A5101488177- Kawasaki Disease and Coronary Complications
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Stress Responses and Cortisol
- Pediatric Urology and Nephrology Studies
- Cardiac Arrhythmias and Treatments
- Inflammasome and immune disorders
- Radiopharmaceutical Chemistry and Applications
- Acute Myocardial Infarction Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Medical Imaging and Pathology Studies
- Viral Infections and Immunology Research
- Chemokine receptors and signaling
- Cardiac electrophysiology and arrhythmias
- Emergency and Acute Care Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Esophageal and GI Pathology
- Bone health and osteoporosis research
- Congenital Anomalies and Fetal Surgery
Yamanashi Prefectural Central Hospital
2021-2025
University of Yamanashi
2007-2024
University of Yamanashi Hospital
2015-2023
Fujieda Municipal General Hospital
2021-2022
Tohoku Medical and Pharmaceutical University
2005
Osaka University of Pharmaceutical Sciences
2003
University Hospital Cologne
2002
Gunma University
1982
CXCL16 is a new member of the chemokine superfamily, which exists in transmembrane as well soluble form. Its receptor CXCR6 detected on CD4(+) T cells, CD8(+) and natural killer cells. Here, we report significant correlation expression by tumor cells with infiltration prognosis colorectal cancer (CRC). We first found that was consistently up-regulated more tissues than normal mucosa derived from same CRC patients. Four human cell lines also expressed mRNA secreted CXCL16. next examined...
Abstract Introduction In Kawasaki disease (KD), accurate prediction of intravenous immunoglobulin (IVIG) resistance is crucial to reduce a risk for developing coronary artery lesions. Objective To establish simple scoring model predicting IVIG in KD patients based on the machine learning model. Methods A retrospective cohort study 1002 diagnosed at 12 facilities 10 years, which 22.7% were resistant initial treatment. We performed with diverse models using 30 clinical variables diagnosis 801...
Abstract In Kawasaki disease (KD), the effect of plasma exchange (PE) on immune cells has not been fully elucidated. Therefore, we examined changes in number CD14 + CD16 activated monocytes, regulatory T (T reg ), and T‐helper type 17 (Th17) KD patients treated with PE. The percentage total monocytes subclasses lymphocytes, including CD4 CD8 cells, CD19 B showed no significant difference before after However, leukocytes decreased significantly PE (1.1% ± 1.5% vs. 2.1% 2.3%, P < 0.05)....
We have reported that the selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib ('Iressa', ZD1839), suppressed intrahepatic metastasis of hepatocellular carcinoma CBO140C12 cells. In this study, we focused on tumour necrosis factor-α (TNF-α) signalling pathways. Real-time reverse transcription–polymerase chain reaction showed TNF-α mRNA was expressed in large quantities implanted tumour. Gefitinib inhibited EGF- but not hepatocyte (HGF)-induced activation...
The effect of infliximab (IFX) on immune cells has not been fully reported in Kawasaki disease (KD). To investigate the mechanism IFX KD, we examined changes abundance CD14+ CD16+ activated monocytes, regulatory T (Treg ) cells, and T-helper type 17 (Th17) following treatment with IFX.We collected peripheral blood from patients i.v. immunoglobulin (IVIG)-resistant KD analyzed absolute monocyte, Treg (CD4+ CD25+ FOXP3+ Th17 cell IL-17A+ counts flow cytometry. We also measured serum soluble...
Abstract Psychological stress activates the hypothalamus, augments sympathetic nervous output, and elevates blood pressure via excitation of ventral medullary cardiovascular regions. However, anatomical functional connectivity from hypothalamus to regions has not been fully elucidated. We investigated this issue by tract-tracing imaging in rats. Retrograde tracing revealed rostral ventrolateral medulla was innervated neurons ipsilateral dorsomedial (DMH). Anterograde showed DMH projected...
