The treatment of breast cancer requires long chemotherapy management, which is accompanied by severe side effects. Localized delivery anticancer drugs helps to increase the drug concentration at site action and overcome such a problem. In present study, chitosan hydrogel was prepared for local 5-Fluorouracil. in vitro release behavior investigated activity evaluated against MCF-7 cells using MTT assay. vivo studies were via intra-tumoral injection 5-FU loaded into female rats. results...

Bio-nanotechnology employing bio-sourced nanomaterial is an emerging avenue serving the field of fish medicine. Marine-sourced chitosan nanoparticles (CSNPs) a well-known antimicrobial and immunomodulatory reagent with low or no harm side effects on their human consumers. In this study, in vitro skin mucus serum antibacterial activity assays along intestinal histology, histochemical, gene expression analyses were performed to evaluate impact dietary CSNPs (5 g kg−1 dry feed) rainbow trout...

Abstract Nannochloropsis oculata ( N. ) is a marine microalga containing bioactive compounds and high omega-3 polyunsaturated fatty acid (ω-3 PUFAs). Therefore, it very promising for nutraceutical the functional food industry applications. Three groups of Nile tilapia (forty-five fish/group) were fed on basal diets or 5% (N5) 10% (N10) seven weeks. Fish growth performance, proximate composition, lipid (fatty acids/ FAs lipoproteins) profile estimated. In addition, expression pattern some...

Abstract Nanotechnology is an emerging avenue employed in disease prevention and treatment. This study evaluated the antimicrobial efficacy of chitosan nanoparticles (CSNPs) against major bacterial oomycete fish pathogens comparison with suspension. Initially, minimum inhibitory concentrations (MIC, MIC 90 ) were determined per cent inhibition growth was calculated. Subsequently, bactericidal (MBCs) determined. The time‐dependent disruptions CSNP‐treated observed via transmission electron...

Abstract Background Feed supplements, including essential trace elements are believed to play an important role in augmenting fish immune response. In this context, selenium nanoparticles (SeNPs) diets via a green biosynthesis strategy have attracted considerable interest. investigation, (SeNPs, 79.26 nm) synthesized from the microalga Pediastrum boryanum were incorporated into Nile tilapia explore its beneficial effects on defense and intestinal integrity, comparison with control basal...

Marine bio-sourced chitosan nanoparticles (CSNP) are antimicrobial and immunomodulatory agents beneficial for fish medicine. Herein, dietary CSNP was investigated the amelioration of systemic inflammatory responses an induced model. One hundred forty-four rainbow trout were assigned to one pathogen-free non-supplemented group (negative control), three challenged groups: (positive CSNP-preventive, CSNP-therapeutic. After a feeding experiment extended 21 days, organosomatic indices (OSI)...

Bio-nanotechnology employing natural products is a promising approach for discovering and developing new drugs treating various diseases. Chitosan (CH) product produced from crustacean shells. Recently, both CH nanoparticles (CH-NP) have been used in pharmaceutical biomedical applications owing to their unique properties. The main aim of this study was determine the efficacy CH-NP reducing negative effects 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) albino rats. Twenty adult male rats were...

This study investigates the fabrication of algogenic zinc nanoparticles (ZnNPs), examining their biomimetic properties and potential antibacterial effectiveness against fish pathogens. The rising incidence antibiotic resistance in aquaculture demands innovative strategies for disease management, highlighting importance developing biocompatible effective antimicrobial agents. In this context, ZnNPs were synthesized using Pediastrum boryanum microalgal extract as reducing capping agent....

Abstract Maintaining a healthy intestine is essential for growth and host defense mechanisms of farmed fish, particularly those densely stocked. In this context, maintaining intestinal microbiota proper digestion, absorption, integrity the mucosa utmost importance. Nano‐form (SeNPs)‐enriched‐ Pediastrum boryanum (Turpin) exhibits antimicrobial, antioxidant, antitumor properties. Therefore, SeNPs are valuable nutritional supplements aquatic animals. Algogenic Se nanoparticles (SeNPs, 79.26...

Abstract Background Trace elements play a crucial role in fish nutrition, with zinc (Zn) being one of the most important elements. BIO-sourced nanoparticles were synthesized using green microalga Pediastrum boryanum (BIO-ZnNPs, 29.35 nm). 30 or 60 mg/ kg dry feed BIO-ZnNPs (BIO-ZnNPs and ) mixed Nile tilapia ( Oreochromis niloticus basal diet fed to for 8 weeks evaluate their impact on growth, digestion, intestinal integrity, antioxidative status, immunity. Results A significant enhancement...

Two field experiments were carried out to investigate effects of spraying organic acids and amino combinations between acid potassium citrate or under drought stress. The objectives these studies aimed the effect application on plant growth characters, yield components, leaf chemical constituents, enzyme activity as well seed quality fiber properties Giza 86 cotton cultivar. conducted at Sakha Agricultural Research station, during 2009 2010 seasons. Plant irrigation was regularly needs using...

Halophytes are plants that have significant economic importance with, the potential for use in therapeutic medicine and environmental restoration. This study compiles a comparison of chemical composition ethanol extracts from aquatic terrestrial halophyte (Halophila stipulacea, Halodule uninervis, Thalassodendron ciliatum Spergularia marina, Suaeda aegyptiaca Arthrocnemum fruticosum) using gas chromatography –Mass spectrometry (GC-MS) analysis also demonstrated antimicrobial properties....

Fish feed additives are recently encouraged to improve cultured fish health and production. Dietary supplementation with betaine (Bet) chromium picolinate (Cr-Pic) is known for its high quality the benefit of aquaculture. A total 180 healthy equal-sized O. niloticus were fed on a non-supplemented basal diet, or diet supplemented Bet (10g/kg dry feed) (Bet group) Cr-Pic (800 μg/kg (Cr-Pic their combination at same dosing regimens + 6 weeks feeding trial. Our findings revealed that dietary...

Abstract The current study evaluated the potential ameliorative effect of a dietary immune modulator, Nannochloropsis oculata microalga, on mercuric chloride (HgCl 2 )-induced toxicity Nile tilapia. tilapia (45–50 g) were fed control diet or exposed to ¼ LC 50 HgCl (0.3 mg/L) and medicated feed supplemented with N. (5% 10% (50 100 g/kg dry feed)) for 21 days. Growth somatic indices, Hg 2+ bioaccumulation in muscles, serum acetylcholinesterase (AChE) activity investigated. Antioxidant...

It is unclear how fish in freshwater ecosystems are affected by the combined presence of microplastics (MPs) and anionic surfactant detergents. So, our investigations focus on nephrotoxic effects both Polyethylene (PE-MPs) Sodium lauryl sulfate (SLS) single or exposure African Catfish (Clarias gariepinus). In current study, rearing water catfish gariepinus) was supplied with 0, 10 mg/L PE-MPs, 4 SLS, their combination for 15 days. Blood analysis kidney functions histological appraisals renal...

Chitosan (CH) is a natural product produced from the shells of crustaceans.Both CH and nanoparticles (CH-NPs) have recently been used in various pharmaceutical biomedical applications.The present study aimed to evaluate potency chitosan or reducing negative effects 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)induced haematotoxicity nephrotoxicity albino rats.Methods: Twenty adult male rats were placed four groups five each: control group, TCDD group (10µg/kg intraperitoneally injected), +...