Abstract There are numerous types of orbital tumors, among which ameloblastoma is a rare metastatic benign tumor that often originates in the jaw and later metastasizes to orbit. The mystery it lies that, although classified as tumor, exhibits high recurrence malignant potential with invasiveness, posing serious threat ocular health quality life patients. prognosis relatively poor, but there still hope. With aggressive treatment close follow-up observation, patients may have possibility...

Purpose: The purpose of this paper was to investigate the expression and function Ubiquitin-conjugating enzyme 2T (UBE2T), a human E2 ubiquitin-conjugating enzyme, in retinoblastoma. Methods: UBE2T normal retina retinoblastoma analyzed using Gene Expression Omnibus (GEO) databases, its immunohistochemically evaluated 29 sections 5 retinas. Then CCK-8, flow cytometry, RNA-sequencing analysis, vivo assays were performed explore exact role Results: We found that showed higher than GEO datasets...

To evaluate the ophthalmic manifestations and radiographic features of ectopic orbital meningioma to improve diagnostic accuracy. Patient data from patients admitted our institution during a 217-month period August 1999 September 2017 were included. manifestations, (CT MRI), diagnosis, pathology, therapeutic regimens, prognosis retrospectively reviewed. Six with identified. The mean age at first visit was 33.2 years (range, 7–56 years). All six displayed exophthalmos, upper eyelid oedema,...

Purpose Chemoresistance remains the primary obstacle threatening prognosis of retinoblastoma (RB). microRNAs (miRNAs) are acknowledged as critical regulators drug resistance. This study explored molecular mechanism miR-130a-3p affecting chemosensitivity RB to vincristine (VCR).Methods expression human retinal astrocytes and cell lines (Y79, WERI-Rb-1, SO-Rb50, SO-Rb70) was detected using RT-qPCR. VCR-resistant line Y79/VCR induced. its corresponding parental detected. cells were subjected...

Uveal melanoma (UM) is the most frequent primary eye cancer in adults with a 50% mortality rate. Characterizing fundamental signaling pathways that drive UM of importance for development targeted therapy. This study aims to probe impact sclerostin (SOST) on malignant progression and regulation Wnt/β-catenin signaling.Epithelial-type (n=20) spindle-type (n=16) tissues were collected immunohistochemical staining SOST, Wnt-1, β-catenin expressions. SOST was silenced three cell lines (primary...

To delineate the development of interepicanthal fold distance (IEFD) to interpupillary (IPD) in Chinese children, and quantify how their ratio (EFDPD ratio) affects parent's judgment on whether a child's two eyes appear misaligned.The values IPD IEFD were measured 750 aged between 3 17 years. The developmental trend EFDPD was established. Two hundred parents shown series pictures children with varying ratios asked judge child each picture demonstrated misaligned eyes. Based responses,...

Uveal melanoma (UM) is the most common intraocular malignancy in adults. The prognosis poor once metastasis has developed. treatment of metastatic UM remains challenging nowadays due to lacking a deep understanding biological characteristics this disease. Here, we revealed cell subpopulations with distinct functional status and existence cells high invasive potential within heterogeneous primary UM. single-cell sequencing data were retrieved from GSE139829 GSE138433, through which identified...

Retinoblastoma (RB) is the most common intraocular malignancy in children. It has been previously reported that p38 MAPK related to pathogenesis of RB. Here we aim at investigating how affected RB progression through mediating USP22/SIRT1/SOST axis. In this study, Thirty-two cases and normal retinal tissues were collected. The expression MAPK, phosphorylation (P-p38 MAPK), USP22, SIRT1 SOST clinical cells was measured using RT-qPCR, IHC assay or western blot analysis. Cell proliferation...

Abstract Purpose Chemoresistance remains the primary obstacle threatening prognosis of retinoblastoma (RB). microRNAs (miRNAs) are acknowledged as critical regulator drug resistance. This study explored molecular mechanism miR-130a-3p affecting chemosensitivity RB to vincristine (VCR). Methods expression VCR-sensitive and VCR-resistant tissues was detected using RT-qPCR. cell line Y79/VCR induced. its corresponding parental detected. cells were subjected overexpression treatment. The...

The aim of this study was to explore the immune protective mechanism rMOMP protein vaccine in intraocular hypertension and retinal optic nerve injury rats.The ophthalmic prepared quality-controlled.Sixty normal adult SD rats were randomly divided into two groups establish a chronic ocular model an model.The vaccinated with rMOMP-CS vaccine.Fluorogold retrograde tracing used observe ganglion cells, immunofluorescence method determine expression GAP43, CD3, BDNF, GDNF.rMOMP met requirements...

ObJective To study the hemodynamic characteristics of ophthalmic artery and central retinal in patients with thyroid-associated ophthalmopathy (TAO),and to analyze relevance between blood flow parameters clinical characteristics.At last,discuss different influence factors on supply TAO.Methods Use U.S.company GE's Logic7 Color Doppler Ultrasound diagnostic apparatus,to detect 49 TAO cases (90 eyes) whose thyroid function was normal or stable over six months 24 controls (48...

Objective To observe the safety and clinical curative effect of trabeculectomy on continuous high intraocular pressure in primary angle closure glaucoma.Methods A retrospective analysis 33 cases (33 eyes) (IOP≥40mmHg) patients with performed (treatment group),37 (37 (IOP＜40mmHg) underwent (control group),were compared between two groups preoperative postoperative visual acuity,intraocular pressure,filtering bleb anterior chamber formation condition.Results No choroidal fulminant...

Objective To investigate the imaging and pathological characteristics of choroidal melanoma.Methods The data from 26 patients with melanoma were analyzed retrospectively by means ultrasonography,CT Scan,MRI pathology.Results Early symptoms closely associated tumor location.The examination B-ultrasonography,color Doppler,CT MRI showed chomidal improved accuracy in diagnosis.At early stage.choroidal must be differentiated hemorrhage metastatic carcinma.Orbital exenteration was done 3 cases...

Background Glaucoma associates with apoptosis of retinal ganglion cells ( RGCs).Research showed that ciliary neurotrophic factor (CNTF) can repair optic nerve trauma,but it has not reported whether CNTF a protective effect on glaucomatous neuropathy. Objective This experimental study was to explore the RGCs in rat eyes acute ocular hypertension. Methods Ocular hypertension models were induced bilateral 24 clean Wistar rats by forced perfusion balanced salt solution into anterior chamber.Two...

Objective To analyze the surgical characteristics and skills of various orbital tumors,so to improve rate success,and reduce complications. Methods A total 112 cases (2-75 years old,an average 30.1 years; male:70 cases,female:42 cases) lesions were analyzed,including 26 cavernous hemangioma,17 schwannomas,14 inflammatory pseudotumor,11 dermoid cyst,10 pleomorphic adenoma lacrimal glan,9 lymphoma,8venous angioma,7 adenoidcysticcarcinom,4 osteom,3 vascular tumors,and 3 meningioma. Results The...

Objective To analyze the hemodynamic characteristics of orbital cavernous hemangioma (OCH)by dynamic enhanced CT scanning and to reveal hemodyanmie features OCH.Method It was a retrospective case series study.21 cases with OCH presenting Tianjin Eye Hospital from Apr,2006 Dec, 2007 were analyzed retrospectively.They all detected seanning.AU 21 diagnostic determined by histopathology after operation.We took plain position,shape,density tumor relationship between surrounding tissues then we...