A5100385956- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Meningioma and schwannoma management
- Herpesvirus Infections and Treatments
- Hepatitis C virus research
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Studies
- Virology and Viral Diseases
- Parvovirus B19 Infection Studies
- Facial Trauma and Fracture Management
- Ion channel regulation and function
- DNA Repair Mechanisms
- Bacteriophages and microbial interactions
- COVID-19 Pandemic Impacts
- Ophthalmology and Visual Impairment Studies
- Socioeconomic and Demographic Analysis
- Antibiotic Use and Resistance
- Carbon and Quantum Dots Applications
- Medical and Agricultural Research Studies
- Influenza Virus Research Studies
- Protein purification and stability
- Viral gastroenteritis research and epidemiology
- Venomous Animal Envenomation and Studies
- Corneal surgery and disorders
East China Normal University
2025
Peking University
2016-2024
Anhui Medical University
2024
Hainan Normal University
2023
Shaanxi University of Science and Technology
2022
First Hospital of Jilin University
2021
Jilin University
2021
Lanzhou University
2021
Tianjin First Center Hospital
2020
Tianjin Medical University
2020
Purpose.: Myopia is an important cause of correctable visual impairment worldwide. Genetic and environmental factors contribute to its development. The population Chinese university students consists approximately 30 million young people characterized by academic excellence similar ages. To date, little known about their refractive status. Our study designed investigate the prevalence myopia in this specific population. Methods.: This a cross-sectional among Shanghai, China; 5083 from...
Sepsis is a subtype of systemic inflammatory response syndrome (SIRS), which characterized by infection. Circulating microRNAs (miRNAs), including miR-150, miR-146a and miR-223, are potential biomarkers sepsis. In this study, we demonstrated that measuring the relative expression miR-146a/U6 in plasma, using 2-ΔΔCt method, provides method for differentiating between sepsis non-sepsis-SIRS. We observed significant increase initial cohort 6 non-sepsis-SIRS patients compared to 4 (P=0.01)...
The effect of antibiotics on horizontal gene transfer (HGT) is controversial, and the underlying mechanism remains poorly understood. Here, using Escherichia coli SM10λπ as donor strain, which carries a chromosomally integrated RP4 plasmid, we investigated conjugational mobilizable gentamicin (Gm) resistance plasmid. results showed that an exposure to restricted survival recipient cells significantly enhanced SM10λπ-Pseudomonas aeruginosa PAO1 conjugation, was attenuated by deficiency...
Autophagy is an essential degradation and recycling process that maintains cellular homeostasis during stress or nutrient deprivation. However, certain types of tumors such as pancreatic cancers can circumvent autophagy inhibition to sustain growth. The mechanism autophagy-deficient ductal adenocarcinoma (PDAC) uses grow under deprivation poorly understood. Our data show in PDAC results UDP-glucose dehydrogenase (UGDH) degradation, which dependent on autophagic cargo receptor sequestosome 1...
Although Beclin 1 and mTOR are considered to be the main molecules modulate autophagic process, searching for other autophagy-regulating is still an ongoing challenge scientists. Here we demonstrated that FoxO1, a forkhead O family protein, mediator of autophagy. Upon oxidative stress or serum starvation, endogenous FoxO1 was required autophagy in human cancer cell lines, this process independent FoxO1's transcriptional activity as well 1. In response stress, dissociated from...
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report function for p62 base excision repair that is distinct from its known functions. Loss impairs capacity and increases the sensitivity cancer cells alkylating oxidizing agents. In alkylative oxidative damage, accumulated nucleus,acetylated by hMOF,and deacetylated SIRT7, acetylated recruited chromatin. The chromatin-enriched directly interacts with APE1, key enzyme BER pathway,...
Mitochondria are involved in various biological processes including intracellular homeostasis, proliferation, senescence, and death, mitochondrial mitophagy is closely related to the development regression of malignant tumors. Recent studies confirmed that hypoglycemic drug metformin (Met) exerted antitumor effects, protected neural cells, improved immunity, while arsenic trioxide (ATO) an effective chemotherapeutic agent for clinical treatment leukemia solid However, possible combined...
Abstract Varicella-zoster virus (VZV) is a highly contagious agent of varicella and herpes zoster. Varicella can be lethal to immunocompromised patients, babies, HIV patients other adults with impaired immunity. Serological evaluation immunity VZV will help determine which individuals are susceptible evaluate vaccine effectiveness. A collection 110 monoclonal antibodies (mAbs) were obtained by immunization mice membrane proteins or cell-free virus. The mAbs well characterized competitive...
Abstract Fourteen serum samples obtained from hepatitis B virus (HBV) chronic carriers and patients recovered infection were used with four sodium dodecyl sulfate‐treated enzyme‐linked immunosorbent assay (ELISA) plates available commercially, one self‐prepared HBcAg analog for evaluation of anti‐HBe subclass pattern absorbance. The had the best performance thus 104 (60 male 44 female) HBV 439 (247 192 individuals. Tests aspartate aminotransferase (AST) alanine (ALT) also carried out in 21...
Sublethally irradiated mice were administered with scorpion venom peptides (SVP) or PBS in the saline control group, 3 days before and 7 consecutive after irradiation. Hematopoietic recovery was assessed by bone marrow (BM) cell proliferation index (PI) colony forming unit-granulocyte/macrophage (CFU-GM), spleen weight (SI) thymus (TI), colony-forming unit-spleen (CFU-S) peripheral leukocyte counts. In addition, IL-1α SCF levels BM, IL-6 GM-CSF serum determined. SVP treated groups, PI...
A polarity-dependent two-photon fluorescent probe for evaluation of autophagy in the process diabetic mouse skin ulcer-induced inflammation was constructed.
Influenza A viruses, especially H3N2 and H1N1 subtypes, are viruses that often spread among humans cause influenza pandemic. There have been several big pandemics caused millions of human deaths in history, the threat to public health is still serious nowadays due frequent antigenic drift shift events. However, only few effective anti-flu drugs developed date. The high development cost, long research time, drug side effects major bottlenecks, which could be relieved by repositioning. In this...
Background Multicenter laboratory may apply both automated flow cytometer and microscopy for urinalysis. Automated such as Sysmex UF‐1000i evaluates particles with native urine without centrifugation reports “counts per μL.” Microscopic examination recommended the reference method sediment analysis results HPF (or μL).” Moreover, some from are needed to be checked visually under microscopy. Therefore, it is worth establish consistency of these two methods. Methods Urine specimens 412...
The rapid increase of syphilis underscores a tremendous need to carefully evaluate many new serological tests for and choose efficient economical strategies screening, especially in the case primary infection with low antibody titer. Between 2011 2012, 73 patients' sera samples were included this retrospective study. They either TRUST or TPPA reactive, LA (latex agglutination) based auto3 TP CLIA (chemiluminescence assay) Architect Syphilis assay reactive. contradictory weak response further...