A5070797699- Lymphatic System and Diseases
- Endodontics and Root Canal Treatments
- Autoimmune and Inflammatory Disorders Research
- Neuropeptides and Animal Physiology
- Dental Trauma and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Vascular Malformations and Hemangiomas
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
- Injury Epidemiology and Prevention
- Dental Radiography and Imaging
- Adolescent and Pediatric Healthcare
- Pain Mechanisms and Treatments
- Dental materials and restorations
- Dental Research and COVID-19
- Rheumatoid Arthritis Research and Therapies
- Angiogenesis and VEGF in Cancer
- Oral and gingival health research
- Pediatric health and respiratory diseases
- Dental Erosion and Treatment
- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Planarian Biology and Electrostimulation
University of Bergen
2016-2025
Western Norway University of Applied Sciences
2017-2025
Bergen Kommune
2020-2022
National University of Singapore
2001
University of North Carolina at Chapel Hill
1999
University of North Carolina Health Care
1999
Remodelling of the periodontium after application mechanical forces constitutes basis clinical orthodontics and various immunoregulatory molecules are involved in this process. The aim study was to investigate expression cytokines interleukin‐1 α (IL‐1 ) tumor necrosis factor‐ (TNF‐ dental tissues during early phases orthodontic tooth movement. Eightteen male Wistar rats were used. All maxillary right first molars moved orthodontically, with a force 0.5 N, for 3 h, 1 d, d. contralateral...
Most children and adolescents in Norway attend the Public Dental Service (PDS) where they are treated free-of-charge until age of 19 years. Thus, general dentists employed PDS primary care providers for traumatic dental injuries (TDI) young patients. This cross-sectional study assessed knowledge on acute management follow-up TDI its socio-demographic attitudinal covariates.
Due to their peripheral location in the dental pulp and cellular extension into dentin, odontoblasts are first pulpal cells encounter pathogens. The association of with immunoglobulins dendritic during microbial invasion dentin implies that these may possess a role innate adaptive immune responses, however this has not been examined. A pivotal step response is detection foreign antigen recruitment effector area. IL-8 potent chemotactic cytokine plays an important inflammatory response....
The dental pulp consists of loose connective tissue encased in rigid dentinal walls. Because its topography the has low interstitial compliance and limited capacity to expand during fluid volume changes. Due limitations regarding access fluid, basic knowledge on transcapillary transport parameters is lacking for this organ. scope project was dual: first we aimed at establishing a method isolation (IF), second applied rats subjected lipopolysaccharide (LPS)-induced endotoxaemia. aim measure...
ABSTRACT Aim To assess the effect of a dental traumatology educational intervention on general dentists' knowledge. The study was conducted at Vestland County's Public Dental Service (PDS) in Western Norway. Materials and Methods All PDS clinics County ( n = 52) were purposively assigned to control group receiving no (CC, 19), webinar (IC1, 17), combined in‐person physical course (IC2, 16). examine intervention, participants received post‐intervention online questionnaire (Q2) with clinical...
Cytokines act as chemical mediators during the inflammatory process. Measurements of cytokine levels in tissue have previously been performed homogenized tissue, but true concentrations native interstitial fluid (ISF), i.e., compartment where cytokines exert their biologically active role, remained unknown. The role skeletal muscle myocytes a source for endotoxemia was explored by collecting ISF using wick method, and 14 plasma were related to corresponding changes mRNA reveal any potential...
In the well‐vascularized dental pulp vascular endothelial growth factor A ( VEGF ‐A) is expressed. Vascular a member of family, which includes s‐B, ‐C, and ‐D. The latter three have not been investigated in pulp. factors C D are only ligands for receptor VEGFR )‐3, usually expressed lymphatic endothelium. They can also activate ‐2, main angiogenic receptor. We aimed to study s signalling human at gene level identify cellular source protein expression using immunolabelling. All (‐A, ‐B, ‐D)...
ABSTRACT Background/Aim This study explored perceived challenges in the management of traumatic dental injuries (TDI) among general dentists public service (PDS) Vestland County Western Norway and their needs for improving treatment care TDI patients. Participants Methods qualitative conducted three focus group discussions. We recruited a purposive sample seven employed PDS Norway. The groups consisted two, participants, respectively. discussion took place via Microsoft electronic platform...
Lymphangiogenesis, the formation of new lymphatics, is associated with chronic inflammation and tissue injury, its role to enhance lymphatic flow, immune cell transport, antigen clearance. It unknown if lymphangiogenesis takes place during periodontal disease development, we hypothesized that growth vessels occurs in gingiva development periodontitis mice. Inflammation was induced Porphyromonas gingivalis gavage, bone resorption verified after 42 days. Growth blood measured immunofluorescent...
