A5029656711- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects and Toxicity Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Pharmacology and Obesity Treatment
- Drug Transport and Resistance Mechanisms
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Stress Responses and Cortisol
- Neurobiology and Insect Physiology Research
- Antimicrobial Peptides and Activities
- Cannabis and Cannabinoid Research
- Pain Management and Opioid Use
- Memory and Neural Mechanisms
- Bipolar Disorder and Treatment
- Animal testing and alternatives
- Bacillus and Francisella bacterial research
- Spinal Cord Injury Research
Instituto Butantan
2006-2021
Universidade Metodista de São Paulo
2012-2014
Universidade Federal de São Paulo
2005
Associação Paulista de Medicina
1992-1998
Istituto di Farmacologia Traslazionale
1998
Bradykinin (BK) and its related peptides are widely distributed in venomous animals, including wasps. In fact, we have previously purified a novel BK-related peptide (BRP) named Cd-146 the threonine(6)-bradykinin (Thr(6)-BK) from venom of solitary wasp Cyphononyx fulvognathus. Further survey this same extract allowed structural characterization two other BRPs, here as fulvonin cyphokinin. Biochemical performed showed that although high primary structure similarity observed with BK, these not...
1. The effects of the main component Tityus serrulatus scorpion venom, toxin TsTX-I, were studied on contractility and release neurotransmitters in rat vas deferens. Since TsTX-I is known to act sodium channels, we used veratridine, another channel agent, for comparison. 2. Toxin induced concentration-dependent contractions with an EC(50) value 47.8+/-0.1 nM a maximum effect 84.4+/-10.4% that BaCl(2). 3. Contractions by abolished denervation or tetrodotoxin (0.1 microM), showing depend...
In adult female mammals, reproductive experience (e.g., mating, pregnancy, parturition, and lactation) has long-term behavioral, endocrine, neurochemical implications.This causes behavioral changes that involve several brain areas important for the expression of maternal behavior.The present study showed lactating rats exhibited reduced general locomotor activity in open field test compared with virgin animals.Our hypothesis was nucleus accumbens dopamine, which regulates behavior rats, is...
TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about pharmacological action in central nervous system. The objective this work was determine electroencephalographic, behavioral and histopathological effects intrahippocampal injection TsTX-I. Rats were anesthetized fitted with cannulae for into hippocampus electrodes cerebral recording. animals treated Ringer solution, some doses...
Toxin-γ (Tγ) from the Brazilian scorpion Tityus serrulatus venom caused a concentration- and time-dependent increase in release of norepinephrine epinephrine bovine adrenal medullary chromaffin cells. Tγ was ∼200-fold more potent than veratridine judged EC 50 values, although maximal secretory efficacy 10-fold greater that (1.2 vs. 12 μg/ml catecholamine release). The combination both toxins produced synergistic effect particularly drastic at 5 mM extracellular Ca 2+ concentration ([Ca ] o...
Chronic antidepressant administration increases neurotrophin levels in the central and peripheral nervous system, leading to an increase of neuronal sprouting, reestablishment neural networks neurotransmitter levels. Injured nerves regenerate at very slow rates. However, recovery hypogastric nerve rodents after injury is significantly improved with administration. Accordingly, our goal was determine whether treatment fluoxetine affects catecholamine function, surgical denervation rat vas...