A5062894790- Cancer Mechanisms and Therapy
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Estrogen and related hormone effects
- Cannabis and Cannabinoid Research
- Breast Lesions and Carcinomas
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Circular RNAs in diseases
- Metastasis and carcinoma case studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Cancer, Lipids, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Electric and Hybrid Vehicle Technologies
- Chemical Synthesis and Analysis
Hebei Medical University
2016-2025
Fourth Hospital of Hebei Medical University
2016-2025
Beijing Fengtai Hospital
2024
Hebei University
2024
Breast Center
2019-2024
Yulin University
2023
Beijing Tsinghua Chang Gung Hospital
2023
Tsinghua University
2023
State Key Laboratory of Vehicle NVH and Safety Technology
2022
Xintai People's Hospital
2022
It has been reported that WIN55212-2, a prototypic aminoalkylindole, higher affinity for CB2 than CB1. To explain the selectivity of WIN55212-2 CB2, molecular modeling studies were performed to probe interacting sites between and cannabinoid receptors. In TMH5 position 5.46 is Phe in versus Val Docking into models CB1 CB2predicts F5.46 will result greater aromatic stacking with WIN55212-2. Using site-directed mutagenesis, this hypothesis was tested by exchanging amino acids at CB2. Two...
Doxorubicin (DOX) is one of the most effective and widely used chemotherapeutic drugs. However, DOX resistance a critical risk problem for breast cancer treatment. Previous studies have demonstrated that metadherin (MTDH) involves in cancer, but exact mechanism remains unclear. In this study, we found glutaminyl-peptide cyclotransferase (QPCT) was MTDH resistance-related downstream gene cancer. Elevated expression QPCT GEPIA database, tissue, cells. Clinical data showed positively associated...
Abstract Background Patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer and primary resistance to trastuzumab have a poor clinical outcome lack good evidence inform decision. This study investigated the efficacy safety of pyrotinib plus capecitabine in this population. Methods phase trial was conducted at 16 sites China. received oral 400 mg once daily 1000 mg/m twice day on days 1–14 each 21-day cycle until disease progression or intolerable...
Nanoparticles (NP) spanning diverse materials and properties have the potential to encapsulate protect a wide range of therapeutic cargos increase bioavailability, prevent undesired degradation, mitigate toxicity. Fulvestrant, selective estrogen receptor degrader, is commonly used for treating patients with (ER)-positive breast cancer, but its broad continual application limited by poor solubility, invasive muscle administration, drug resistance. Here, we developed an active targeting...
Abstract We aimed to analyze the risk factors and construct a new nomogram predict non-sentinel lymph node (NSLN) metastasis for cT1-2 breast cancer patients with positivity after sentinel biopsy (SLNB). A total of 830 who underwent surgery between 2016 2021 at multi-center were included in retrospective analysis. Patients divided into training ( n = 410), internal validation 298), external cohorts 122) based on periods centers. nomogram-based prediction model NSLN was constructed by...
e13109 Background: Breast cancer (BC) is the most common in women, with bones being primary site of metastases (~70%). Bone often lead to skeletal-related events (SREs), adversely impacting patients' quality life and survival. For post-operative BC, timely risk identification, screening, intervention for bone will reduce SREs improve However, formulating personized real-time screening recommendations poses a significant challenge. Our study aimed develop model dynamically predict BC goal...
1031 Background: This study (ChiCTR2000038832) aimed to evaluate the efficacy and safety of combining eribulin with pyrotinib in patients advanced HER2-positive breast cancer who had developed resistance trastuzumab. These typically face a poor clinical prognosis, evidence-based guidance for treatment decisions remains limited. Methods: Eligible were those pathologically confirmed metastatic cancer, an Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1, prior trastuzumab...
Estrogen receptor (ER) and progesterone (PR) have been used as indicators of endocrine system status since the mid-1970s in clinical management breast cancer. The predictive role ER therapy is undisputed, but prognostic value PR still debated. aim this study was to investigate characteristics prognosis positive cancer with different expression levels. A population cohort 3,030 primary invasive patients from a single center underwent surgery received adjuvant 2004 2010. biological features...
The aim of this study was to investigate the association between body mass index (BMI) and prognosis Chinese women with breast cancer.3,380 primary cancer patients who underwent surgery from 2010 2012 were selected classified as low BMI group (BMI < 25.0) high ≥ 25.0). follow-up data for disease-free survival (DFS) overall (OS) obtained 3,178 (median 58 months). Cox regression analysis used evaluate effect on DFS OS.The showed more aggressive pathological features. negatively associated OS...
