A5101621825- Insect behavior and control techniques
- Insect Resistance and Genetics
- Respiratory viral infections research
- Influenza Virus Research Studies
- Forest Insect Ecology and Management
- Genomics and Phylogenetic Studies
- Insect-Plant Interactions and Control
- Plant biochemistry and biosynthesis
- Entomopathogenic Microorganisms in Pest Control
- Insect Pest Control Strategies
- Immune Response and Inflammation
- Genomics, phytochemicals, and oxidative stress
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Sulfur Compounds in Biology
- Glutathione Transferases and Polymorphisms
- Plant and animal studies
- Plant Virus Research Studies
- Plant Gene Expression Analysis
- Pneumonia and Respiratory Infections
- Viral Infections and Immunology Research
- Bacillus and Francisella bacterial research
- Viral Infections and Vectors
Xi'an Jiaotong University
2024-2025
China Agricultural University
2013-2024
Chinese Academy of Inspection and Quarantine
2016-2024
Qingdao Municipal Hospital
2024
Qingdao University
2024
Xinjiang Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Institute of Plant Protection
2024
Northeast Agricultural University
2022-2024
Huazhong Agricultural University
2018-2023
The goal of an AIDS vaccine regimen designed to induce cellular immune responses should be reduce the viral set point and preserve memory CD4 lymphocytes. Here we investigated whether vaccine-induced immunity in absence any Env-specific antibodies can control replication following multiple low-dose challenges with highly pathogenic SIVmac239 isolate. Eight Mamu-A*01-positive Indian rhesus macaques were vaccinated simian immunodeficiency virus (SIV) gag, tat, rev, nef using a DNA...
ABSTRACT The Hexaplex assay (Prodesse, Inc., Milwaukee, Wis.) is a multiplex reverse transcriptase (RT)-PCR for the detection of parainfluenza virus types 1, 2, and 3, respiratory syncytial (RSV) A B, influenza B. We evaluated in comparison with conventional viral cell cultures rapid enzyme immunoassays (EIAs) RSV (Directigen; Becton Dickinson Cockeysville, Md.) (Abbott Test Pack; Abbott Laboratories, Park, Ill.) viruses from pediatric specimens obtained children seen at Children's Hospital...
Community-acquired pneumonia (CAP) and sepsis are important causes of morbidity mortality. We describe the development two molecular assays for detection 11 common viral bacterial agents CAP sepsis: influenza virus A, B, respiratory syncytial A (RSV A), RSV Mycoplasma pneumoniae, Chlamydophila Legionella pneumophila, micdadei, Bordetella pertussis, Staphylococcus aureus, Streptococcus pneumoniae. Further, we report prevalence carriage these pathogens in respiratory, skin, serum specimens...
In addition to sperm motility, which major biological characteristics of fertility potential are associated with mitochondrial functionality?Sperm fertilization capacities, including acrosin activity, acrosome reaction (AR) capability and chromatin integrity, related the mitochondria functionality as evaluated by membrane (MMP).Correlative studies suggest a role MMP in predicting ability ensuring motility. However, researches characterizing other determinants according lacking.The was...
Abstract Since the start of 20th century, many invasive alien species (IAS) have spread rapidly around world, causing serious threats to economies, societies and environment. Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is an important quarantine insect in countries that world over last century. This review collected information on distribution B. explore patterns its invasion expansion. We found be distributed 75 (comprised 124 geographical regions: provinces or states) Asia, Africa,...
The rice stem borer, Chilo suppressalis, is one of the most damaging insect pests to production worldwide. Although C. suppressalis has been focus numerous studies examining cold tolerance and diapause, plant-insect interactions, pesticide targets resistance, development RNAi-mediated pest management, absence a high-quality genome limited deeper insights. To address this limitation, we generated draft constructed from both Illumina PacBio sequences. assembled size was 824.35 Mb with contig...
Current available evidence regarding the detrimental effects of low-level ambient air pollution on conventional semen parameters is inconclusive. In nonreproductive systems, pollutant exposure has been demonstrated to induce oxidative stress (OS), which a crucial mechanism that mediates sperm damage and male infertility. Thus, it may be essential investigate quality in terms perspectives OS relative molecular damage. We assessed associations major stress-mediated alterations semen, including...
