A5060420175- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
- Cardiovascular and exercise physiology
- Chronic Myeloid Leukemia Treatments
- Coenzyme Q10 studies and effects
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Vitamin D Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Pancreatic function and diabetes
- Genetic Neurodegenerative Diseases
- PARP inhibition in cancer therapy
- Vitamin C and Antioxidants Research
- Vitamin K Research Studies
- Cardiovascular Effects of Exercise
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Physical Activity and Health
- Peripheral Neuropathies and Disorders
Wageningen University & Research
2019-2024
Radboud University Medical Center
2016-2020
Radboud University Nijmegen
2016-2020
Radboud Institute for Molecular Life Sciences
2019
Maastricht University
2006-2017
University Medical Center
2013-2014
École Polytechnique Fédérale de Lausanne
2014
Maastricht University Medical Centre
2012-2014
TiFN
2008-2013
Food & Nutrition
2012
Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular (IMCL) exceeds intracellular needs and induces lipotoxic events, ultimately contributing to the development of insulin resistance. Lipid droplet (LD)-coating proteins may control proper Perilipin (PLIN2/adipose differentiation-related protein [ADRP]) one most abundantly expressed LD-coating Here we examined role PLIN2 myocellular handling sensitivity investigating effects vitro...
OBJECTIVE To determine whether resveratrol supplementation can improve insulin sensitivity and promote overall metabolic health on top of standard diabetes care. RESEARCH DESIGN AND METHODS Seventeen subjects with well-controlled type 2 (T2D) were treated placebo 150 mg/day (resVida) in a randomized double-blind crossover study for 30 days. The main outcome measure was by the hyperinsulinemic-euglycemic clamp technique. RESULTS Hepatic peripheral not affected treatment. Intrahepatic lipid...
Abstract Background An inadequate protein intake may offset the muscle synthetic response after physical activity, reducing possible benefits of an active lifestyle for mass. We examined effects 12 weeks daily supplementation on lean body mass, strength, and performance in physically older adults with a low habitual (<1.0 g/kg/day). Methods A randomized double‐blinded controlled trial was performed among 116 [age 69 (interquartile range: 67–73) years, 82% male] who were training 4 day...
A low fat oxidative capacity has been linked to muscle diacylglycerol (DAG) accumulation and insulin resistance. Alternatively, a oxidation rate may stimulate glucose oxidation, thereby enhancing disposal. Here, we investigated whether an ethyl-2-[6-(4-chlorophenoxy)hexyl]-oxirane-2-carboxylate (etomoxir)-induced inhibition of leads storage An intervention in healthy male subjects was combined with studies human primary myotubes. Furthermore, DAG triacylglycerol (TAG), mitochondrial...
Resveratrol, a natural polyphenolic compound produced by various plants (e.g. red grapes) and found in wine, has glucose-lowering effects humans rodent models of obesity and/or diabetes. The mechanisms behind these have been suggested to include resveratrol-induced secretion the gut incretin hormone glucagon-like peptide-1. We investigated postprandial glucagon responses obese human subjects before after 30 days resveratrol supplementation.Postprandial plasma hormones peptide-1...
Statin myopathy is linked to disturbances in mitochondrial function and exercise intolerance. To determine whether differences exist performance, muscle function, oxidative capacity content between symptomatic asymptomatic statin users, control subjects. Cross-sectional study. Department of Physiology, Radboud University Medical Center. Long-term subjects (n = 10 per group). Maximal incremental cycling tests, involuntary electrically stimulated isometric quadriceps-muscle contractions,...
Background The involvement of muscle triacylglycerol (TAG) storage in the onset insulin resistance is questioned and attention has shifted towards inhibition signalling by lipid intermediate diacylglycerol (DAG). enzyme 1,2-acylCoA:diacylglyceroltransferase-1 (DGAT1) esterifies a fatty acyl-CoA on DAG to form TAG. Therefore, aim present study was investigate if unilateral overexpression DGAT1 adult rat Tibialis anterior (TA) will increase conversion into TAG, thereby improving sensitivity....
Abstract Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in been implicated metabolic disease development, it remains unknown whether muscle altered human models type 2 diabetes. Here we used primary myotubes (HPM) to investigate if clock- gene expression donors with obesity or diabetes compared metabolically healthy donors. HPM were obtained from skeletal biopsies four groups: diabetic patients their...
Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity. Recently, it has been suggested that α lipoic acid (ALA) improves sensitivity by lowering nonadipose tissues via activation of skeletal AMP-activated protein kinase (AMPK). We examined whether chronic ALA supplementation prevents muscular lipid high-fat diets AMPK. In addition, we tested if was able to improve rats fed low- and (LFD, HFD). Supplementing male Wistar 0.5% for 8 weeks significantly...
In conditions of continuous high-fat (HF) intake, the degree saturation fatty acids (FAs) in diet might have a crucial role onset obesity and its metabolic complications. particular, FA composition influence storage form lipids inside skeletal muscle. The aim present study was to examine whether HF diets differentially affects weight gain accumulation myocellular triacylglycerol (TAG) diacylglycerol (DAG). Furthermore, we examined reflected lipid intermediates.C57Bl6 mice were fed (45%...
Vitamin D deficiencies are common in elderly, which increases the risk for, e.g., bone fractures. Identification of determinants vitamin status may provide leads for specific deficiency prevention strategies. Although have been studied various populations, this has not examined elderly that a physically active lifestyle. 450 who do use supplements was determined and information on possible (demographic, dietary intake physical activity) collected around prolonged four day walking event July...