A5007292898- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Lysosomal Storage Disorders Research
- Healthcare and Venom Research
- Cellular transport and secretion
- Heme Oxygenase-1 and Carbon Monoxide
- Microscopic Colitis
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Entomological Studies and Ecology
- Helicobacter pylori-related gastroenterology studies
- Carbohydrate Chemistry and Synthesis
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Venomous Animal Envenomation and Studies
- Clinical Nutrition and Gastroenterology
- Autoimmune and Inflammatory Disorders Research
- Nuclear Receptors and Signaling
- Virus-based gene therapy research
- Animal Genetics and Reproduction
- Gastrointestinal motility and disorders
- Paraquat toxicity studies and treatments
- Asthma and respiratory diseases
Italian Institute of Technology
2020-2025
Instituto Butantan
2018-2023
Universidade de São Paulo
2012-2021
Universidade de Ribeirão Preto
2018-2021
Universidade Brasil
2014
Clinics Hospital of Ribeirão Preto
2012
Transcriptional control of transgene expression can be linked to dynamic changes in cellular states if this is accompanied by differential transcription factors (TFs). Synthetic promoters (SPs) designed respond the desired TFs provide regulation with compactness, specificity, and orthogonality. T cells display differentially expressed according functional state. In solid tumors, highly immunosuppressive TME chronic exposure antigens lead a progression from dysfunctional state known as...
CCR5, an important receptor related to cell recruitment and inflammation, is expressed during experimental Toxoplasma gondii infection. However, its role in the immunopathology of toxoplasmosis not clearly defined yet. Thus, we inoculated WT CCR5-/- mice with a sub lethal dose parasite by oral route. were extremely susceptible infection, presenting higher load lower tissue expression IL-12p40, IFN-γ, TNF, IL-6, iNOS, Foxp3, T-bet, GATA-3 PPARα. Although both groups presented inflammation...
Abstract Heme oxygenase-1 (HO-1) is an enzyme that catabolizes free heme, which induces intense inflammatory response. The expression of HO-1 induced by different stimuli, triggering anti-inflammatory response during biological stress. It was previously verified able to induce indoleamine 2,3-dioxygenase (IDO), IFN-γ in Toxoplasma gondii infection. To verify the role vivo T . infection, BALB/c and C57BL/6 mice were infected with ME49 strain treated zinc protoporphyrin IX (ZnPPIX) or hemin,...
The current therapeutic options for Inflammatory Bowel Diseases (IBD) are limited. Even using common anti-inflammatory, immunosuppressive or biological therapies, many patients become unresponsive to the treatments, immunosuppressed unable restrain secondary infections. Statins cholesterol-lowering drugs with non-canonical anti-inflammatory properties, whose underlying mechanisms of action still remain poorly understood. Here, we described that
Sepsis is a severe syndrome that arises when the host response to an insult exacerbated, leading organ failure and frequently death. How chronic infection causes prolonged Th1 expansion affects course of sepsis unknown. In this study, we showed mice chronically infected with Toxoplasma gondii were more susceptible induced by cecal ligation puncture (CLP). Although T. gondii-infected exhibited efficient control bacterial burden, they increased mortality compared groups. Mechanistically,...
Most anti-inflammatory drugs currently adopted to treat chronic inflammatory joint diseases can alleviate symptoms but they do not lead remission. Therefore, new and more efficient are needed block the course of diseases. Animal venoms, rich in bioactive compounds, contribute as valuable tools this field research. In study, we first demonstrate direct action venoms on cells that constitute articular joints. We established a platform consisting cell-based assays evaluate release cytokines...
<title>Abstract</title> Gaucher Disease (GD) is an autosomal recessive, lysosomal storage disease caused by pathogenic variants in the glucocerebrosidase gene, leading to loss of b-glucocerebrosidase (GCase) enzymatic activity. Enzyme replacement therapy (ERT) with recombinant GCase standard care GD patients. Our study investigates combined use <italic>in silico</italic> molecular evolution, synthetic biology and gene approaches develop a new enzyme. We engineered four GCases containing...
Abstract The Toxoplasma gondii infection induces intense intestinal inflammation and tissue damage in susceptible hosts. Here, we studied the regulation of immune response during mucosal induced by T. gondii, focusing on role Th17, Th22 regulatory T cells (Tregs). C57BL/6-susceptible BALB/c-resistant mice orally infected with exhibited increased frequencies Th17 Lamina Propria Peyers patches disease progression. However, whereas C57BL/6 higher frequency BALB/c showed counts Treg cells. also...
Abstract Introduction: Autoimmune diseases including type 1 diabetes (T1D) are thought to have a Th1/Th17 bias, but the underlying mechanisms driving differentiation and activation of these pathogenic T cells has been investigated. Recently, IL-1beta shown regulate Th17 cell through expression transcription factor RORγt. Objective: For this reason, we addressed respective IL-1 receptor (IL-1R) role in TD1. Methods: IL-1R deficient mice their wild-type (C57BL/6) were inoculated...
Abstract Introduction: The majority of studies regarding host-pathogen interactions have focused on a single pathogen. However, host organisms in natural environment are commonly exposed to multiple pathogens, such as T. gondii infection, which induces strong immune response by Th1 pathway, that can persists throughout the life host. Therefore, we hypothesized chronic infection with could alter course against bacterial infection. Methodology: C57BL/6 mice were orally infected 5 cysts ME-49...