A5101860191- Reproductive System and Pregnancy
- Gut microbiota and health
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Nuts composition and effects
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Central Venous Catheters and Hemodialysis
- Pregnancy and Medication Impact
- Estrogen and related hormone effects
- PI3K/AKT/mTOR signaling in cancer
- Microbial Metabolic Engineering and Bioproduction
- Endometriosis Research and Treatment
- RNA and protein synthesis mechanisms
- Healthcare professionals’ stress and burnout
- Molecular Biology Techniques and Applications
- Vascular Procedures and Complications
- Uterine Myomas and Treatments
- RNA Research and Splicing
- Simulation-Based Education in Healthcare
- Epigenetics and DNA Methylation
Sichuan University
2021-2025
West China Second University Hospital of Sichuan University
2025
Hebei Medical University
2014-2024
Fourth Hospital of Hebei Medical University
2014-2024
Washington University in St. Louis
2018-2019
Does altering gut microbiota with antibiotic treatment have any impact on endometriosis progression? Antibiotic therapy reduces progression in mice, possibly by reducing specific bacteria. Endometriosis, a chronic condition causing abdominal pain and infertility, afflicts up to 10% of women between the ages 25 40, ~5 million USA. Current strategies, including hormone surgery, significant side effects do not prevent recurrences. We little understanding why some develop others not. Mice were...
Colorectal cancer (CRC) is the third most common and a significant cause of cancer-related mortality globally. Resistance to chemotherapy, especially during CRC treatment, leads reduced effectiveness drugs poor patient outcomes. Long noncoding RNAs (lncRNAs) have been implicated in various pathophysiological processes tumor cells, including chemotherapy resistance, yet roles many lncRNAs remain unclear.
Background Early spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may contribute to ESA, early identification screening risk are increasingly important explore potential etiologies improve prevention treatment strategies for ESA. This study investigates changes in uterine microbiota decidual immune response ESA patients without abnormalities. Methods abnormality...
LncRNA-MIR210HG plays crucial roles in the progression of diverse cancers. However, expression and function MIR210HG ovarian cancer remains unclear. In present study, we aimed to determine lncRNA-MIR210HG under hypoxic conditions. cells conditions was determined by qPCR analysis, distribution FISH analysis based on cell nucleus cytosol RNA extraction. Epithelial-Mesenchymal Transition (EMT) assay human umbilical vein endothelial cell-based tube formation migration assays were employed...
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) mitochondrial DNA (mtDNA) has been described for different types cancers, and association these SNPs with cancer risk disease outcome exhaustively studied. We sequenced a region approximately 1 kb flanking majority D-Loop from blood breast patients controls to identify risk-associated D-loop SNPs. mtDNA was 92 sporadic patients, 60 familial 41 relatives, 93 healthy controls. Paired unpaired Student's...
Totally implantable venous access devices (TIVADs) have been widely used for many years in the management of patients suffering from cancer. Thrombotic occlusion is most common functional complication off-treatment period. This study aims to investigate incidence and risk factors TIVADs-related thrombotic with breast The clinical data 1586 eligible cancer TIVADs at Fourth Affiliated Hospital Hebei Medical University 1 January 2019 31 August 2021 were analysed. was confirmed by angiography...
Catalase is a characteristic enzyme of peroxisomes, which it the most abundant protein. This serves as typical example peroxisomal and important in teaching biochemistry molecular biology. Although there substantial information regarding catalase purification, purifying for junior‑grade undergraduate experimental course face challenges obtaining materials increasingly expensive purification equipment. study presents simple method mouse liver using ethanol‑chloroform treatment, sodium sulfate...
Single nucleotide polymorphisms (SNPs) are accumulated frequently in the mitochondrial displacement loop (D-loop) various types of cancer, and their association with cancer risk disease outcome has been extensively identified. We have identified specific risk-associated SNP for familial breast patients previously. In this study, we investigated between age-at-onset SNPs patients. The sites nucleotides 16 311 T/C were using log-rank test. minor allele C genotype was significantly earlier than...
The failure to treat and control the growth of metastases is main cause death in breast cancer (BC) patients.Compared traditional method analyzing circulating tumor DNA (ctDNA), capturing intact cells (CTCs) allows us more accurately characterize mutations identify suitable targeted therapies.We used CellCollector collect peripheral CTCs.Thirty metastatic (MBC) patients were enrolled, 17 analyzed with nextgeneration sequencing (NGS) methods.Clinical characteristics along CTCs enumeration...
Patient death can be emotionally and psychologically stressful for clinicians, particularly clinicians in training.We describe an annual memorial service as a novel approach to help internal medicine residents cope with reflect on the experiences of patient death.We created 2010 patients who had died under care our institution. Residents, medical students, faculty attended 1-hour service. The was repeated 2011, 10-question survey sent evaluate its impact.Twenty-two participants either or...
Objective: To investigate whether the abundance or diversity of intestinal flora in breast cancer (BC) patients effects on degree tumor infiltration lymphocytes tissues. Methods: Between March 2017 and October 2017, a total 80 biopsy-confirmed female with BC were enrolled present study at Breast Center Fourth Hospital Hebei Medical University (Shijiazhuang, China), age distribution ranged from 37 to 74 years, which divided into three groups based tumor-infiltrating lymphocytes, as follows:...
Abstract To explore the effects of gut microbiota intervention on anti-tumor immune response, Balb/c mice were divided into three groups that administered one following: antibiotics (mixture ampicillin, streptomycin and polymyxin), bifidobacterial or sterile water via oral gavage. Their feces collected for Meta 16S DNA sequencing. The differences in bacteria composition among through β diversity analysis. determine tumor growth, inoculated with 4T1 breast cancer cells, growth was measured...
Abstract Introduction: Metastasis is thought to result from tumour cell entry into the circulation and migration distant organs, where mutation landscape of metastatic breast cancer (MBC) may shift vary. The genotypic features circulating cells (CTCs) typically differ those primary (BC) cells. Gene analysis CTCs in MBC benefit patients by identifying amenable specific therapies. Currently, are primarily isolated vitro small volumes blood. aim this study was isolate vivo using CellCollector...