The orthodontic mini-implant (OMI) failure often occurs due to the accumulation of peri-implantitis bacteria surrounding it, which results in a stable, resistant form absolute skeletal anchorage during treatment. Administering doxycycline may be solution, but long-term side effects result antibiotic resistance. Roselle flowers (Hibiscus sabdariffa) possess beneficial active phytochemical substances, have potential as an OMI alternative therapy. This study investigates antibacterial activity...

Context: The most common biomaterial used for dental implants is titanium. However, the release of metal ions and risk allergic reactions to metals that may occur in some patients cannot be avoided. Hydroxyapatite-polymethylmethacrylate (HA-PMMA) composite biomaterials are proposed have potential as implant due their mechanical, chemical, biological properties. HA-PMMA induce osseointegration, biocompatible, less reactions, no released. In addition, can obtained from Indonesia’s abundant...

Introduction. Malocclusion is a developmental issue defined by an improper relationship between the two dental arches and teeth. The etiology of malocclusion involves hereditary variables may affect face aesthetics, speech clarity, proper chewing function. There are several translation transcription variations among different human genes, which can be inherited congenitally. Multiple genes such as FGR2, FGR3, DLL3, LFNG, BMPER, skeletal phenotypes. Aim. This study aims to analyze genetic...

ABSTRACT Objective: The aim of this study was to analyze the osteogenic differentiation rat GMSCs cultured in PRF for bone remodeling. Materials and Methods: were isolated from lower gingival tissue four healthy, 250 g, 1-month old, male rats (Rattus norvegicus) cut into small fragments, 2 weeks, subsequently passaged every 4–5 days. passage 3 characterized by CD34, CD45, CD44, CD73, CD90, CD105 using fluorescein isothiocyanate immunocytochemistry (ICC) examination. 3–5 five M24 plates (N =...

Objective: There is a significant difference in post-extraction complications diabetes mellitus (DM) patients as this condition can influence each phase of wound healing due to being delayed. Avocado seeds (Persea americana Mill.) contain many compounds for instance polyphenol catechin compounds, including catechin, cyanidin, chlorogenic acid and quinic that accelerate bone formation after tooth extraction through various mechanism. Bone involve RUNX2 differentiation factor proliferation...

Introduction: One of the parameters for measuring craniofacial growth is suture closure. The sutures are connected with fibrous connective tissue that grows in a few days. objective to analyze gray-scale value (GV) potential by volume interest (VOI) different skulls using micro-computed tomography (Micro-CT). analysis uses certain parameters, namely density and thickness. Material Methods: This study involves experimental mice examine normal development processes at age investigating mice’s...

The roselle flower (Hibiscus sabdariffa) has shown potential as an alternative therapy for bone regeneration. This extract can induce osteoblast maturation, which is crucial forming new bone. study aim was to evaluate the viability of 7F2 preosteoblast cell line following application a nanoemulsion (RNE).This utilized assess (%). RNE oven-dried at 35 40°C 6 hours, resulting in solid extract. then diluted into different concentrations. preparation 1% stirred 1,400 rpm 50°C 90 minutes. Primary...

The aim of the study was to compare ALD results obtained using Huckaba and Moyers methods, including segmentation brass wire techniques, in class I Angle malocclusion Surabayan children during MD GDP at Dental Hospital Universitas Airlangga.This adopted a retrospective cross-sectional design, involving total 252 samples. However, only 32 samples that met inclusion criteria were analyzed for by methods. Sex, chronological age, angle classification recorded. Cervical maturation vertebrae stage...

Abstract Beta-tricalcium phosphate (β-TCP) is a synthetic graft material with excellent biocompatibility, osteoconductivity, and osteoinductivity. β-TCP may induce adipose-derived mesenchymal stem cells (ADMSCs) osteodifferentiation. This study aims to investigate the osteoinductivity of 300 600 1,000μm in ADMSCs. ADMSCs were obtained from visceral adipose tissue young male rabbits. To determine osteoinductive ability, bone morphogenic protein 2 (BMP-2), Osterix, runt-related transcription...

The gingival medicinal signaling cells conditioned medium (GMSCs-CM) is a biocompatible material which possessed beneficial cytokine, anti-microbial peptide, growth factor that can be collected after culture. GMSCs- CM may inhibit bone resorption in order to improve the patient’s quality of life. In this study, potential effect GMSCs-CM on number osteoclasts and osteoblasts Lipopolysaccharide (LPS)-induced calvaria wistar rats (Rattus novergicus) has been analyzed. Twenty-eight male healthy...

<ns4:p><ns4:bold>Background:</ns4:bold>Alveolar bone defect regeneration has long been problematic in the field of dentistry. Gingival stromal progenitor cells (GSPCs) offer a promising solution for alveolar regeneration. In order to optimally differentiate and proliferate cells, growth factors (GFs) are required. Platelet rich fibrin (PRF) many GFs can be easily manufactured. Core-binding factor subunit-α1 (CBF-α1) constitutes well-known osteogenic differentiation transcription SPCs. Sox9,...

