A5014260445- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Long-Term Effects of COVID-19
- Genetic Neurodegenerative Diseases
- Pharmacological Effects and Toxicity Studies
- Glycogen Storage Diseases and Myoclonus
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Neurological and metabolic disorders
- Motor Control and Adaptation
- Autoimmune Neurological Disorders and Treatments
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Attention Deficit Hyperactivity Disorder
- Chronic Disease Management Strategies
- Pain Mechanisms and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Cancer Treatment and Pharmacology
- Neuroscience and Neuropharmacology Research
- Ophthalmology and Eye Disorders
Università Cattolica del Sacro Cuore
2018-2025
Sapienza University of Rome
2020-2024
Agostino Gemelli University Polyclinic
2018-2024
John Wiley & Sons (United States)
2022
To evaluate the effects of cerebellar transcranial alternating current stimulation (tACS) delivered at cerebellar-resonant frequencies, i.e., theta (θ) and gamma (γ), on upper limb motor performance cerebellum-primary cortex (M1) connectivity, as assessed by cerebellar-brain inhibition (CBI), in healthy subjects. Participants underwent cerebellar-tACS while performing three cerebellar-dependent tasks: (i) rhythmic finger-tapping, (ii) arm reaching-to-grasp ('grasping') (iii)...
Abstract Background and purpose Essential tremor (ET) is a common heterogeneous disorder characterized by postural/kinetic of the upper limbs other body segments non‐motor symptoms, including cognitive psychiatric abnormalities. Only limited number longitudinal studies have comprehensively simultaneously investigated motor symptom progression in ET. Possible soft signs that configure ET‐plus diagnosis are also under‐investigated follow‐up studies. We aimed to longitudinally investigate ET...
Tremor is a common movement disorder that can be induced by medications, including valproate, which used for the treatment of epilepsy. However, clinical and neurophysiological features valproate-induced tremor are still under-investigated. We performed kinematic assessment considering body distribution activation conditions. investigated possible correlations between demographic data features. Valproate-induced results were also compared with those collected in large sample patients...
Background Advances in STN-DBS technology, among which directional stimulation, improved Parkinson's disease (PD) treatment efficacy, while increasing the clinical programming complexity. Lead localization software may aid stimulation contact selection process. Objective We aimed to assess concordance between imaging-suggested (IGP) and conventional-programming (CP) selected contacts one year after surgery its impact on motor outcomes. Methods Sixty-four PD patients with bilateral were...
To date, only a few clinical and neurophysiological studies have assessed the features of valproate-induced tremor (VIT), whether valproate (VPA) affects voluntary movements is underinvestigated.To better characterize VIT in patients with epilepsy effect VPA on execution movement.We tested 29 (13 taking alone 16 plus other antiepileptics). Patients underwent neurological examination, video recordings kinematic assessments postural, kinetic, resting upper limb using motion analysis system....
Among the several components constituting a pulmonary rehabilitation (PR) course, education may contribute to an individual's recognition of symptoms and worsening disease. However, specific benefits is far greater than can be clearly documented health care providers. The aim our preliminary study was assess learning impact educational sessions (ES) in Chronic Obstructive Pulmonary Disease (COPD) patients referred standard PR.Six ES on 3 areas (Symptoms-Therapies, Aids, Mood) were applied...
Botulinum toxin A (BoNT/A) is the first-line treatment for idiopathic cervical dystonia (ICD) and widely used in clinical setting. To date, scanty data are available on effectiveness of BoNT treating acquired (ACD). Here we present a long-term follow-up ACD patients treated with BoNT/A that focused safety efficacy. The study included subjects who had received at least six treatments three commercially drugs [abobotulinumtoxinA (A/Abo), incobotulinumtoxinA (A/Inco) onabotulinumtoxinA...
Blinking analysis contributes to the understanding of physiological mechanisms in healthy subjects as well pathophysiological neurological diseases. To date, blinking is assessed by various neurophysiological techniques, including electromyographic (EMG) recordings and optoelectronic motion analysis. We recorded eye-blink kinematics with a new portable device, EyeStat (Generation 3, blinktbi, Inc., Charleston, SC, USA), compared measurements data obtained using traditional laboratory-based...
Abstract No studies have investigated voluntary movement abnormalities and their neurophysiological correlates in patients with parkinsonism due to inherited primary monoamine neurotransmitter (NT) disorders. Nine NT disorders 16 healthy controls (HCs) were enrolled. Objective measurements of repetitive finger tapping obtained using a motion analysis system. Primary motor cortex (M1) excitability was assessed by recording the input/output (I/O) curve motor-evoked potentials (MEP)...
Abstract Deep brain stimulation (DBS) is an established therapeutic option for Parkinson Disease (PD), with demonstrated efficacy on motor symptoms also in patients carrying GBA1 variants (GBA-PD). However, it was recently suggested that DBS may accelerate cognitive decline this frequent genetic subgroup, raising major concerns its indication. Primary aim of study to investigate the possible additive effects genotype and implant deterioration other non-motor features long term. As secondary...