Kawasaki disease is suspected to be triggered by previous infection. The prevention measures for coronavirus 2019 (COVID-19) have reportedly reduced transmission of certain infectious diseases. Under these circumstances, the COVID-19 may reduce incidence disease.We conducted a retrospective study using registration datasets patients with who were diagnosed in all 11 inpatient pediatric facilities Yamanashi Prefecture. eligible cases 595 that before pandemic (from January 2015 through...
Dimethyl sulfoxide (DMSO) has anti-inflammatory and analgesic properties is the only intravesical agent approved by FDA for treatment of interstitial cystitis. While it known that DMSO numerous biological effects on cell differentiation alteration cell-surface carbohydrate structures, mechanism been not clear yet. Therefore, further investigation in terms inflammation therapy needed. This study assessed vitro anti-angiogenic human aorta endothelial cells to clarify one mechanisms its...
Background The aim of the present study was to examine whether stanniocalcin 1 (STC1) affects cardiomyocytes under physiological or pathophysiological conditions. Methods and Results Using fresh isolated rat cardiomyocytes, effects STC1 on cell hypercontracture, shortening Ca2+ transients were measured after exposing cells ouabain. alone did not affect transient. Exposure ouabain significantly increased fraction hypercontractured (40.5±1.4% vs 3.5±1.7% in control, p<0.01). However, treatment...
Post-streptococcal glomerulonephritis (PSGN) generally has a good renal prognosis, and immunosuppressive therapies are not needed. However, few patients present with severe acute kidney injury extensive crescent formations. The etiology of such is well known, involvement anti-neutrophil cytoplasmic antibodies rarely reported. A 9-year-old girl rapidly progressive nephritic syndrome was diagnosed PSGN. biopsy showed diffuse crescentic immunoglobulin G C3 deposits; moreover, humps were...
A multiseptate gallbladder is a very rare congenital malformation in which the lumen divided into variously sized multiseptal compartments. The pathogenesis and natural history of this disease remain uncertain. We herein describe pediatric case with pancreaticobiliary maljunction (PBM), was treated by laparoscopic cholecystectomy.A 5-year-old girl referred to our hospital, because had been incidentally detected on abdominal ultrasonography when she presented for transient pain....
Distal deletion of chromosome 3p25 (also termed as 3p-syndrome) was firstly reported in 1978.1 Since then, this rare disorder has been approximately 50 patients, resulting from congenital distal end 3p. This syndrome is characterized by low birth weight, microcephaly, hypotonia, growth and psychomotor retardation, ptosis and/or blepharophimosis, heart defects, other features.2 In general, chromosomal anomaly arises de novo, breakpoints vary cases.
Abstract Background Several reports have documented that the pulmonary sequestration is in communication with gastrointestinal tract and concept of bronchopulmonary foregut malformation (BPFM) has become more widespread. However, there are few associated pancreas derived from foregut. We describe history pathophysiology BPFM including pancreatic tissue a male infant respiratory distress. Case presentation A patient was born at 38 weeks gestation weighed 2752 g birth. He developed pneumonia...
Most cases of Noonan syndrome (NS) result from mutations in one the RAS-MAPK signaling genes, including PTPN11, SOS1, KRAS, NRAS, RAF1, BRAF, SHOC2, MEK1 (MAP2K1), and CBL. Cardiovascular diseases varying severity, such as pulmonary stenosis hypertrophic cardiomyopathy (HCM), are common NS patients. RAF1 most frequent with HCM, while PTPN11 also well known. Thr73Ile is a gain-of-function mutation which has been highly associated juvenile myelomonocytic leukemia NS/myeloproliferative disease...
Penetrating craniofacial injuries by chopsticks rarely occur in children living Oriental societies.1–3 In many cases, the penetrating accident is caused accidentally holding their hands and can be identified based on stab wound face.1–3 Here we report a case with difficult diagnosis of transorbital intracranial injury child because minor wound.