A5089123207- Microtubule and mitosis dynamics
- Malaria Research and Control
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Prion Diseases and Protein Misfolding
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
- Respiratory viral infections research
- Nuclear Structure and Function
- Virus-based gene therapy research
- Biological Research and Disease Studies
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Research on Leishmaniasis Studies
- Plant Virus Research Studies
- HIV Research and Treatment
Heidelberg University
2019-2023
University Hospital Heidelberg
2019-2023
German Center for Infection Research
2023
Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV). Another candidate that currently garners increasing attention is human bocavirus 1 (HBoV1). Notably, HBoV1 capsids can cross-package recombinant (r)AAV2 genomes, yielding rAAV2/HBoV1 chimeras specifically transduce polarized airway epithelia (pHAEs). Here, we largely expanded repertoire rAAV/BoV chimeras, assembling...
Malaria-causing parasites achieve rapid proliferation in human blood through multiple rounds of asynchronous nuclear division followed by daughter cell formation. Nuclear divisions critically depend on the centriolar plaque, which organizes intranuclear spindle microtubules. The plaque consists an extranuclear compartment, is connected via a pore-like structure to chromatin-free compartment. Composition and function this non-canonical centrosome remain largely elusive. Centrins, reside part,...
Abstract Rapid proliferation of Plasmodium falciparum parasites in human red blood cells is the cause malaria and underpinned by an unconventional cell division mode, called schizogony. Contrary to model organisms, P. replicates multiple rounds closed asynchronous nuclear divisions that are not interrupted cytokinesis. Organization dynamics critical factors are, however, poorly understood. Centriolar plaques, centrosomes , important regulators serve as microtubule organizing centers. Early...
Centrins are small calcium-binding proteins that have a variety of roles and universally associated with eukaryotic centrosomes. Rapid proliferation the malaria-causing parasite Plasmodium falciparum in human blood depends on particularly divergent acentriolar centrosome, which incorporates several essential centrins. Their precise mode action, however, remains unclear. In this study calcium-inducible liquid-liquid phase separation is revealed as an evolutionarily conserved principle...
Novel tick-borne phleboviruses in the Phenuiviridae family, which are highly pathogenic humans and all closely related to Uukuniemi virus (UUKV), have recently emerged on different continents. How assemble, bud, exit cells remains largely elusive. Here, we performed high-resolution, label-free mass spectrometry analysis of UUKV immunoprecipitated from cell lysates identified 39 cellular partners interacting with viral envelope glycoproteins. The importance these host factors for infection...
Abstract Rapid proliferation of the malaria-causing parasite Plasmodium falciparum in human blood depends on a particularly divergent and acentriolar centrosome, which incorporates several essential centrins. Centrins are small calcium-binding proteins that have variety roles universally associated with eukaryotic centrosomes. Their precise mode action, however, remains unclear. In this study calcium-inducible liquid-liquid phase separation is revealed as an evolutionary conserved principle...
Abstract Malaria-causing parasites achieve rapid proliferation in human blood through multiple rounds of asynchronous nuclear division followed by daughter cell formation. Nuclear divisions critically depend on the centriolar plaque, which organizes intranuclear spindle microtubules. The plaque consists an extranuclear compartment, is connected via a pore-like structure to chromatin-free compartment. Composition and function this non-canonical centrosome remain largely elusive. Centrins,...