A5101863005- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Force Microscopy Techniques and Applications
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- Supramolecular Chemistry and Complexes
- Optical Systems and Laser Technology
- Adaptive optics and wavefront sensing
- Biosensors and Analytical Detection
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Advanced optical system design
- Supramolecular Self-Assembly in Materials
- Cyclopropane Reaction Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- SARS-CoV-2 detection and testing
- Click Chemistry and Applications
- Covalent Organic Framework Applications
- Advanced materials and composites
- Nuclear materials and radiation effects
- Radical Photochemical Reactions
- Alkaloids: synthesis and pharmacology
- CAR-T cell therapy research
- Nanofabrication and Lithography Techniques
Changchun University of Science and Technology
2022-2024
Shanghai Cell Therapy Research Institute
2024
China Railway Construction Corporation (China)
2024
University of Manchester
2016-2023
East China Normal University
2020-2023
Chuzhou University
2023
Beijing Radiation Center
2022
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Zhejiang Chinese Medical University
2020
The gut microbiome is associated with the response to immunotherapy for different cancers. However, impact of on hepatobiliary cancers receiving remains unknown. This study aims investigate relationship between and clinical anti-programmed cell death protein 1 (PD-1) in patients advanced cancers.Patients unresectable hepatocellular carcinoma or biliary tract who have progressed from first-line chemotherapy (gemcitabine plus cisplatin) were enrolled. Fresh stool samples collected before...
Enhancers are a class of cis-regulatory elements that can increase gene transcription by forming loops in intergenic regions, introns and exons. Enhancers, as well their associated target genes, factors (TFs) bind to them, highly with human disease biological processes. Although some enhancer databases have been published, most only focus on enhancers identified high-throughput experimental techniques. Therefore, it is desirable construct comprehensive resource manually curated related...
Electromagnetic pulse (EMP) radiation was reported to be harmful hippocampal neurons. However, the mechanism underlying EMP-induced neuronal damage remains unclear. In this paper, for first time, we attempted investigate involvement of ferroptosis in and its mechanism. vivo studies were conducted with a rat model examine association damage. Moreover, vitro HT22 neurons ferroptosis. results showed that EMP could induce learning memory impairment rats, ferroptotic morphological damages...
Herein, a practical and robust methodology for photoinduced decarboxylative dehydrogenative cross-coupling is reported.
Herein, a practical and efficient tandem cyclization ring-opening coupling of acryloylbenzamides N -arylacrylamides with epoxides is reported.
Spacers linking 2,6-pyridinedicarboxamide units influence the tightness of corresponding lanthanide-coordinated overhand knot. β-Hairpin forming motifs generate a metal-coordinated pseudopeptide with knotted tertiary structure.
In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) vitro and investigate relationship between redox proteins (NOX4, SOD2, GPX2) at tissue cellular levels. As a inhibitor, SGI-1776 inhibited cell proliferation, colony formation, migration induced an increase apoptosis reactive oxygen species two PTC lines (BCPAP TPC-1). The expressions PIM-1, SOD2 GPX2 were downregulated after siNOX4 exposure. Immunohistochemistry 120 patients showed that all four...
Wave-front aberrations due to thermal deformation of elliptical reflectors in periscopic laser communication terminals are studied, and fitted by Zernike polynomials. The relationship between pointing error temperature distribution intersatellite systems is researched. back-fixing method introduced for fixing the reflectors, proven reduce compared traditional around-fixing using a press board. It shown that difference uniform reference has much stronger influence than gradient. For method,...
This work successfully realizes the calculation of both square root and cube consecutive integers within a decimal number “10”, in each result operation, two digits after point are preserved ().
Background: CD19-directed chimeric antigen receptor (CAR) T cells are an important modality for treating adults with relapsed or refractory B-cell acute lymphoblastic leukaemia. We developed a new CAR T-cell therapy, inaticabtagene autoleucel (inati-cel; CNCT19), to improve the rate and duration of remission reduce serious side effects.Methods: This single arm, open-label, pivotal phase 2 study done at 10 centers in China enrolled patients aged 18–65 years diagnosis leukaemia, Eastern...
<title>Abstract</title> Single-level biomarker detection has the limitation of insufficient accuracy in cancer diagnosis. Therefore, strategy developing highly sensitive, multi-channel biosensors for multi-component biomarkers analysis is critical to improve early diagnosis clinical tumors. Herein, order achieve efficient up ten targets ovarian cancer, a DNA-nanoswitch-based (DNA-NSMC) biosensor was built based on multi-module catalytic hairpin assembly-mediated signal amplification (CHA)...
Effect of temperature gradient and uniform on tracking performance reflectors in periscopic laser communication terminals was studied. Zernike polynomials elliptical area were used to fit wave-front aberration due distribution. RMS value the thermal deformation, error intensity detectors degradation at receiving caused by deformation studied inter-satellite system. From result we can know that effect is move peak a little degradation. The reaches 2.9μrad when 14°C/m. will cause variation...