The oriental fruit fly Bactrocera dorsalis is one of the most destructive agricultural pests worldwide, with highly debated species delimitation, origin, and global spread routes.Our study intended to (i) resolve taxonomic uncertainties between B. carambolae, (ii) reveal population structure invasion routes across Asia, Africa, Oceania, (iii) identify genomic regions that are responsible for thermal adaptation dorsalis.Based on a high-quality chromosome-level reference genome assembly, we...
Abstract Bactrocera dorsalis is an invasive polyphagous pest causing considerable ecological and economic damage worldwide. We report a high-quality chromosome-level genome assembly combine various transcriptome data to explore the molecular mechanisms of its rapid adaptation new environments. The expansions DDE transposase superfamily key gene families related environmental enrichment expanded unique in metabolism defence response pathways explain adaptability. relatively high but not...
A large outbreak of novel influenza (H1N1) virus (swine origin [S-OIV]) infection in Milwaukee, WI, occurred late April 2009. We had recently developed a rapid multiplex reverse transcription-PCR enzyme hybridization assay (FluPlex) to determine the type (A or B) and subtype (H1, H2, H3, H5, H7, H9, N1 [human], [animal], N2, N7) viruses, this was used confirm diagnoses for first infected patients state. The analytical sensitivity excellent at 1.5 116 copies/reaction, 10(-3) 10(-1) 50% tissue...
Background: Polymerase chain reaction (PCR) assays increase the rate of viral detection in clinical specimens, compared with conventional virologic methods. Studies suggest that PCR may detect virus nucleic acid (NA) persists respiratory tract. Methods: We analyzed data from children having frequent upper infections (URI), who were followed up a longitudinal study. Nasopharyngeal secretions collected at URI onset and when acute otitis media was diagnosed; studies performed using diagnostics...
Background Respiratory Syncytial Virus (RSV) is the leading cause of lower respiratory-tract infections in infants and young children worldwide. Despite this, only six complete genome sequences original strains have been previously published, most recent which dates back 35 26 years for RSV group A B respectively. Methodology/Principal Findings We present a semi-automated sequencing method allowing four whole genomes simultaneously. were able to sequence coding 13 4 from Milwaukee collected...
Lotus japonicus is an important model legume for studying symbiotic nitrogen fixation as well plant development. A genomic sequence of L. (MG20) has been available more than ten years. However, the low quality genome limits its application in functional studies. Therefore, it necessary to assemble high-quality chromosome sequences using new sequencing technology facilitate study genomics. In this report, we used third-generation combined with Illumina HiSeq platform (MG20). We obtained 544...
Conventional influenza vaccines can prevent infection, but their efficacy depends on the degree of antigenic "match" between strains used for vaccine preparation and those circulating in population. A universal based invariant regions virus, able to provide broadly cross-reactive protection, without requiring continuous manufacturing update, would solve a major medical need. Since temporal geographical dominance virus type and/or subtype (A/H3, A/H1, or B) cannot yet be predicted, vaccine,...
Fruit flies in the family Tephritidae are economically important pests that have many species complexes. DNA barcoding has gradually been verified as an effective tool for identifying a wide range of taxonomic groups, and there several publications on rapid accurate identification fruit based this technique; however, comprehensive analyses large new taxa effectiveness rare. In study, we evaluated COI barcode sequences diagnosis using 1426 73 Bactrocera distributed worldwide. Tree-based...
Anthocyanins from black peanut skin could improve the UV-B induced damage mainly through MAPK/Nrf2/HO-1- NQO1-GCLC signaling axis.
Increasing evidence indicates that Nrf-2, named the nuclear factor-erythroid 2-related factor, may perform anticancer function. In this study, a series of novel substituted phenyl- (3-methyl-1H-indol-2-yl)-prop-2-en-1-one (indolyl-chalcone) derivatives were synthesized and their effects on Nrf-2 activity observed. We found compounds 3a-3d 6c elevated activity. Then we evaluated activities in vitro vivo by utilizing human lung cancer cell line A549. The results showed among compounds, 3d...
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is persistently activated in many human tumors including acute myeloid leukemia (AML). Therefore, inhibition of Nrf2 activity may be a promising target therapy. Here, we used an antioxidant response element-luciferase reporter system to identify novel pyrazolyl hydroxamic acid derivative, 1-(4-(tert-Butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H pyrazole-5-carboxamide (4f), that inhibited activity. 4f had profound growth-inhibitory effect on...