A5033485883- Immune cells in cancer
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Mobile Agent-Based Network Management
- Periodontal Regeneration and Treatments
- Immune responses and vaccinations
- Oral microbiology and periodontitis research
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Evacuation and Crowd Dynamics
- Medical Imaging and Pathology Studies
- Neurosurgical Procedures and Complications
- Genetic and Kidney Cyst Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biomarkers in Disease Mechanisms
- Oral and gingival health research
- Collaboration in agile enterprises
- Hemodynamic Monitoring and Therapy
- RNA modifications and cancer
- Bone and Dental Protein Studies
- Maternal and fetal healthcare
- Tea Polyphenols and Effects
- Time Series Analysis and Forecasting
- Ferroptosis and cancer prognosis
- Tuberous Sclerosis Complex Research
Daiichi Sankyo (United States)
2025
Tongji Hospital
2022-2023
Huazhong University of Science and Technology
2022-2023
Cangzhou Central Hospital
2023
XinHua Hospital
2021-2022
Shanghai Jiao Tong University
2005-2022
King's College London
2020-2022
Shanghai Ninth People's Hospital
2022
China-Japan Friendship Hospital
2020-2022
STMicroelectronics (United Kingdom)
2020-2021
Loss of tissue attachment as a consequence bacterial infection and inflammation represents the main therapeutic target for treatment periodontitis. Cementoblasts, cells that produce mineralized tissue, cementum, is responsible connecting soft periodontal to tooth, are key cell type maintaining/restoring following disease. Here, we identify two distinct stem populations contribute cementoblast differentiation at different times. During postnatal development, cementoblasts formed from...
Telocytes (TCs) or interstitial cells are characterised in vivo by their long projections that contact other cell types. Although telocytes can be found many different tissues including the heart, lung, and intestine, tissue-specific roles poorly understood. Here we identify a specific signalling role for periodontium whereby regulate macrophage activity. We performed scRNA-seq lineage tracing to macrophages mouse homeostasis periodontitis carried out hepatocyte growth factor (HGF)...
Abstract Background: ILD, an important safety risk of T-DXd across various cancer indications, requires regular monitoring in patients (pts) receiving T-DXd. Diagnosing ILD is complex and physiological, clinical, radiologic assessments, mechanisms driving onset are not well understood. We performed longitudinal proteomics analysis serum samples to identify early diagnostic biomarkers characterize biological associated with T-DXd-related ILD. Methods: The SomaScan™ Olink platforms were used...
This paper proposes a novel method to locate crowd behavior instability spatio-temporally using velocity-field based social force model. Considering the impacts of velocity field on interaction between individuals, we establish an improved model by introducing collision probability in view distribution. As compared with commonly- used model, which defines as dependent variable relative geometric (physical) position this can provide better prediction interactions dynamic crowd. With...
Periodontal disease, a chronic inflammation induced by bacteria, is closely linked with diabetes mellitus. Many complications associated are related to epigenetic changes. However, the exact changes whereby affects periodontal disease remain largely unknown. Thus, we sought investigate role of diabetes-dependent gingival tissue in susceptibility disease.We studied effect streptozotocin-induced minipigs on morphological and Accordingly, randomly divided six into two groups: group, n = 3;...
In Brief INTRODUCTION: Elevated concentrations of isovaleric (IVA), methylmalonic (MMA), and propionic acid are associated with impaired consciousness in genetic diseases (organic acidemias). We conjectured that part the central nervous system depression observed these disorders was due to anesthetic effects metabolites. tested three hypotheses. First, metabolites would have anesthetic-sparing effects, possibly being anesthetics by themselves. Second, compounds modulate glycine...
Gastric cancer (GC) is a prevalent malignancy in the digestive system that poses serious threat to human health. Anti-silencing function 1B (ASF1B) performs an important role progression of numerous tumors; however, its GC still requires further elucidation. Using data from The Cancer Genome Atlas, expression levels ASF1B tissues were analyzed and survival curve for high-ASF1B low-ASF1B groups was plotted using Kaplan-Meier method. Reverse transcription-quantitative PCR performed evaluate...
