A5088188956- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Antibiotic Resistance in Bacteria
- Calcium signaling and nucleotide metabolism
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Plant Reproductive Biology
- Nitric Oxide and Endothelin Effects
- Cellular transport and secretion
- Hormonal and reproductive studies
- Ovarian function and disorders
- Nutrition and Health Studies
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Reproductive System and Pregnancy
- Nutrition, Genetics, and Disease
- Effects and risks of endocrine disrupting chemicals
- Neuropeptides and Animal Physiology
- Eicosanoids and Hypertension Pharmacology
- Developmental Biology and Gene Regulation
Autonomous University of Queretaro
2018-2025
Universidad Nacional Autónoma de México
2012-2020
Prostate cancer cells are responsive to adrenergic and thyroid stimuli. It is well established that β-adrenergic activation (protein kinase A [PKA]/cAMP response element binding protein [CREB]) promotes progression, but the role of hormones poorly understood. We analyzed effects stimulation (isoproterenol [ISO]) and/or hormone on neuroendocrine (NE) differentiation cell invasion, using in vivo (LNCaP tumor) vitro models DU145 human cells). Nude mice were inoculated with LNCaP treated for 6...
Bisphenol A (BPA) promotes colon cancer by altering the physiological functions of hormones. Quercetin (Q) can regulate signaling pathways through hormone receptors, inhibiting cells. The antiproliferative effects Q and its fermented extract (FEQ, obtained gastrointestinal digestion in vitro colonic fermentation) were analyzed HT-29 cells exposed to BPA. Polyphenols quantified FEQ HPLC their antioxidant capacity DPPH ORAC. 3,4-dihydroxyphenylacetic acid (DOPAC) FEQ. exhibited capacity. Cell...
ABSTRACT An epidemiology study of Klebsiella spp . causing infections was carried out. In the study, K. pneumoniae identified with a prevalence 94.6%, quasipneumoniae 3.8%, and variicola 1.6%. Here, we report draft genome sequence four selected species complex (KpSC) clinical isolates obtained from different sources.
Spermatozoa are male reproductive cells especially designed to reach, recognize and fuse with the egg. To perform these tasks, sperm must be prepared face a constantly changing environment overcome several physical barriers. Being in essence transcriptionally translationally silent, motile rely profoundly on diverse signaling mechanisms orient themselves swim directed fashion, contend challenging environmental conditions during their journey find In particular, Ca2+-mediated is pivotal for...
Catsper is a Ca 2+ permeable channel required for sperm hyperactivation. In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined. this work, we describe identification and characterization important regulatory elements murine gene proximal promoter. Four transcription start sites three functional Sox‐binding were identified Interestingly, factors Sox5 Sox9 caused significant increase transactivation promoter...
The mammalian oocyte extracellular matrix known as the zona pellucida (ZP) acts a barrier to accomplish sperm fusion with female gamete. Although penetration of ZP is limiting event achieve fertilization, this one least comprehended stages gamete interaction. Even though previous studies suggest that proteases origin contribute facilitate passage through ZP, in human process not yet fully understood. aim study was determine ability degrade recombinant (rhZPs) proteins and characterize...
Arachidonic acid (AA), a compound secreted by Sertoli cells (SC) in FSH-dependent manner, is able to induce the release of Ca2+ from internal stores round spermatids and pachytene spermatocytes. In this study, possible site(s) action AA spermatids, signalling pathways associated intracellular targeted AA-induced were pharmacologically characterized measuring using fluorescent probes. Our results suggest that acts interacting with fatty G protein coupled receptor, initiating cascade may...
Abstract Background The signaling pathways of the intracellular second messengers cAMP and Ca 2+ play a crucial role in numerous physiological processes human spermatozoa. One such process is acrosome reaction (AR), which necessary for spermatozoa to traverse egg envelope expose fusogenic membrane allowing egg–sperm fusion. Progesterone zona pellucida elicit an increase that needed AR mammalian This mediated by initial influx but also release from stores. It known stores central regulation...
Abstract Background Stress and elevated cortisol levels have negative effects on fertility, although there is controversy about the effect of human sperm. One study reported that hydrocortisone (HC), synthetic form cortisol, does not activate CatSper channel but able to inhibit its activation by progesterone (Pg). However, subsequent reports showed HC has an agonist CatSper, producing intracellular Ca 2+ ([Ca ] i ) increases. These studies were performed using only electrophysiological...
Thyroxine (T4) promotes cell proliferation and tumor growth in prostate cancer models, but it is unknown if the increase triiodothyronine (T3)/T4 ratio could attenuate development. We assessed T3 effects on thyroid response, histology, proliferation, apoptosis of wild-type (WT) TRAMP (transgenic adenocarcinoma mouse prostate) mice. Physiological doses were administered drinking water (2.5, 5 15 µg/100 g body weight) for 6 weeks. None modified weight or serum levels testosterone, all them...
Abstract Axonal projection is controlled by discrete regions localized at the neuroepithelium, guiding neurite growth during embryonic development. These exert their effect through expression of a family chemotropic molecules, which actively participate in formation neuronal connections central nervous system vertebrates. Previous studies describe prosomere 1 (P1) as possible organizer axonal rostral rhombencephalon, contributing to caudal reticulospinal rhombencephalic neurons. This work...
Spermatozoa are male reproductive cells especially designed to reach, recognize and fuse with the egg. To perform these tasks, sperm must be prepared face a constantly changing environment overcome several physical barriers. Being in essence transcriptionally translationally silent, motile rely profoundly on diverse signaling mechanisms orient themselves swim directed fashion, contend challenging environmental conditions during their journey find In particular, Ca2+-mediated is pivotal for...
Los disruptores endocrinos (EDC) son compuestos químicos exógenos de origen sintético o natural que interfieren en las funciones hormonales. Se estima más 1000 presentes el medio ambiente poseen una posible actividad disruptora. La exposición a EDC se ha relacionado con desarrollo múltiples enfermedades como la obesidad. obesógenos xenobióticos regulan y promueven inadecuadamente acumulación lípidos adipogénesis. adipogénesis es proceso mediante cual células progenitoras similares...