A5066058736- Fungal and yeast genetics research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Contact Dermatitis and Allergies
- Chronic Myeloid Leukemia Treatments
- Porphyrin Metabolism and Disorders
- Plant Stress Responses and Tolerance
- Polysaccharides and Plant Cell Walls
- Legume Nitrogen Fixing Symbiosis
- Allergic Rhinitis and Sensitization
- Platelet Disorders and Treatments
- Plant and fungal interactions
- Urticaria and Related Conditions
- Photosynthetic Processes and Mechanisms
- Fermentation and Sensory Analysis
- Plant Reproductive Biology
- Bacterial Genetics and Biotechnology
Behringwerke (Germany)
2021-2023
Philipps University of Marburg
2015-2020
Microorganisms have evolved specific cell surface molecules that enable discrimination between cells from the same and a different kind. Here, we investigate role of Flo11-type adhesins social yeasts in kin discrimination. We measure adhesion forces mediated by Flo11A-type domains using single-cell force spectroscopy, quantify Flo11A-based aggregation populations determine Flo11A-dependent segregation competing yeast strains biofilms. find Flo11A diverse species confer remarkably strong...
Siderophores play an essential role in a multitude of microbial iron acquisition pathways. Many bacteria use xenosiderophores as sources that are produced by different species their habitat. We investigated the capacity xenosiderophore uptake soil bacterium Bacillus subtilis and found it employs several substrate binding proteins with high specificities affinities for ferric siderophore species. Protein–ligand interaction studies revealed dissociation constants low nanomolar range, while...
There is an emerging concept that in addition to circulating coagulation factor IX (FIX), extravascular FIX contributes hemostasis. Our objective was evaluate the efficacy of using animal models tail clip bleeding and ferric chloride-induced thrombosis. Mutant rFIX proteins with described enhanced (rFIXK5R) or reduced (rFIXK5A) binding extracellular matrix were generated characterized vitro aPTT, one-stage clotting, modified FX assays. Using hemophilia B mice, pharmacokinetic (PK) parameters...