A5043130157- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- COVID-19 Impact on Reproduction
- Ectopic Pregnancy Diagnosis and Management
- Preterm Birth and Chorioamnionitis
- Prenatal Screening and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Gynecological conditions and treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Homicide, Infanticide, and Child Abuse
- COVID-19 and healthcare impacts
- Global Maternal and Child Health
- Toxoplasma gondii Research Studies
- Intimate Partner and Family Violence
- Reproductive System and Pregnancy
- Neonatal and fetal brain pathology
- Neonatal and Maternal Infections
- Blood groups and transfusion
- Breastfeeding Practices and Influences
- Heme Oxygenase-1 and Carbon Monoxide
Ljubljana University Medical Centre
2015-2024
University of Ljubljana
2016-2024
Institute Of Perinatology Obstetrics And Gynaecology
2013
Blood Transfusion Centre of Slovenia
2012
Očesna Klinika UKC Ljubljana
2003
The COVID-19 pandemic threatens the impact of cervical cancer screening and global elimination goals. As programmes were adjusting to new situation, we evaluated intensity, quality, outcomes in Slovenia first seven months pandemic.Historical observational study on data from a population-based registry. Number cytopathology (screening follow-up), histopathology (diagnostic procedures, invasive procedures number newly diagnosed CIN2+ cases) HPV test results entire Slovenian women population...
of recommendationsCorticosteroids should be administered to women at a gestational age between 24+0 and 33+6 weeks, when preterm birth is anticipated in the next seven days, as these have been consistently shown reduce neonatal mortality morbidity. (Strong-quality evidence; strong recommendation). In selected cases, extension this period up 34+6 weeks may considered (Expert opinion). Optimal benefits are found infants delivered within 7 days corticosteroid administration. Even single-dose...
A 36-year-old woman acquired severe human granulocytic anaplasmosis after blood transfusion following a cesarean section. Although intensive treatment with mechanical ventilation was needed, the patient had an excellent recovery. Disease caused by Anaplasma phagocytophilum infection confirmed in 1 donor and recipient.
The etiology of preterm birth (PTB) is heterogeneous and not yet well known. Maternal periodontal disease has been investigated for decades a known risk factor adverse pregnancy outcomes. However, no particular bacterial species or higher taxonomic order found as causative PTB, leading to studies the whole oral microbiome. In determine if how composition microbiome associated with we performed large case-control study including women term (TB) PTB.We compared microbiomes in PTB TB, examine...
A programme for the prevention of congenital toxoplasmosis in Slovenia involving screening pregnant women Toxoplasma infection is presented. Of 21,270 screened between, 1996 and end 1999, 13,987 (66%) were seronegative, 7,151 (34%) seropositive 132 had primary infection; approximately 9/1,000 at risk acquiring infection. One hundred live-born infants infected available follow-up. Nine but asymptomatic children born to mothers who treated time two congenitally babies whom was detected too...
Abstract Background Identifying the risk factors for preeclampsia (PE) is essential implementation of preventive actions. In present study, we aimed at exploring association between total gestational weight gain (GWG) and PE. Methods We performed a population-based cohort survey 98,820 women with singleton pregnancies who delivered in Slovenia from 2013 to 2017. Aggregated data were obtained National Perinatal Information System (NPIS). The main outcome measure was incidence exposure...
To determine whether neutrophil defensins (HNP1-3) and interleukin-6 (IL-6) in vaginal fluid after preterm premature rupture of membranes predict fetal inflammatory response syndrome (FIRS), neurological impairment or chorioamnionitis.Prospective study.Tertiary referral university hospital.Forty-two patients with at <32 weeks.Levels HNP1-3 IL-6 were measured obtained by swabs. Mann-Whitney U-test was used to compare levels groups vs. without FIRS, infant death impairment, chorioamnionitis...
Abstract Objective: To explore the associations between birth weight for gestational age (GA) and infant mortality as well causes of death. Study design: A population-based observational study conducted 2002 2012 included 203,620 non-malformed singleton live births from Slovenia. Poisson regression analyses were performed to estimate crude relative risk (RR) adjusted RR (aRR) by percentiles stratified GA subgroups term, moderate-to-late preterm, very preterm extremely preterm. Results:...
