A5011274510- Thyroid Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Neonatal Health and Biochemistry
- Hormonal and reproductive studies
- Diet, Metabolism, and Disease
- Photodynamic Therapy Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Breast Cancer Treatment Studies
- Inflammatory mediators and NSAID effects
- Thyroid Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Bioactive Compounds and Antitumor Agents
- Cancer Immunotherapy and Biomarkers
- Heme Oxygenase-1 and Carbon Monoxide
- Neurogenesis and neuroplasticity mechanisms
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Pancreatic function and diabetes
- Veterinary Oncology Research
- Hydrogen's biological and therapeutic effects
- Antioxidant Activity and Oxidative Stress
- Neuroendocrine regulation and behavior
Universidad Nacional Autónoma de México
2016-2025
Instituto Mexicano de Oftalmología IAP
2012-2019
Prostate cancer cells are responsive to adrenergic and thyroid stimuli. It is well established that β-adrenergic activation (protein kinase A [PKA]/cAMP response element binding protein [CREB]) promotes progression, but the role of hormones poorly understood. We analyzed effects stimulation (isoproterenol [ISO]) and/or hormone on neuroendocrine (NE) differentiation cell invasion, using in vivo (LNCaP tumor) vitro models DU145 human cells). Nude mice were inoculated with LNCaP treated for 6...
Cancer stem cells (CSCs) are described as a subpopulation of with capabilities self-renewal, chemoresistance, and invasiveness. CSCs reside in tumor niches can be studied vitro through their enrichment spheroids (Stem). Molecular iodine (I2) induces apoptosis differentiation various cancer cells. I2 activate peroxisome proliferator-activated receptors type gamma (PPARγ), its pathways associated oxidant/antioxidant capacity. This work aimed to compare the effect supplementation progenitor CSC...
Mammary cancer has a high incidence in canines and is an excellent model of spontaneous carcinogenesis. Molecular iodine (I2) exerts antineoplastic effects on different cells activating re-differentiation pathways. In co-administration with anthracyclines, I2 impairs chemoresistance installation prevents the severity side generated by these drugs. This study random double-blind protocol that analyzes impact (10 mg/day) two administration schemes Doxorubicin (DOX; 30 mg/m2) 27 canine patients...
The immune system is a crucial component in cancer progression or regression. Molecular iodine (I2) exerts significant antineoplastic effects, acting as differentiation inductor and modulator, but its effects antitumor response are not elucidated. present work analyzed the effect of I2 human breast cell lines with low (MCF-7) high (MDA-MB231) metastatic potential under both vitro (cell proliferation invasion assay) vivo (xenografts athymic nude mice) conditions. In analysis showed that 200...
This study analyzes an oral supplement of molecular iodine (I2), alone and in combination with the neoadjuvant therapy 5-fluorouracil/epirubicin/cyclophosphamide or taxotere/epirubicin (FEC/TE) women Early (stage II) Advanced III) breast cancer. In group, 30 were treated I2 (5 mg/day) placebo (colored water) for 7–35 days before surgery. For patients received placebo, along FEC/TE treatment. After surgery, all + 170 days. supplementation showed a significant attenuation side effects absence...
Neuroblastoma (Nb), the most common extracranial tumor in children, exhibited remarkable phenotypic diversity and heterogeneous clinical behavior. Tumors with MYCN overexpression have a worse prognosis. promotes progression by inducing cell proliferation, de-differentiation, dysregulated mitochondrial metabolism. Cyclophosphamide (CFF) at minimum effective oral doses (metronomic therapy) exerts beneficial actions on chemoresistant cancers. Molecular iodine (I2) coadministration all-trans...
This study analyzes oral supplement of molecular iodine (I2) alone and in combination with the neoadjuvant therapy 5-fluorouracil/epirubicin/cyclophosphamide or taxotere/epirubicin (FEC/TE) women Early (stage II) Advanced III) breast cancer. In group, 30 were treated I2 (5 mg/day) placebo (colored water) for 7–35 days before surgery. For patients received along FEC/TE treatment. After surgery, all + 170 days. supplementation showed a significant attenuation side effects absence...
Molecular iodine (I2) induces apoptotic, antiangiogenic, and antiproliferative effects in breast cancer cells. Little is known about its on the tumor immune microenvironment. We studied effect of oral (5 mg/day) I2 supplementation alone or together with conventional chemotherapy (Cht+I2) component tumors from a previously published pilot study conducted Mexico. RNA-seq, Cht+I2 samples showed significant increases expression Th1 Th17 pathways. Tumor composition determined by deconvolution...
