A5083013192- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Trypanosoma species research and implications
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Insect symbiosis and bacterial influences
- Parasite Biology and Host Interactions
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Aortic Thrombus and Embolism
- Eosinophilic Disorders and Syndromes
- Hemoglobinopathies and Related Disorders
- Helminth infection and control
- Renal and related cancers
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Malaria Research and Control
- RNA and protein synthesis mechanisms
- Radiation Therapy and Dosimetry
- Immune cells in cancer
- Connective tissue disorders research
- Inflammasome and immune disorders
Spanish National Centre for Cardiovascular Research
2020-2025
Universitat de València
2009-2021
Boston University
2013-2018
Scuola Superiore Sant'Anna
2018
Fondazione Toscana Gabriele Monasterio
2018
Temple University
2018
Cardiovascular Institute of the South
2014
Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. Several these recurrent mutations, including those the gene encoding epigenetic modifier enzyme TET2, promote expansion mutant blood This clonal hematopoiesis correlates risk atherosclerotic cardiovascular disease. We studied effects Tet2-mutant cells atherosclerosis-prone, low-density lipoprotein receptor-deficient (Ldlr-/-) mice. found that partial bone marrow reconstitution TET2-deficient...
Human aging is frequently accompanied by the acquisition of somatic mutations in hematopoietic system that induce clonal hematopoiesis, leading to development a mutant clone progenitors and leukocytes. This somatic-mutation-driven hematopoiesis has been associated with an increased incidence cardiovascular disease type 2 diabetes, but whether this epidemiological association reflects direct, causal contribution immune cells age-related metabolic abnormalities remains unexplored. Here, we...
Somatic mutations in the TET2 gene that lead to clonal haematopoiesis (CH) are associated with accelerated atherosclerosis development mice and a higher risk of atherosclerotic disease humans. Mechanistically, these observations have been linked exacerbated vascular inflammation. This study aimed evaluate whether colchicine, widely available inexpensive anti-inflammatory drug, prevents TET2-mutant CH.
Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance obese individuals. Cell culture studies and gain-of-function mouse models suggest that canonical Wnt proteins modulate adipose expansion. However, no genetic evidence supports for endogenous dysfunction, noncanonical signaling remains largely unexplored. Here we provide from human, mouse, cell showing Wnt5a-mediated, contributes to obesity-associated metabolic by increasing inflammation. Wnt5a expression...
Clonal hematopoiesis of indeterminate potential is prevalent in elderly individuals and associated with increased risks all-cause mortality cardiovascular disease. However, mouse models to study the dynamics clonal its consequences on system under homeostatic conditions are lacking. We developed a model using adoptive transfer unfractionated ten-eleven translocation 2-mutant (Tet2-mutant) bone marrow cells into nonirradiated mice. Consistent age-related observed humans, these mice displayed...
Visceral adiposity is much more strongly associated with cardio-metabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting possibility new therapeutic approaches treat obesity and type 2 diabetes. In mice, WAT depots express higher levels browning genes when compared visceral WAT, further that differences could contribute pathogenicity two...
Background FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that upregulated in heart failure (HF) and found to be cardioprotective animal models of cardiac injury. We tested the hypothesis circulating can affect function metabolism under baseline physiological conditions HF. Methods Results was acutely (10 minutes) or chronically (2 weeks) infused attain clinically relevant blood levels conscious dogs with tachypacing-induced Dogs no pacing infusion served as control. 3...
Abstract Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely unknown. Brown adipose tissue (BAT) was initially characterised as thermogenic organ, recent studies have suggested it plays crucial role maintaining systemic metabolic health. While these reports suggest potential link between BAT of dysfunction failure has not been investigated. Here, we demonstrate that alteration function...
Journal Article Clonal haematopoiesis and cardiac arrythmias: rhythm-altering mutations Get access María A Zuriaga, Zuriaga Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro, 3, 28029 Madrid, Spain https://orcid.org/0000-0003-0422-2965 Search for other works by this author on: Oxford Academic PubMed Google Scholar Domingo Pascual-Figal, Pascual-Figal SpainCentro Investigación Biomédica en Red Enfermedades Cardiovasculares, (CIBERCV), SpainHospital...
The accumulation of visceral adiposity is strongly associated with systemic inflammation and increased cardiometabolic risk. WNT5A, a non-canonical WNT ligand, has been shown to promote adipose tissue insulin resistance in animal studies. Among other pathways, WNT5A activates planar cell polarity (PCP) signaling. current study investigated the potential contribution WNT5A/PCP signaling (VAT) metabolic dysfunction individuals obesity. VAT subcutaneous (SAT) samples obtained from subjects...
Obesity is associated with the development of vascular insulin resistance; however, pathophysiological mechanisms are poorly understood. We sought to investigate role WNT5A-JNK in regulation insulin-mediated vasodilator responses human adipose tissue arterioles prone endothelial dysfunction. In 43 severely obese (BMI 44±11 kg/m 2 ) and five metabolically normal non-obese 26±2 subjects, we isolated from subcutaneous visceral fat during planned surgeries. Using videomicroscopy, examined...
The purpose of this study was to determine whether cyclooxygenase inhibition improves vascular dysfunction adipose microvessels from obese humans.In 20 subjects (age 37 ± 12 years, BMI 47 8 kg/m²), subcutaneous and visceral fat were collected during bariatric surgery characterized for depot-specific gene expression, endothelial cell phenotype, microvascular function. Vasomotor function assessed in response endothelium-dependent agonists using videomicroscopy small arterioles fat.Arterioles...
Deep-space travel presents risks of exposure to ionizing radiation composed a spectrum low-fluence protons (1H) and high-charge energy (HZE) iron nuclei (e.g., 56Fe). When exposed galactic cosmic rays, each cell in the body may be traversed by 1H every 3–4 days HZE months. The effects low-dose sequential fractionated or on heart are unknown. In this animal model simulated radiation, middle-aged (8–9 months old) male C57BL/6NT mice were as follows: group 1, nonirradiated controls; 2, three...
Abstract Activation-induced cytidine deaminase (AID) is essential for B cell affinity maturation. We investigated why AID deficiency gives rise to giant germinal centers (GC) using the R112H mouse model that devoid of activity. The increased GC response was associated with accumulation cells in light zone immunized mice. had reduced capacity up-regulate IRF4 initiate plasma differentiation, leading a transitional population GL7 expression. Genetic introduction high receptor (BCR) unable...
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of the joints, leading to bone erosion and joint dysfunction. Despite recent successes disease-modifying anti-rheumatic drugs (DMARDs), there still clinical need for understanding development molecular etiology RA. Wnts are developmental morphogens whose roles in adult pathology poorly characterized. Wnt5a member non-canonical family that modulates wide range cell processes, including...
Triatomine bugs, the vectors of Chagas disease, associate with vertebrate hosts in highly diverse ecotopes. It has been proposed that occupation new microhabitats may trigger selection for distinct phenotypic variants these blood-sucking bugs. Although understanding variation is key to study adaptive evolution and central phenotype-based taxonomy, drivers change diversity triatomines remain poorly understood.We combined a detailed appraisal (including morphology morphometrics) mitochondrial...