A5102765582- Plant-derived Lignans Synthesis and Bioactivity
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Microbial infections and disease research
- Virology and Viral Diseases
- Tryptophan and brain disorders
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- interferon and immune responses
- Polyamine Metabolism and Applications
- Bacteriophages and microbial interactions
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
Chinese Academy of Agricultural Sciences
2021-2025
Jilin Academy of Agricultural Sciences
2024
Academy of Military Medical Sciences
2013-2024
Jilin University
2021-2022
Northeast Normal University
2021
Sichuan Agricultural University
2021
Changzhou No.2 People's Hospital
2016-2019
Abstract We report an outbreak of canine distemper virus (CDV) infection among endangered giant pandas ( Ailuropoda melanoleuca ). Five six CDV infected died. The surviving panda was previously vaccinated against CDV. Genomic sequencing isolated from one the (giant panda/SX/2014) suggests it belongs to Asia-1 cluster. hemagglutinin protein and sequenced lung samples originating deceased all possessed substitutions V26M, T213A, K281R, S300N, P340Q, Y549H. presence Y549H substitution is...
Between January 2012 and March 2012, the infection rates of porcine epidemic diarrhea virus (PEDV) increased substantially in vaccinated swine herds many farms Gansu Province, China. The spike (S) glycoprotein is an important determinant for PEDV biological properties. To determine distribution profile outbreak strains, we sequenced full-length S gene five samples from two where animals exhibited severe high mortality rates. Five new variants were identified, molecular diversity,...
H4Nx avian influenza viruses (AIVs) have been isolated from wild birds and poultry can also cross the species barrier to infect mammals (pigs muskrats). The widespread presence of these in their ability be transmitted interspecies make them an undeniable hazard farming industry. In present study, we collected fecal swab samples Guangdong Province January 2019 March 2024, various subtypes AIVs were isolated, including 19 strains H4 subtype AIVs. Further analysis was conducted on internal...
Influenza virus causes worldwide outbreaks and seasonal epidemics, posing a severe threat to public health social development. Effective prevention treatment of influenza infections remain major challenge for global healthcare. In this study, we observed that taurolidine effectively inhibited the proliferation several human or animal strains protected mice from lethal-infection. Taurolidine decreased viral titer in lungs infected mice, reduced ratio immune cells, alleviated lung pathology....
Newcastle disease virus (NDV) causes a highly contagious viral in poultry and wild birds, it can cause significant economic loss worldwide. Eight strains were isolated by inoculating embryonated chicken eggs from the Poyang Lake region of China with swab samples. All eight NDV isolates identified as class I genotype 3 strains, but they diverged notablely II viruses. Further analysis revealed that all lentogenic containing 112ERQER↓L117 motif at F protein cleavage site. The identical more...
Kobuviruses comprise three species, the Aichivirus A, B, and C (porcine kobuvirus). Porcine kobuvirus is endemic to pig farms not restricted geographically but, rather, distributed worldwide. The complete genomic sequences of four porcine strains isolated during a diarrhea outbreak in piglets Gansu province China were determined. Two these exhibited variations relative traditional strains. potential 3C/3D cleavage sites variant Q/C, which differed from Q/S genome. A 90-nucleotide deletion 2B...
Taurolidine (TRD), a derivative of taurine, has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls, endotoxins exotoxins to inhibit the adhesion microorganisms. However, its application in antiviral therapy is seldom reported. Here, we reported that TRD significantly inhibited replication influenza virus H5N1 MDCK cells half-maximal inhibitory concentration (EC50) 34.45 μg/mL. Furthermore, drug amplification cytokine storm effect improved survival rate mice lethal...
Influenza virus is prone to seasonal spread and widespread outbreaks, which pose important challenges public health security. Therefore, it effectively prevent treat influenza infection. Schisandra polysaccharide (SPJ) a derived from the fruit of chinensis (Turcz.) Baill. In this study, we evaluated antiviral activity SPJ in vitro vivo , especially against A (IAV) By analyzing structure monosaccharide composition, molecular weight was determined be 115.5 KD, composed galacturonic acid...
It was initially found that neural-restrictive silencer factor/repressor 1-silencing transcription factor (REST) is a transcriptional repressor of neuronal genes in nonneuronal cells. However, it reported to be abundantly expressed various types aggressive cancer In this study, we evaluated the expression patterns REST renal cell carcinoma and its lower tumor tissues compared normal tissues. The chi-square test showed low closely related patients’ clinicopathologic parameters, including...
ABSTRACT Mycoplasma capricolum subsp. capripneumoniae is an important pathogen of goats that causes contagious caprine pleuropneumonia. Here, we report the complete genome sequence M. strain zly1309F, isolated from a Tibetan antelope ( Pantholops hodgsonii ) in China.
Plasmid-based reverse genetics has transformed influenza virus research by enabling the production of recombinant viruses from cloned cDNA copies viral genome segments. Reverse genetic requires cellular expression proteins polymerase basic 1, 2, acidic and nucleoprotein which collectively allow for transcription mRNA synthesis new negative-sense genomic RNA, thus all components needed to assemble infectious transfected cell lines. Given importance these in generation via genetics, we sought...
<title>Abstract</title> <bold>Background</bold> Influenza virus causes worldwide outbreaks and seasonal epidemics, severely threatening public health social development. Effective prevention therapy for influenza infections are a major challenge to global healthcare. <bold>Results</bold> Taurolidine effectively inhibited the proliferation of several human or animal strains protected mice from lethal-infection. treatment decreased viral titer in lungs infected mice, reduced immune cells...
Avian paramyxoviruses (APMV) belong to the subfamily Avulavirinae of family Paramyxoviridae and include 22 distinct subtypes or serotypes (1-22). paramyxovirus serotype 12 (APMV-12) is found sporadically in wild birds worldwide, reports from only Italy Taiwan have been published date; information on its genetic variation biological characteristics still limited. In this study, 3 APMV-12 strains, designated WB19, LY9, LY11, were isolated 8643 bird faecal samples during annual influenza virus...
Abstract M2 isoform of pyruvate kinase ( PKM2 ) plays an important role in reprogramming cell metabolism which is a hall-marker tumorigenesis. expression altering closely related to cancer and tumor growth. In the present study, we analyzed liver order clarify its potential application value diagnosis prognosis patients. cancerous tissues, was significantly higher than normal tissues. High expressing patient’s age, gender, histological type, grade, stage, T classification poor survival....