To localize interleukin-1 receptor type I (IL-1RI) in rat dental pulp and trigeminal ganglion (TG) to test the hypothesis that pulpal inflammation increases neuronal expression of IL-1RI.Female Wistar rats were subjected unilateral exposures maxillary mandibular first molars, whereas contralateral jaws served as untreated controls. Seven days later animals transcardiacally perfused TGs removed prepared for immunohistochemistry. Immunoreactivity IL-1RI was examined alone (DAB) together with...
This study aims to evaluate fracture resistance of simulated immature teeth after treatment with regenerative endodontic procedure (REP) using tricalcium silicate cements (TSCs) as cervical plugs. Bovine incisors were sectioned standard crown/root ratio. Pulp tissue was removed and canals enlarged a standardized diameter. Teeth then treated REP protocol consisting NaOCl EDTA irrigation, intracanal medication triple-antibiotic paste for 14 days followed by TSC seal composite restoration....
In the pulp, arteries branch into a capillary network before they leave pulp as venules through apical foramina. The tissue has low compliance, it is enclosed in dentin, and relatively high blood flow volume. interstitial fluid pressure (IFP) colloid osmotic are whereas net driving low. pulsatile IFP probably major force for propelling lymph dental pulp. Vasodilation neighboring well arteriovenous (AV) shunts itself can contribute to fall total coronal pulpal flow, respectively. under...
The lymphatic system is important for immune barrier function and tissue fluid balance. During inflammation, lymphangiogenesis takes place to enhance the transport of filtered fluid, proteins, cells. Dental frequently exposed inflammatory insults, but its responses injury have not been investigated in detail using specific markers. We aimed study this establish whether during wound healing. Immunostaining endothelial hyaluronan receptor‐1 (LYVE‐1) vascular growth factor receptor‐3 (VEGFR‐3)...
Tooth pulp has a dense innervation and rich vascular supply to maintain homeostasis preserve the integrity of tissue. Function, trauma, antigenic challenges make teeth supporting tissues susceptible tissue injury inflammation, partially due lack collateral blood nerve their low compliance. This review focuses on dental functions adaptive changes in pulpal following inflammation peripheral injury. Overviews its development peptidergic oral are presented, followed by discussion central after...
Tricalcium silicate cements ( TSCs ) are used in endodontic procedures to promote wound healing and hard tissue formation. The aim of this study was evaluate compare the effect commonly [mineral trioxide aggregate MTA) , Biodentine, TotalFill] on cellular metabolism osteogenic/angiogenic differentiation human bone marrow mesenchymal stem cells hBMSCs vitro. We tested null hypothesis no difference between MTA TotalFill cell responses. Cells were subjected eluates materials for up 14 d. Cell...
Current knowledge on treatment strategies and choice of restorative materials when treating deep caries or severe dental developmental defects (DDDs) in young individuals is scarce. Therefore, the aim was to investigate Norwegian dentists´ decisions reasons for primary teeth DDDs permanent children.A pre-coded questionnaire sent electronically all dentists employed Public Dental Service (PDS) Norway (n = 1294). The clinicians were asked about their background characteristics how often they...
<i>Objectives:</i> Apical periodontitis is an inflammatory disease characterized by bone resorption, and sympathetic nerves are known to modulate resorption remodeling. Higher numbers of osteoclasts larger periapical lesions have been observed after sympathectomy in rats, but the mechanisms underlying inhibitory effect on unknown. This study aimed test hypothesis that inhibit production bone-resorbing pro-inflammatory cytokines IL-1α TNF-α rat lesions. <i>Methods:</i>...
The gingiva is frequently challenged by oral bacterial products leading to inflammatory responses such as increased fluid filtration and edema formation. role of initial lymphatics for transcapillary balance in the unknown was therefore investigated genetically engineered K14-VEGF receptor 3-Ig (K14) lymphedema mice. mutant mice demonstrated a total lack gingiva, whereas were found submucosal parts alveolar mucosa, although they almost completely absent mucosa. In wild-type (WT) mice,...
Objectives: To collect information on endodontic treatment procedures among dentists in the public dental service (PDS) Western Norway and relate this to their work experience. Materials methods: A survey comprised of 35 questions related personal information, frequency treatment, principles was distributed electronically 187 PDS two counties Norway. Results: The response rate 74%, 130 participated. Among them, 57.0% had completed education less than 13 years ago, almost all were below 39...
To estimate the prevalence of dental erosive wear among five-year-olds in Bergen, Norway, and to investigate associations between background factors condition.A total 387 children received a examination five Public Dental Service clinics Norway. The parents responded items about children's hygiene drinking habits, type beverage container, diet, other their own age, educational level country origin. We explored variables for possible with outcome status as worst affected by (19.4%, n = 75)....
Vitamin D deficiency has been associated with autoimmune diseases and oral health. Knowledge about the association between vitamin status conditions in JIA is limited. We aimed to investigate a cohort of Norwegian children adolescents possible associations serum levels, clinical indicators health, disease characteristics.This multi-center, cross-sectional study, included individuals aged 4-16 years from three geographically spread regions Norway. Demographic data, age at onset, duration,...