A5040339609- Pain Mechanisms and Treatments
- Circadian rhythm and melatonin
- Drug Transport and Resistance Mechanisms
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Immunotherapy and Biomarkers
- Pregnancy and Medication Impact
- Vascular anomalies and interventions
- Cannabis and Cannabinoid Research
- Cancer Treatment and Pharmacology
- Carcinogens and Genotoxicity Assessment
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Ion Channels and Receptors
- Lung Cancer Treatments and Mutations
- Pharmacological Effects and Toxicity Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Sulfur Compounds in Biology
- Folate and B Vitamins Research
- Dietary Effects on Health
- Pharmacological Receptor Mechanisms and Effects
- Coronary Artery Anomalies
Kyushu University
2018-2025
Kyushu University Hospital
2024
Sanyo-Onoda City University
2023
Nagano Children's Hospital
2012
Neuropathic pain is one of the most intractable conditions associated with tumor growth compressing and damaging nerves. A troublesome hallmark symptom neuropathic hypersensitivity to innocuous stimuli, known as “tactile allodynia,” which often refractory currently available analgesics. Diurnal variations in are common patients cancer, but underlying mechanisms enigmatic. Herein, we report that spinal expression lipocalin-2 (LCN2) enhances sensitivity NCTC2472 fibrosarcoma-implanted male...
A problem for patients with diabetes is the rise of complications, such as peripheral neuropathy, nephropathy and retinopathy. Among them, characterized by numbness and/or hypersensitivity to pain in extremities, likely develop early stages diabetes. Empagliflozin (EMPA), a sodium-glucose cotransporter-2 inhibitor, exerts hypoglycemic effects preventing glucose reabsorption proximal tubular cells. EMPA can improve cardiovascular renal outcomes diabetic patients, but its suppressive effect on...
The metabolic reprogramming of amino acids is critical for cancer cell growth and survival. Notably, intracellular accumulation cysteine often observed in various cancers, suggesting its potential role alleviating the oxidative stress associated with rapid proliferation. liver primary organ biosynthesis, but much remains unknown about alterations their mechanisms hepatocellular carcinoma cells. RNA-seq data from patients hepatocarcinoma were analyzed using TNMplot database. underlying...
Abstract The expression and function of some xenobiotic transporters varies according to the time day, causing dosing time-dependent changes in drug disposition toxicity. Multidrug resistance-associated protein-4 (MRP4), an ATPbinding cassette (ABC) efflux transporter encoded by Abcc4 gene, is highly expressed bone marrow cells (BMCs) protects them against xenobiotics, including chemotherapeutic drugs. In this study, we demonstrated that MRP4 was responsible for extrusion oxaliplatin...
Prostaglandins are bioactive compounds, and the activation of their receptors affects expression clock genes. However, prostaglandin F receptor (Ptgfr) has no known relationship with biological rhythms. Here, we first measured locomotor period lengths Ptgfr-KO (B6.129-Ptgfrtm1Sna) mice found that they were longer under constant dark conditions (DD) than those wild-type (C57BL/6J) mice. We then investigated gene patterns within suprachiasmatic nucleus in DD observed a decrease cryptochrome 1...
Abstract Neuropathic pain often results from injuries and diseases that affect the somatosensory system. Disruption of circadian clock has been implicated in exacerbation neuropathic state. However, this study, we report mice deficient a core component Period2 (Per2m/m mice) fail to develop tactile hypersensitivity even following peripheral nerve injury. Similar male wild-type mice, partial sciatic ligation (PSL)-Per2m/m showed activation glial cells dorsal horn spinal cord increased...
Background The immune-related adverse event (irAE), pneumonitis, is a potentially fatal complication of immune checkpoint inhibitors (ICIs). Preventing its progression crucial, emphasizing the need for effective screening tests. We evaluated feasibility using Krebs von den Lungen-6 (KL-6), marker interstitial as tool pneumonitis. Methods examined 500 patients with cancer divided into two groups: those other than non-small cell lung (NSCLC) (Group 1, n=382) and NSCLC 2, n=118). KL-6 levels...
We ranked the haemodynamics and pulmonary artery (PA) configurations of Norwood with bidirectional Glenn shunt (NW-G) patients among other staged Fontan completion (conventional) in this study. Between August 2001 April 2010, 91 consecutive completed operations. Among them, NW-G was performed 11. There no operative or late death except one case which resulted from a reoperation after completion. Although age at (BDG) younger (4.2 vs. 10.9 months, P < 0.01, 2.3 3.3 years, 0.01), interval...
In addition to diurnal rhythms in physiology and behavior, a variety of pathological conditions also exhibit marked day-night changes symptom intensity, exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke chronic pain disorders. Currently, novel therapeutic approaches are facilitated the development chemical compounds targeted key proteins that cause exacerbation events. Neuropathic is condition occurs tumor-induced nerve compression,...
Neuropathic pain associated with cancers is caused by tumor growth compressing and damaging nerves, which would also be enhanced inflammatory factors through sensitizing nociceptor neurons. A troublesome hallmark symptom of neuropathic hypersensitivity to innocuous stimuli, a condition known as "tactile allodynia", often refractory NSAIDs opioids. The involvement chemokine CCL2 (monocyte chemoattractant protein-1) in cancer-evoked well established, but opinions remain divided whether...
Because the expression of up to 10% genes is under control circadian machinery consisting clock genes, it should not come as a surprise that disfunction gene affects onset and/or state various disease. Diurnal variations in pain hypersensitivity are common chronic disorders, but pathological relevance neuropathic remains unknown. In this study, we investigated threshold mechanical peripheral sciatic nerve-ligated (PSL) animals and found deficient mice (Per2m/m mice) failed develop...
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.