Jeffrey Guo
A5086055110- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Social and Cultural Dynamics
- Adipokines, Inflammation, and Metabolic Diseases
- Social Capital and Networks
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Sex and Gender in Healthcare
- HIV Research and Treatment
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Genomics and Chromatin Dynamics
- Innovation and Knowledge Management
- interferon and immune responses
- Menopause: Health Impacts and Treatments
- Lipid metabolism and biosynthesis
- COVID-19 Clinical Research Studies
- Bioinformatics and Genomic Networks
- Estrogen and related hormone effects
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Texas A&M University
2023
Gladstone Institutes
2020
University of California, San Francisco
2020
Quantitative BioSciences
2020
University of California, Berkeley
2017
The Ohio State University
2017
National Taiwan University
2012
A newly described coronavirus named severe acute respiratory syndrome 2 (SARS-CoV-2), which is the causative agent of disease 2019 (COVID-19), has infected over 2.3 million people, led to death more than 160,000 individuals and caused worldwide social economic disruption1,2. There are no antiviral drugs with proven clinical efficacy for treatment COVID-19, nor there any vaccines that prevent infection SARS-CoV-2, efforts develop hampered by limited knowledge molecular details how SARS-CoV-2...
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 closely related more lethal but less transmissible coronaviruses SARS-CoV-1 Middle East (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on...
ABSTRACT An outbreak of the novel coronavirus SARS-CoV-2, causative agent COVID-19 respiratory disease, has infected over 290,000 people since end 2019, killed 12,000, and caused worldwide social economic disruption 1,2 . There are currently no antiviral drugs with proven efficacy nor there vaccines for its prevention. Unfortunately, scientific community little knowledge molecular details SARS-CoV-2 infection. To illuminate this, we cloned, tagged expressed 26 29 viral proteins in human...
Epigenetic modifications play a crucial role in gene regulation and have been implicated various physiological processes disease conditions. DNA methylation (DNAm) has the etiology progression of many stress-related psychiatric behaviors such as depression. The ability to manipulate DNAm may provide means reverse treat disorders. Although CRISPR-based technologies enabled locus-specific editing, their clinical applicability be limited due immunogenicity concerns off-target effects. In this...
Purpose – The purpose of this paper is to explore the multi‐dimensions social capital and relationships among individuals, groups, firms, establishing perspective relations for competition strategies implementation.
Epigenomic annotations for the rat lag far behind those of human and mouse, despite rat's immense utility in pharmacological behavioral studies need to understand their epigenetic mechanisms. We have designed a targeted-enrichment method followed by next-generation sequencing (Methyl-Seq) identify DNA methylation (DNAm) signatures across genome. The design reflected an attempt create more comprehensive investigation epigenome, as it included promoters, CpG islands, island shores all RefSeq...
Abstract Lipid metabolism reprogramming is a novel feature of malignancies. Identifying the vulnerability lipid alteration in tumor cells provides new window to treat cancer. Here, we unraveled that glioblastoma (GBM) patients containing high levels droplets (LDs), special organelles storing cholesterol esters and triglycerides cells, presented poor survival. We found LDs largely formed tissues from GBM patients, but rarely low grade gliomas normal brain tissues, demonstrating might serve as...
Neuroblastoma (NB) is a malignant tumor that accounts for ~15% of all pediatric cancer mortality. Nearly half patients present with high-risk disease has poor outcome, and the proto-oncogene MYCN amplified in 45% cases. Further, relapsed neuroblastoma demonstrates frequent activation mitogen activated protein kinase (MAPK) signaling, including mutations suppressor NF1 epigenetic silencing gene. Human induced pluripotent stem cells (iPSCs) represent valuable tool by which to further dissect...