Background Breast cancer is a leading cause of death in women and with an increasing worldwide incidence. Doxorubicin, as first-line anthracycline-based drug conventional used on breast clinical chemotherapy. However, the resistances limited curative effect doxorubicin therapy patients, but molecular mechanism determinants resistance to chemotherapy are not fully understood. In order explore association between metadherin (MTDH) sensitivity, differential expressions MTDH cell lines...
A characteristic clinical complication in cancer patients is the frequent incidence of thrombotic events. Numerous studies have shown hyperactive/activated platelets to be a critical earlier trigger for cancer-associated thrombus formation. However, there currently no viable approach monitor specific changes tumor-associated platelet activity. Here, we describe chromatograph-like microfluidic device that highly sensitive activity status peripheral circulating both tumor-bearing mice and...
The morphological remodeling of neuronal cells influences neurogenesis and brain functions. We hypothesize that psychoactive neurotoxic effects cannabinoids may be mediated, at least in part, by their morphoregulatory activities. In the present study, mouse neuroblastoma N1E-115 were used as an vitro model to investigate cannabinoid-induced neurite identify involvement cannabinoid receptors this process. Using reverse transcription-polymerase chain reaction immunofluorescence microscopy,...
Abstract Anthracyclines have a profound effect on breast cancer. However, at higher dosages, there are many toxic side effects associated with their use; these include bone marrow suppression, alopecia, gastrointestinal reactions and cardiotoxicity. Pegylated liposomal doxorubicin (PEG-LG) has been demonstrated to achieve equivalent efficacy conventional doxorubicin, significantly lower We conducted an open-label, multicenter, single-armed clinical trial useing NAC regimen based four cycles...
Totally implantable venous access devices (TIVADs) have been widely used for many years in the management of patients suffering from cancer. Thrombotic occlusion is most common functional complication off-treatment period. This study aims to investigate incidence and risk factors TIVADs-related thrombotic with breast The clinical data 1586 eligible cancer TIVADs at Fourth Affiliated Hospital Hebei Medical University 1 January 2019 31 August 2021 were analysed. was confirmed by angiography...
Abstract Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, role of in breast progression its immune microenvironment. Are not clear. A bioinformatic analysis was performed to demonstrate prognostic value BC. In present study, we found that is overexpressed BC significantly correlated with individual stage, age, subclasses, menopause nodal status. overexpression associated a significant decrease OS DSS. Cox multivariate indicated an...
Long noncoding RNAs (lncRNAs) play a significant role in the occurrence and development of malignant tumours. However, ceRNAs, which are significantly associated with prognosis breast cancer (BC), need to be further investigated. Therefore, current study aimed investigate effect lncRNA DDX11-AS1 on BC progression. Bioinformatics analysis via public microarray revealed that was upregulated BC. The above findings were verified RT‒qPCR tissues. Additionally, our expression levels increased...
During the mandibular condylar growth, absorption of calcified cartilage matrix induced by osteoclasts is crucial for continuous endochondral osteogenesis. Meanwhile, recent studies showed that subchondral bone resided within low-oxygen microenvironment, and our previous study revealed hypoxia-inducible transcription factor 1α (HIF-1α) promoted osteoclastogenesis under hypoxia. However, whether HIF-1α regulates function in condyle remains elusive. Our indicated severe deformity was displayed...
MicroRNAs (miRNAs) have been associated with a number of human malignancies, including breast cancer (BC). However, the expression, biological function and fundamental underlying mechanism miR-217-5p in BC remain unclear. Therefore, present study, expression levels metadherin (MTDH) were examined tissues cell lines using reverse transcription-quantitative PCR. Cell Counting Kit-8 assays, proliferation, wound healing Transwell assays western blotting used to examine effects on migration,...
Combined neoadjuvant chemotherapy with trastuzumab and pertuzumab is the standard regimen for human epidermal growth receptor 2 (HER2)-positive breast cancer (BC). However, not available because it on market or covered by medicare in some regions poor economy. Anthracyclines taxanes are cornerstones BC chemotherapy, their combination contributes to satisfactory efficiency settings. Nonetheless, concomitant administration of an anthracycline generally avoided clinically due cardiotoxicity....
Abstract Early reports indicate that metformin, a clinical drug administered to treat type 2 diabetes mellitus (T2DM), was found be associated with better prognosis of cancer. The objective this study retrospectively analyzed the effect metformin on outcomes Chinese breast cancer patients T2DM. A total 3757 primary invasive who underwent surgery from January 2010 December 2013 were enrolled. According medication treatment, all divided as non-diabetes group, group and insulin group. follow-up...
The shift quality of an automatic transmission directly affects the human-perceived comfort and durability transmission. In general, inconsistency caused by manufacturing errors, life-cycle changes, or other changes in hydraulic characteristics are main reason affecting quality, which should be compensated adaptive control shifting process. this paper, we first provide in-depth analysis relationship between proportional solenoid current, clutch pressure, speed torque process control. Then...