A5037105855- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Body Contouring and Surgery
- Diversity and Career in Medicine
- Obesity and Health Practices
- Adipokines, Inflammation, and Metabolic Diseases
- Innovations in Medical Education
- Adipose Tissue and Metabolism
- Surgical Simulation and Training
- Advancements in PLL and VCO Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Healthcare Policy and Management
- Healthcare professionals’ stress and burnout
- Gastric Cancer Management and Outcomes
- Hospital Admissions and Outcomes
- Minimally Invasive Surgical Techniques
- Health and Medical Research Impacts
- Real-time simulation and control systems
- Advanced Electrical Measurement Techniques
- Comparative and International Law Studies
- Gastroesophageal reflux and treatments
- Sensor Technology and Measurement Systems
Boston Medical Center
2015-2024
Boston University
2015-2024
Baystate Health
2022-2023
Rhode Island Hospital
2022-2023
University of Vermont Medical Center
2022-2023
Lahey Medical Center
2022-2023
Berkshire Medical Center
2022-2023
Providence College
2022-2023
Maine Medical Center
2022-2023
University of Massachusetts Chan Medical School
2022-2023
Objective— Experimental studies suggest that adipose inflammation is etiologically linked to obesity-induced systemic disease. Our goal was characterize the state of in human fat relation vascular function and metabolic parameters obese individuals. Methods Results— We collected subcutaneous abdominal 77 subjects (BMI ≥30 kg/m 2 ) quantified macrophage population using targeted immunohistochemistry. Brachial artery vasodilator examined high-resolution ultrasound. In 50 subjects, an inflamed...
We previously reported that adenosine monophosphate-activated protein kinase (AMPK) activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant than comparably people sensitive. However, the number patients and parameters studied were small. Here, we compared abdominal subcutaneous, epiploic, omental fat from 16 classified as sensitive or based on homeostatic model assessment resistance. confirmed AMPK diminished group. A custom PCR array revealed increases...
A low-grade state of adipose tissue inflammation associated with obesity has been linked to mechanisms systemic metabolic dysfunction. However, the relation clinical phenotypes depot-specific not well examined in human obesity.To characterize inflammatory status subcutaneous and visceral fat depots, as assessed by presence macrophage crown-like structures (CLS) a hallmark chronic inflammation, determine insulin resistance abnormalities fat.We collected simultaneously from (omental...
The purpose of this study was to characterize the relationship between adipose tissue phenotype and depot-specific microvascular function in fat.In 30 obese subjects (age 42±11 years, body mass index 46±11 kg/m(2)) undergoing bariatric surgery, we intraoperatively collected visceral subcutaneous characterized phenotypes. We assessed vasomotor microvasculature using videomicroscopy small arterioles (75-250 μm) isolated from different fat compartments. Endothelium-dependent,...
Vitamin D is stored in body fat. The purpose of this study was to determine vitamin concentration abdominal fat obese patients who underwent roux-en-Y gastric bypass (RYGB), and describe changes serum 25-hydroxyvitamin (25(OH)D) levels relation loss Subjects from a single clinic were scheduled for RYGB invited into the study. Abdominal subcutaneous, omental, mesenteric obtained at time surgery. Adipose D(2) D(3) concentrations measured by high-performance liquid chromatography (HPLC). Weight...
Background— Experimental studies suggest that visceral adiposity and adipose tissue dysfunction play a central role in obesity-related cardiometabolic complications. Impaired angiogenesis fat has been implicated the development of hypoxia, capillary rarefaction, inflammation, metabolic dysregulation, but pathophysiological mechanisms remain unknown. In this study, we examined novel antiangiogenic isoform vascular endothelial growth factor-A (VEGF-A), VEGF-A 165 b, human obesity. Methods...
Weight loss surgery (WLS) has been shown to produce long-term weight but is not risk free or universally effective. The expectations and willingness undergo perioperative among patients seeking WLS remain unknown.To examine the motivations of mortality risks they are willing undertake explore demographic characteristics, clinical factors, patient perceptions associated with high assume surgical risk.We interviewed conducted multivariable analyses characteristics acceptance 10% higher.Two...
Obesity is associated with increased cardiovascular risk. Although short-term weight loss improves vascular endothelial function, longer term outcomes have not been widely investigated. We examined brachial artery endothelium-dependent vasodilation and metabolic parameters in 29 severely obese subjects who lost > or =10% body (age 45 +/- 13 years; BMI 48 9 kg/m(2)) at baseline after 12 months of dietary and/or surgical intervention. compared these to 14 individuals 49 11 39 7 failed lose...
Accumulation of macrophages and T cells within crown-like structures (CLS) in subcutaneous adipose tissue predicts disease severity obesity-related insulin resistance (OIR). Although rodent data suggest the B cell is an important feature these lesions, have not been described human CLS. In order to identify CLS (sCLS) obese subjects determine whether presence predict resistance, we examined archived samples omental fat from 32 men women related findings clinical parameters. Using...
Morbidly obese individuals are predisposed to a wide range of disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, fatty liver and certain cancers. Remarkably, all these disorders can be improved or prevented by Roux-en-Y gastric bypass (RYGB) surgery. We have reported that decreased AMPK activity, together with increased oxidative stress inflammation in adipose tissue, is associated insulin resistance morbidly bariatric surgery patients. In the current study, we...
In this paper a model for carrier plus narrowband noise is presented, and with its aid the expected number of cycle slipping events per second first-order phase-locked loop (PLL) driven by corrupted carrier, both without limiter, determined. Experimental data are presented which indicate extreme accuracy results obtained use model. The model, based on hypothesis that steps <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\pm2\pi</tex> in phase...
The accumulation of visceral adiposity is strongly associated with systemic inflammation and increased cardiometabolic risk. WNT5A, a non-canonical WNT ligand, has been shown to promote adipose tissue insulin resistance in animal studies. Among other pathways, WNT5A activates planar cell polarity (PCP) signaling. current study investigated the potential contribution WNT5A/PCP signaling (VAT) metabolic dysfunction individuals obesity. VAT subcutaneous (SAT) samples obtained from subjects...
Weight regain (WR) after Roux-en-Y gastric bypass surgery (RYGB) starts to occur 2 years surgery, ultimately affecting at least 25% of patients. A limited number studies have evaluated the impact antiobesity medications (AOMs) on this phenomenon.This study reviewed electronic medical records 1,196 patients who underwent RYGB between 2004 and 2015. WR was by comparing each patient's weight during subsequent postoperative office visits nadir (lowest RYGB, n = 760), taking into consideration...