Pancreatitis has been implicated in the development and progression of type 2 diabetes cancer. The pancreas uptakes molecular iodine (I2), which anti-inflammatory antioxidant effects. present work analyzes whether oral I2 supplementation prevents pancreatic alterations promoted by low doses streptozotocin (STZ). CD1 mice (12 weeks old) were divided into following groups: control; STZ (20 mg/kg/day, i.p. for five days); (0.2 mg/Kg/day drinking water 15 combined (STZ + I2). Inflammation...
Neuroblastoma (NB) is the most common solid childhood tumor, and all-trans retinoic acid (ATRA) used as a treatment to decrease minimal residual disease. Molecular iodine (I 2 ) induces differentiation and/or apoptosis in several neoplastic cells through activation of PPARγ nuclear receptors. Here, we analyzed whether coadministration I ATRA increases efficacy NB treatment. ATRA-sensitive (SH-SY5Y), partially-sensitive (SK-N-BE(2)), non-sensitive (SK-N-AS) were analyze effect vitro...
Pancreatic alterations such as inflammation and insulin resistance accompany hypothyroidism. Molecular iodine (I2) exerts antioxidant differentiation actions in several tissues, the pancreas is an iodine-uptake tissue. We analyzed effect of two oral I2 doses on pancreatic disorders a model hypothyroidism for 30 days. Adult female rabbits were divided into following groups: control, moderate dose (0.2 mg/kg, M-I2), high (2.0 H-I2), methimazole (MMI; 10 mg/kg), MMI + M-I2,, H-I2. Moderate or...
Molecular iodine (I2) induces apoptotic, antiangiogenic, and antiproliferative effects in breast cancer cells. Little is known about its on the tumor immune microenvironment. We studied effect of oral (5 mg/day) I2 supplementation alone or together with conventional chemotherapy (Cht+I2) im-mune component tumors from a previously published pilot study conducted Mexico. RNA-seq, Cht+I2 samples showed significant increases expression Th1 Th17 pathways. Tumor composition determined by...
Thyronines are essential for the development of male reproductive system, including prostate gland. Metabolically active 3,5,3' triiodothyronine (T(3)) is generated mainly by extrathyroidal, enzymatic 5'deiodination prohormone thyroxine (T(4)), which catalyzed deiodinases type 1 (D1) and 2 (D2). Prostate D1 activity highly expressed during puberty declines with age, but continuous, long-term sexual prevents this reduction. The aims study were to characterize changes in prostatic response...
Thyroxine (T4) promotes cell proliferation and tumor growth in prostate cancer models, but it is unknown if the increase triiodothyronine (T3)/T4 ratio could attenuate development. We assessed T3 effects on thyroid response, histology, proliferation, apoptosis of wild-type (WT) TRAMP (transgenic adenocarcinoma mouse prostate) mice. Physiological doses were administered drinking water (2.5, 5 15 µg/100 g body weight) for 6 weeks. None modified weight or serum levels testosterone, all them...
Pancreatic alterations like inflammation and insulin resistance accompany hypothyroidism. Molecular iodine (I2) exerts antioxidant differentiation actions in several tissues, the pancreas is an iodine-uptake tissue. We analyzed effect of two oral I2 doses on pancreatic disorders a model hypothyroidism for 30 days. Adult female rabbits were divided into following groups: control, moderate dose (0.2 mg/kg, M-I2), high (2.0 H-I2), methimazole (MMI; 10 mg/kg), MMI+M-I2, MMI+H-I2. Moderate or...
Metronomic chemotherapy with cyclophosphamide (Cpp) has shown promising results in cancer protocols. These lower and prolonged doses have antiangiogenic, pro-cytotoxic, moderate secondary effects. Molecular iodine (I2) reduces the viability of cells and, chemotherapeutic agents, activates antitumoral immune response diminishes side The present work evaluates adjuvant oral I2 Cpp using a murine model mammary cancer. Female Sprague Dawley rats 7,12-dimethylbenzantracene-induced tumors received...
Abstract Neuroblastoma (NB) is one of childhood´s most common extra-cranial solid tumors, with 90 % the cases occurring in those <5 years age. NB highly heterogeneous, variable biological and clinical characteristics; it exhibits spontaneous or induced regression processes (low-risk NB) up to invasive capacities drug-resistance tumors (high-risk NB). High-risk overexpresses N-MYC gene associated invasion chemoresistance. On other hand, molecular iodine (I2) exerts antiproliferative...
Pancreatitis and insulitis are known causes of type 2 diabetes mellitus, recently it has been shown that hypothyroidism can exacerbate these alterations. Molecular iodine (I2) exerts antioxidant, anti-inflammatory, anti-dyslipidemia effects in diverse tissues. The objective this study was to evaluate the effect oral supplement halogen induction prediabetic status a model pharmacological hypothyroidism. Adult virgin rabbits Chinchilla breed were divided into control (n = 6) hypothyroid...