A5054743025- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Neuroscience of respiration and sleep
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Parkinson's Disease and Spinal Disorders
- Cholinesterase and Neurodegenerative Diseases
- Redox biology and oxidative stress
- Cerebral Palsy and Movement Disorders
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Lipid Membrane Structure and Behavior
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
University of the Basque Country
2016-2025
BioCruces Health research Institute
2019-2023
Universidad de Cantabria
2005
Parkinson's disease (PD) is the most common motor neurodegenerative disorder, characterised by aggregated α-synuclein (α-syn) constituting Lewy bodies. We aimed to investigate temporal changes in impairments a PD mouse model induced overexpression of α-syn with conventional manual analysis balance beam test and novel approach using machine learning algorithms automate behavioural analysis. combined automated animal tracking markerless pose estimation DeepLabCut, classification Simple...
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, but current therapies are only symptomatic. A promising alternative to address process use of neurotrophic factors, such as glial cell-derived factor (GDNF). However, its clinical has been limited due short half-life and rapid degradation after in vivo administration, addition difficulties crossing blood-brain barrier (BBB). This a limiting brain drug development, making future progression neurotherapeutics...
Increased antiparkinson efficacy of the combined administration VEGF- and GDNF-loaded nanospheres in a partial lesion model Parkinson's disease Enara Herrán,1,2 Catalina Requejo,3 Jose Angel Ruiz-Ortega,4 Asier Aristieta,4 Manoli Igartua,1,2 Harkaitz Bengoetxea,3 Luisa Ugedo,4 Luis Pedraz,1,2 Vicente Lafuente,3 Rosa Maria Hernández1,2 1NanoBioCel Group, Laboratory Pharmaceutics, University Basque Country (UPV/EHU), School Pharmacy, Vitoria, Spain; 2Biomedical Research Networking Center...
The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with dysfunctional neuronal activity in several nuclei the basal ganglia. Moreover, high levels oscillatory synchronization have also been described both intra- inter-basal ganglia cerebral cortex. However, relevance these alterations motor symptomatology related to Parkinsonism LID not fully understood. Recently, we shown that subthalamic correlates axial abnormal movements a nucleus (STN)...
L-DOPA is the most effective treatment for Parkinson's disease (PD), but prolonged use leads to disabling motor complications including dyskinesia. Strong evidence supports a role of subthalamic nucleus (STN) in pathophysiology PD whereas its dyskinesia matter controversy. Here, we investigated involvement STN dyskinesia, using single-unit extracellular recording, behavioural and molecular approaches hemi-parkinsonian rats rendered dyskinetic by chronic administration. Our results show that...
There is substantial evidence supporting a role for the endocannabinoid system as modulator of dopaminergic activity in basal ganglia, forebrain that integrates cortical information to coordinate motor regulating signals. In fact, administration plant-derived, synthetic or endogenous cannabinoids produces several effects on function. These are mediated primarily through CB(1) receptors densely located dopamine-enriched ganglia networks, suggesting endocannabinoids due, at least part,...
<title>Abstract</title> Parkinson's disease (PD) is a prevalent neurodegenerative disorder affecting 1-5% of individuals over 60, with higher incidence in men. It characterized by progressive motor impairments, such as rigidity, bradykinesia, tremors, and gait disturbances. The neuropathological hallmark PD the aggregation α-synuclein (α-syn) into Lewy bodies (LB) neurites (LN). While α-syn plays essential physiological roles, its misfolding accumulation drive neurodegeneration.<bold>...
The physiopathology of levodopa-induced dyskinesias (LIDs) is unclear. Presynaptic pharmacokinetic and postsynaptic pharmacodynamic mechanisms may be involved. We have analyzed several clinical pharmacological parameters, as well the status presynaptic dopamine nigrostriatal pathway by using DaTSCAN, in 14 patients with Parkinson disease who developed early severe LID despite low doses levodopa 10 without this complication use high doses. Patients were matched for age at onset, duration,...
The most effective treatment for Parkinson's disease (PD), l-DOPA, induces dyskinesia after prolonged use. We have previously shown that in 6-hydroxydopamine (6-OHDA) lesioned rats rendered dyskinetic by l-DOPA administration, lesion of the subthalamic nucleus (STN) reduces not only dyskinesias but also buspirone antidyskinetic effect. This study examined effect on STN neuron activity. Cell-attached recordings parasagittal slices from naïve showed whilst serotonin excited majority neurons,...
Within the basal ganglia, subthalamic nucleus (STN) is only glutamatergic structure and occupies a central position in indirect pathway. In rat, STN receives serotonergic input from dorsal raphe expresses receptors. This study examined consequences of neurotransmission modulation on neuron activity. vivo single-unit extracellular recordings, HPLC determination, rotarod bar test were performed control, 4-chloro-DL-phenylalanine methyl ester hydrochloride- (pCPA, serotonin synthesis inhibitor)...
The search for experimental models mimicking an early stage of Parkinson´s disease (PD) before motor manifestations is fundamental in order to explore signs and get a better prognosis. Interestingly, our previous studies have indicated that 6-hydroxydopamine (6-OHDA) suitable model induce degeneration the nigrostriatal system without any gross impairment. Considering findings, we aim implement novel monitor rats after intrastriatal injection 6-OHDA detect analyze physiological changes...
To investigate whether agmatine (the proposed endogenous ligand for imidazoline receptors) controls locus coeruleus neuron activity and to elucidate its mechanism of action, we used single‐unit extracellular recording techniques in anaesthetized rats. Agmatine (10, 20 40 μg, i.c.v.) increased a dose‐related manner the firing rate neurons (maximal increase: 95±13% at μg). I 1 ‐imidazoline receptor ligands stimulate through an indirect originated paragigantocellularis nucleus via excitatory...
The population of reserve alpha-2 adrenoceptors that mediate the inhibitory effect clonidine on activity locus coeruleus neurons has been studied using extracellular recordings in anesthetized rats. Animals were pretreated with irreversible receptor antagonist N-ethoxycarbonyl-2-ethoxy-1-2-dihydroquinoline (EEDQ). In rats EEDQ (1, 2 and 6 mg/kg, i.p., hr before experiment), there was an increase firing rate, a reduction regularity (i.e., increased variation coefficient) burst neurons....