Streptococcus agalactiae [also known as group B (GBS)] is a tremendous threat to young infants. Eighty pediatric GBS infection cases were enrolled from teaching hospital in Shanghai between 2009 and 2020; among them, 72.5% (58/80) diagnosed with bloodstream (BSI). Sequence types (STs) serotypes of associated strains identified, most the Ib/clonal complex (CC)12 (86.7%, 13/15) caused BSIs, which was significantly higher than that genetically related clone Ib/CC10 (20%, 2/10; p < 0.05)....
The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance mesenteric microvascular function were explored in a rat model hemorrhagic shock (HS). Following controlled hemorrhage, rats infused with equal volumes either pPolyHb, hetastarch (HES), or red blood cell (RBC). results showed that pPolyHb was superior to HES RBC restoring reversing anaerobic metabolism. We observed reduction the diameter microvasculature after HS. Resuscitation able restore...
In this paper, the technology of auxiliary VLAN is discussed. When IP phones are connected to existing switch-based campus area network, data traffic and voice present on at same time. To avoid a significant reduction quality VoIP traffic, separated from an VLAN. PBX, there three frame types in which transmit switch. typical network with dynamic port VLANs, added. The VMPS server client, used for configured respectively; moreover, configuration ports belong implemented detail. Auxiliary can...
BackgroundOur goal was to develop a risk stratification index (RSI) that could guide management of our patients. We hypothesized the risks unexpected overstay admission (OS) and emergency department (ED) transfer are predictable on basis patient factors for elective outpatient shoulder arthroscopic surgery.MethodsWe first identified 124,860 subjects who received surgery in Healthcare Cost Utilization Project database. next conducted multivariable regression analysis identify associated with...
Abstract Background Telocytes (TCs) or interstitial cells are characterised in vivo by their long projections that contact other cell types. Although telocytes can be found many different tissues luding the heart 1 , lung 2 and intestine 3 tissue-specific roles poorly understood. Here we identify a signalling role for periodontium whereby regulate macrophage activity. Methods We performed scRNA-seq lineage tracing to TCs mouse homeostasis periodontitis carried out HGF inhibition experiments...
The periodontal ligament (PDL) is an essential tissue connecting teeth and bone. It a complex specifically designed to absorb the forces of mastication; analysis its multiple cell populations important understand function changes associated with disease. Cells in are not fully understood due their physical location small size. challenging isolate thin layers cells compared many other more substantial tissues. Here, we provide straightforward protocol for isolation from mice.
Abstract Background The clinical significance of group B streptococcus (GBS) was different among clonal complexes (CCs), accurate strain typing GBS would facilitate prognostic evaluation, epidemiological investigation and infection control. aim this study to construct a practical facile CCs prediction model for S. agalactiae . Methods A total 325 non-duplicated strains were collected from samples in Xinhua Hospital, Shanghai, China. Multilocus sequence (MLST) method used molecular...
In this paper, we improved the traditional FF (floor Field) model by using theory of cellular automata on personnel evacuation simulation redefining static and dynamic field strength adding guide in model. The extended analyzed different impact directional guiding mode behavior after an imaginary supermarket, analysis situation shows a better result.
In order to achieve the ease of use and performance requirements network teaching system, a solution based on open source framework Spring, Hibernate JavaServer Faces (JSF) is proposed. The generics DAO schema introduced into data persistence layer rich UI components development ICEfaces open-source Ajax are embedded in presentation meet need system. practice shows that improved method presented by this paper enables architecture provide high reusability, expansibility maintainability,...
Objective To investigate the related factors of nosocomial infection after severe thoracic trauma so as to provide basis and interventions for lowering rate. Methods A retrospective case series study was conducted in 148 cases surgically treated from January 2014 2016. There were 98 males 50 females with an average age 34.7 years. The abbreviated injury scale (AIS) ≥ 3 points. incidence statistically analyzed. possible analyzed, including age, gender, previous basic diseases, coma,...