oxygenation. However, physiological role of healthy heart remains unclear. Objectives We aimed investigate on...
Sexual reproduction and meiotic sex are deeply rooted in the eukaryotic tree of life, but mechanisms determining or mating types extremely varied only well characterized a few model organisms
Thymus-derived regulatory T cells (Tregs) expressing CD4, CD25, and the transcription factor Foxp3 play major roles in preventing autoimmunity. The Treg population is enriched high-avidity self-reactive cell receptors, thymic epithelial self-antigens (Ag) have been implicated their induction and/or selection. However, selection events leading to lineage commitment remain unclear. We followed development of self-Ag-specific Tregs double-transgenic mice coexpressing a neo-self-Ag,...
Background Controlled mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction, which impedes weaning from ventilation. To design future clinical trials in humans, a better understanding of the molecular mechanisms using knockout models, exist only mouse, needed. The aims this study were to ascertain feasibility developing murine model dysfunction and determine whether atrophy, sarcolemmal injury, main proteolysis systems are activated under these conditions....
Leishmania (L.) infantum is the causative agent in an endemic focus of canine leishmaniasis Mont-Rolland district (Thiès, Senegal). In this area, transmission cycle well established and more than 30% dogs 20% humans are seropositive for L. infantum. However, sand fly species involved still unknown. Between 2007 2010, 3654 flies were collected from different environments (indoor, peridomestic, farming sylvatic areas) to identify main vector(s). Nine identified. The Phlebotomus genus (n = 54...
Phlebotomine sandflies are hematophagous insects widely present in Western Mediterranean countries and known for their role as Leishmania vectors. During the last ten years, risk of leishmaniasis re-emergence has increased France. However, sandfly biology ecology South France remain poorly because detailed study on spatiotemporal dynamics was performed over 30 years ago. The aim to update our knowledge by determining investigating relationship between environmental/climatic factors presence...
Abstract Pertussis toxin (PTx) is a bacterial used to enhance the severity of experimental autoimmune diseases such as encephalomyelitis. It known promote permeabilization blood-brain barrier, maturation APC, activation autoreactive lymphocytes and alteration lymphocyte migration. In this study, we show that i.v. injection PTx in mice induces decrease number splenic CD4+CD25+ regulatory T cells (Treg cells). Furthermore, not only depletion dominant CD4+CD25+Foxp3+ subpopulation Treg cells,...
Phlebotomus ariasi Tonnoir, 1921, is the predominant sand fly species in Cevennes region and a proven vector of Leishmania infantum, which main pathogen visceral canine leishmaniasis south France. Even if this widely present Western Mediterranean countries, its biology ecology remain poorly known. The goals work are to investigate phenotypic variation P. at local scale characterized by climatic environmental fluctuations, determine slope altitude could affect phenotypes. Sand flies were...
Plasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. Nevertheless, our comprehension of this parasite’s biology remains limited, primarily due its frequent co-infections with other lack a continuous in vitro culture system. To effectively combat eliminate overlooked parasite, it imperative acquire better understanding species. In study, we embarked on an investigation P. , including exploring clinical disease...
Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity IR require further investigation. Therefore, we compared the metabolic of a combination grape supplementation in obese rats with high-fat diet (EXOPP) effect alone (HF) or nutritional (PP) endurance (EXO) during 8 wks. We observed an improvement systemic skeletal muscle sensitivity EXO EXOPP rats. HF presented lower insulinemia HOMA-IR higher liver...
During heart failure (HF), the left ventricle (LV) releases B-type natriuretic peptide (BNP), possibly contributing to adverse cardiovascular events including ventricular arrhythmias (VAs) and LV remodelling. We investigated cardiac effects of chronic BNP elevation in healthy mice compared results with a model HF after myocardial infarction (PMI mice). Healthy were exposed circulating levels (BNP-Sham) similar those measured PMI mice. Telemetric surface electrocardiograms showed that...
Abnormalities in cardiomyocyte Ca2+ handling contribute to impaired contractile function heart failure (HF). Experiments on single ryanodine receptors (RyRs) incorporated into lipid bilayers have indicated that RyRs from failing hearts are more active than those healthy hearts. Here, we analyzed spontaneous sparks (brief, localized increased [Ca2+]i) evaluate RyR cluster activity situ a mouse post-myocardial infarction (PMI) model of HF. The cardiac ejection fraction PMI mice was reduced...
SR33805, a potent Ca(2+) channel blocker, increases cardiac myofilament sensitivity in healthy rat cardiomyocytes. Therefore, the aim of present study was to evaluate effects SR33805 on contractile properties ischaemic failing hearts after myocardial infarction (MI) vivo and vitro at cellular level.The effect (10 µM) tested excitation-contraction coupling cardiomyocytes isolated from with end-stage heart failure. Cell shortening transients were measured intact cardiomyocytes, while...
Scope: We compared the effects of two dealcoholized wines, persimmon (P) and Merlot (M), in hypercholesterolemic hamsters. Methods results: Four groups hamsters received a standard (ST) or an atherogenic diet (AT) for 12 weeks. AT animals either wine (AT + P) M) by gavage, while controls water ST). Plasma cholesterol, triglycerides glucose paraoxonase activity were measured. Oxidative stress was assessed aortic O2°− production, vascular function evaluated rings. The led to higher plasma...
<h3>Aims</h3> Clinical studies failed to prove convincingly efficiency of intravenous infusion neseritide during heart failure and evidence suggested a pro-adrenergic action B-type natriuretic peptide (BNP). However, subcutaneous BNP therapy was recently proposed in failure, thus raising new perspectives over what considered as promising treatment. We tested the combination oral β1-adrenergic receptor blocker metoprolol decompensated failure. <h3>Methods results</h3> The effects or/and were...
Prevention of adverse cardiac remodeling after myocardial infarction (MI) remains a therapeutic challenge. Angiotensin-converting enzyme inhibitors (ACE-I) are well-established first-line treatment. ACE-I delay fibrosis, but little is known about their molecular effects on cardiomyocytes. We investigated the delapril cardiomyocytes in mouse model heart failure (HF) MI. Mice were randomly assigned to three groups: Sham, MI, and MI-D (6 weeks treatment with non-hypotensive dose started 24h...