Depression, anxiety and fear of childbirth have numerous consequences for women their developing offspring. Insecure attachment in close adult relationships is considered to be a risk factor depressive symptoms. This study aims gain further insight into the factors symptoms nulliparous during third trimester pregnancy regarding main contextual relations, with an emphasis on partner attachment.
<b><i>Objective:</i></b> The aim of this work was to define a differential marker profile for pregnancy complications near delivery. <b><i>Methods:</i></b> We enrolled pregnant women who were referred the outpatient clinic University Medical Center, Ljubljana, Slovenia, due symptoms and with history attending high-risk hospital close surveillance. They evaluated prior risk tested biophysical biochemical markers at time enrolment. Biochemical...
To evaluate effectiveness and safety of therapeutic plasma exchange (TPE) dextran-sulfate adsorption (DSA) for extracorporeal removal soluble Fms-like tyrosine kinase-1 (sFlt-1) as part expectant management preeclampsia at extremely preterm gestational age.Retrospective case series six patients with <28 weeks gestation, treated DSA or TPE. Laboratory results, clinical characteristics neonatal outcomes were collected from charts National Perinatal Information System.Fetal growth restriction...
To calculate a population-based prospective risk of fetal death in monochorionic-diamniotic twins.We evaluated 387 twin pregnancies that were followed and delivered after 24 weeks Slovenia during the period 1997-2007. Surveillance was not standardized. The calculated as total number deaths beginning gestational divided by continuing at or beyond period.Fetal rate 32 774 fetuses (4.1%; 95% confidence interval (CI), 3.0%-5.9%); stillbirth per pregnancy 33 gestation 6.2% (95% CI, 4.2%-9.1%).The...
To explore correlations between the sFlt-1/PlGF ratio and uterine arteries (UtA) Doppler indexes in placental dysfunction-related disorders (PDD).We prospectively included women with a singleton pregnancy preeclampsia (PE) only (n = 22), fetal growth restriction (FGR) 32), FGR 12), or normal 29).In PDDs, significantly positive mean UtA pulsatility (mPI-UtA), as well resistance index (mRI-UtA) were found (p 0.015, p 0.019, respectively), but not pregnancies. PDD signs of impaired...
Objective: The aim of this study was to establish early pregnancy risk indicators for spontaneous twin very preterm birth.Methods: We conducted a retrospective observational population-based study. Twenty-one potential factors were analyzed using multivariable logistic regression determine which them independently associated with birth.Results: Of 1815 births 15.3% (277) occurred before 32 weeks. Previous delivery (aOR 3.73; 95% CI, 2.52–5.52), nulliparity 2.94; 2.09–4.14), body mass index...
Abstract STUDY QUESTION Is preterm delivery an infertility treatment-related adverse outcome in infertile women who conceived after reproductive surgery? SUMMARY ANSWER Compared with matched fertile women, appears to be a modest have surgery then naturally or IVF/ICSI. WHAT IS KNOWN ALREADY Most observational studies shown that receive any treatment are more likely deliver than do women. However, on the of pregnancies conceive scarce. DESIGN, SIZE, DURATION This was single-centre historical...
For a significant proportion of women, postpartum depression (PPD) is the first mood episode in their lives, yet its aetiology still remains unclear. Insecure attachment close adult relationships considered to be risk factor for depressive symptoms. This study aimed gain further insight into factors symptoms (PPDS) nulliparas Slovenia and examine vulnerability developing symptoms, with an emphasis on contextual stress-related characteristics.The sample consisted 156 third trimester pregnancy...
To evaluate the impact of prenatal screening and genetic testing for trisomy 21 (T21) on prevalence T21 in Slovenia.Data about all prenatally postnatally confirmed cases Slovenia between 1981 2012 were collected retrospectively from laboratories Slovenia. The expected number babies with according to maternal age was calculated.The primary outcomes measures fetuses newborn infants diagnosed advances diagnostics newborns Slovenia.Despite a significantly increased mean 25.4 years year 30.3 0.51...
We demonstrate the nonlinear severity of symptoms SARS-CoV-2 infection in mother leading to fetal death after acute placental failure.Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation a viable virus, and autopsy with histologic results were used investigate possible vertical transmission from fetus.Histologic changes placenta correlate infection. Total nucleic acid isolated vaginal swabs, fresh tissue, deparaffinized tissue showed high viral load...