Introduction: The dentoskeletal morphology of Class II malocclusion has been analyzed in several cephalometric investigations. It is crucially important to understand the vertical components orthodontic treatment. Defining facial type an individual essential key obtain accurate diagnosis. Aim: aim this study was correlation skeletal malocclusion. Materials and methods: This a observational descriptive study. used lateral cephalograms from Universitas Airlangga Dental Hospital, between April...

Abstract Objectives To investigate the effect of caffeic acid phenethyl ester (CAPE) provision on matrix metalloproteinase-9 (MMP-9), fibroblast growth factor-2 (FGF-2) expression, osteoclast and osteoblast numbers during experimental orthodontic tooth movement (OTM) in male Wistar rats (Rattus norvegicus). Materials Methods Forty-eight healthy (R. norvegicus), 16 to 20 weeks old with 200 250 g body weight (bw) were divided into several groups as follows: K1: OTM for 3 days; K2: 7 K3: 14...

Objective: To investigate the regeneration of rat’s salivary gland diabetic defect after intraglandular transplantation Human Dental Pulp Stem Cells (HDPSCs) on acinar cell vacuolization and Interleukin-10 (IL-10).  Material Methods: HDPSCs isolated from dental pulp first premolars #34. 3rd passage was characterized by immunocytochemistry CD73, CD90, CD105 CD45. Twenty-four male Wistar rats, 3-month-old, 250-300 grams induced with Streptozotocin 30 mg/kg body weight to create diabetes...

The expression of receptor activator Nuclear Factor Kappa Beta (RANK) and its ligand (RANKL), as well osteoprotegrin (OPG), in the alveolar bone (AB), may improve remodeling during orthodontic tooth movement (OTM). It is hypothesized that hypoxia-preconditioned gingival mesenchymal stem cells (GMSC) be more effective than normoxia-preconditioned GMSC this regard. This study aims to investigate RANK, RANKL, OPG compression tension sides AB after allogeneic administration were normoxia or...

Abstract Objectives The aim of this article was to investigate Osterix, ALP, and osteopontin expression in the compression tension sides alveolar bone after application normoxic/hypoxic-preconditioned GMSCs rabbits (Oryctolagus cuniculus) induced with OMF. Materials Methods Forty-eight healthy, young male were divided into four groups: [-] OMF; [+] OMF normoxic-preconditioned; hypoxic-preconditioned. central incisor left mandibular molar experimental animals moved, first moved mesially using...

Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate (EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration vivo. Material Methods: 28 Wistar rats (Rattus Novergicus) was used divided into 4 groups accordingly: K- without EGCG OTM; K+ with OTM, for 14 days; T1with OTM days 7 treatment group 2 (T2) days. animal model...

Orthodontic tooth movement is obtained through alveolar bone remodeling and periodontal tissue in response to the mechanical forces. Epigallocatechin Gallate (EGCG) most abundant bioactive component green tea which promising therapy for remodeling. The aim of study was elucidate effect EGCG expression Nuclear Factor Associated T Cells-1 (NFATC1) sclerostin (SOST) orthodontic animal model. samples consisted 28-healthy male wistar rats (Rattus Novergicus) were randomly selected then divided...

Background: East Javanese green tea or Camellia sinensis is one of the biggest commodities with abundant health benefits. In Indonesia, people drink about 0.35 kg/capita/year approximately 2,781 tons produced in Java. (-)-Epigallocatechin-3-gallate (EGCG), main catechins tea, has anti-cancer, anti-inflammatory, antioxidant, and anti-microbial activities Aim: To analyze EGCG methanolic extract (GTME) using phytochemical analysis, antioxidant activity, screening functional groups, chemical...

Abstract Objective This study aims to confirm whether the GDMSCs isolated from rabbit’s (Oryctolagus cuniculus) gingiva are mesenchymal stem cells (MSCs). Materials and Methods design was partly quasi-experimental with an observational design. were of healthy male rabbits (O. (n = 2), 6 months old, 3 5 kg body weight. The specific cell surface markers MSCs; clusters differentiation (CD), namely, CD44, CD73, CD90, CD105, CD200 expressions; hematopoietic CD34 CD45 examined using flow cytometry...

Context: Alveolar bone remodeling is important to achieve an optimal Orthodontic Tooth Movement (OTM). Runt-related transcription factor 2 (RUNX2) and Osterix (OSX) expression are for remodeling. Green tea (Camelia sinensis) can enhancing Aims: To investigate the effect of a methanolic extract green (MEGT) on OSX RUNX2 during OTM in Wistar rats. Methods: The experiment with post-test only simple random sampling was conducted. samples consisted twenty-eight rats, which were then divided into...

Bone is a dynamic tissue that undergoes remodeling. During bone remodeling, there are transcription factors such as nuclear factor-activated T cells-1 (NFATc1), sclerostin, and tartrate-resistant acid phosphatase (TRAP) released for resorption. Metabolite from gingival mesenchymal stem cells (GMSCs) has the ability to activate proliferation, migration, immunomodulation, regeneration of tissues. Furthermore, aim this study investigate metabolite GMSCs' effect on expression NFATc1, TRAP,...