A5084934595- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Child and Adolescent Health
- Metabolism and Genetic Disorders
- Airway Management and Intubation Techniques
- Congenital Diaphragmatic Hernia Studies
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical studies and practices
- Infant Development and Preterm Care
- Anesthesia and Neurotoxicity Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Emergency and Acute Care Studies
- Health Promotion and Cardiovascular Prevention
- Respiratory Support and Mechanisms
- Congenital Anomalies and Fetal Surgery
- Cardiac Health and Mental Health
- Connexins and lens biology
- Cardiovascular Issues in Pregnancy
- Transportation and Mobility Innovations
- Homicide, Infanticide, and Child Abuse
- Urban Transport and Accessibility
- Kidney Stones and Urolithiasis Treatments
United Arab Emirates University
2023
Loma Linda University
2023
Imperial College London
2022
Imperial College Healthcare NHS Trust
2022
Yale University
2016
Pfizer (United States)
2016
Hartford Financial Services (United States)
2016
GlaxoSmithKline (United States)
2016
Eisai (United States)
2016
Teva Pharmaceuticals (United States)
2016
To investigate whether inhaling 50% xenon during hypothermia (HT) offers better neuroprotection than or HT alone.Ninety-eight newborn pigs underwent a 45-minute global hypoxic-ischemic insult severe enough to cause permanent brain injury, and 12 sham protocol. Pigs then received intravenous anesthesia were randomized 6 treatment groups: (1) normothermia (NT; rectal temperature 38.5 degrees C, n = 18); (2) 18 hours with NT (n 12); (3) (rectal 33.5 (4) 24 17); (5) (6) 17). Fifty percent was...
The objective of this study was to compare cooling methods during therapeutic hypothermia (TH) for moderate or severe perinatal asphyxia with regard temperature and hemodynamic stability.A total 73 newborns received TH in our center between 1999 2009 by 4 methods: (1) selective head mild systemic using cap (SHC; n = 20); (2) whole-body mattress manually controlled (WBCmc; 23); (3) body wrap servo-controlled (WBCsc; 28); (4) water-filled gloves (n 2). Target rectal temperatures (Trec) were...
The amyloid-<i>β</i> peptide (A<i>β</i>)—in particular, the 42–amino acid form, A<i>β</i>1-42—is thought to play a key role in pathogenesis of Alzheimer's disease (AD). Thus, several therapeutic modalities aiming inhibit A<i>β</i> synthesis or increase clearance have entered clinical trials, including <i>γ</i>-secretase inhibitors, anti-A<i>β</i> antibodies, and precursor protein cleaving enzyme inhibitors. A unique class small molecules, modulators (GSMs), selectively reduce A<i>β</i>1-42...
<i>Background:</i> Post-haemorrhagic ventricular dilatation (PHVD) after intraventricular haemorrhage (IVH) remains a significant problem in preterm infants. Due to serious disadvantages of ventriculoperitoneal shunt dependence, there is an urgent need for non-surgical interventions. Considerable experimental and clinical evidence implicates transforming growth factor β (TGFβ) the pathogenesis PHVD. Colchicine decorin are both compounds with anti-TGFβ properties. The former...
Introduction Cardiovascular disease (CVD) is the most common cause of death both globally and in United Arab Emirates. Despite public health measures education, rates from CVD remain stable. Barriers previously identified to lifestyle changes include cultural reasons, boredom, lack family support. The Emirates Heart Health Project (EHHP) seeks support healthy through a family-based intervention using coach fitness tracker. Methods analysis EHHP stepped-wedge cluster-randomized trial with...
Therapeutic hypothermia after perinatal asphyxia decreases brain injury in newborns, whereas hyperthermia worsens the injury. We examined how different clinical practices influence regional temperatures during hypothermia.Six newborn pigs, which have comparable physiology and maturation to human term infants, were maintained at (33.5°C) or normothermia with a servo-controlled whole-body cooling device that is use. Pigs anesthetized fully instrumented for cardiovascular temperature (rectal...
We describe a child from consanguineous family born with rare autosomal recessive disorder affecting junctional adhesion molecule 3 (JAM3) causing profound neurological and ophthalmological injury known as haemorrhagic brain destruction, subependymal calcifications, congenital cataracts (HDBSCC; MIM# 613730). She was the product of an unremarkable pregnancy near to term but noted shortly after birth have cataracts, poor vision, increased muscle tone, seizures, developmental delay. Her older...
<h3>Context</h3> Neonatal care delivered by ST1 Paediatric trainees attached to 18 Local Units and Special Care Baby Units. <h3>Problem</h3> Trainees did not feel adequately prepared or supported perform essential duties of their role including attending deliveries performing newborn examinations. highlighted the risks patient safety quality care. <h3>Assessment problem analysis its causes</h3> To quantify understand root causes we interviewed surveyed 48 after completing first post with...