A5103055517- Complement system in diseases
- Blood groups and transfusion
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- 2D Materials and Applications
- Photochromic and Fluorescence Chemistry
- Synthesis and properties of polymers
- Liver Disease and Transplantation
- X-ray Spectroscopy and Fluorescence Analysis
- Adenosine and Purinergic Signaling
- Analytical chemistry methods development
- Advanced Thermoelectric Materials and Devices
- Advanced X-ray Imaging Techniques
- Renal Diseases and Glomerulopathies
- Multiple Myeloma Research and Treatments
- RNA Interference and Gene Delivery
- Erythropoietin and Anemia Treatment
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Metal and Thin Film Mechanics
- Synthesis of Tetrazole Derivatives
- Coffee research and impacts
- Polymer composites and self-healing
- Fiber-reinforced polymer composites
Industrial Technology Research Institute
2020-2024
National Institute for Materials Science
2018-2023
National Cheng Kung University
2017
University of Notre Dame
1972
There is a growing interest in the development of dynamic adaptive biomaterials for regulation cellular functions. However, existing materials are limited to two-state switching presentation and removal cell-adhesive bioactive motifs that cannot emulate native extracellular matrix (ECM) vivo with continuously adjustable characteristics. Here, tunable composed protein monolayer assembled at liquid-liquid interface demonstrated, which adapt dynamically cell traction forces. An ultrastructure...
Abstract The Phase 3 single‐arm COMMODORE study ( ClinicalTrials.gov , NCT04654468) evaluated efficacy and safety of crovalimab (novel C5 inhibitor) in complement inhibitor‐naive patients with paroxysmal nocturnal hemoglobinuria (PNH). enrolled from five China centers. Eligible PNH were ≥12 years old, had lactate dehydrogenase (LDH) ≥2 × upper limit normal (ULN), ≥4 transfusions packed red blood cells within the prior 12 months. Patients received loading doses (one intravenous, four...
Patients with end-stage kidney disease (ESKD) rely on dialysis to remove toxins and stay alive. However, hemodialysis alone is insufficient completely all/major uremic toxins, resulting in the accumulation of specific over time. The complexity their varying clearance rates across different modalities poses significant challenges, innovative approaches such as microfluidics, biomarker discovery, point-of-care testing are being investigated. This review explores recent advances qualitative...
Collective migration is the mechanobiological interplay within migrating cell clusters and against extracellular matrixes (ECMs) underneath, mediating various physiological pathological processes. Therefore, it crucial to develop a robust platform on which collective can be studied under standardized conditions understand how cells migrate differently between normal disease states. We herein demonstrated phtotoactivatable hydrogel interfaces as suitable candidates for such applications. The...
There is growing evidence that cellular functions are regulated by the viscoelastic nature of surrounding matrices. This study aimed to investigate impact interfacial viscoelasticity on adhesion and epithelial-mesenchymal transition (EMT) behaviors epithelial cells. The was manipulated using spin-coated thin films composed copolymers ε-caprolactone d,l-lactide photo-cross-linked with benzophenone, whose mechanical properties were characterized atomic force microscopy a rheometer. critical...
TPS8069 Background: Treatment of relapsed/refractory (R/R) multiple myeloma (MM) is challenging, especially in later lines where drug resistance reduces therapeutic options and remission duration. Prognosis poor (estimated survival: < 1 year) for patients with MM who have received > 3 prior therapy are triple refractory to immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs) anti-CD38 agents (Gandhi et al. 2019). Thus R/R constitutes a significant unmet medical need. Fragment...
The non-canonical photoisomerization-induced phase separation of an azobenzene-bearing polymer is found. composed acrylate-based azobenzene (AzoAA) and N,N-dimethylacrylamide (DMA), namely poly(AzoAA-r-DMA), separates under visible light-induced cis-to-trans isomerization at high molecular weight, whereas the realized UV trans-to-cis low weight. Conventionally, origin believed to arise from difference in polarity between apolar trans polar cis states; thereby direction changes, either...
The tellurene flakes display outstanding structure stability over 30 days under ambient exposure and reveal the abnormal thermal conductance across grain boundary by exploiting SThM.
Topic: 12. Bone marrow failure syndromes incl. PNH - Clinical Background: The primary analysis of the Phase 3 multicenter single-arm COMMODORE (NCT04654468) trial studying crovalimab (a novel C5 inhibitor) in inhibitor-naive pts with China reported that both co-primary endpoints hemolysis control and transfusion avoidance were met, no new safety signals (Liu ASH 2022). Aims: Report updated data an additional 6 months exposure. Methods: study enrolled Chinese who ≥12 years, ≥40 kg, had...
The semiconductor industry continues to shrink the device sizes while applying more complex shapes and using diverse materials, which requires parallel improvements in quality of ultrapure reagents. need for reagents has led ever-higher demands performance analytical instruments used detect ultratrace impurities. In this study, nonvolatile impurities were quantified a scanning mobility particle sizer (SMPS). performances three different sample introduction systems, i.e., an electrospray...
Abstract m-Bisaccharin and related derivatives were polymerized with 3, 3′-diaminobenzidine in melts solutions dimethylacetamide polyphosphoric acid. All products formed possessed open-chain, polyamide structures. These hemipolymers, viscosities ranging to 1.45 dl/g concentrated sulfuric acid, could be cyclized by heating their triethylammonium salts 420°C. The polythiazones isolated from such reactions exhibited good thermal stability. Heating of the hemipolymers themselves, rather than...
The notion of an effective longitudinal coherence length with its value much greater than λ2/(2Δλ) has been adopted in small-angle X-ray scattering communities for years, where λ and Δλ denote the incident wavelength spread, respectively. Often implications do not even enter considerations designing data treatment experiments. In this work, conventional transmission (tSAXS) was performed to reveal a clear angular dependence on length. measured values can be as high one millimeter, whereas...