A5032814587- Vascular Anomalies and Treatments
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Tracheal and airway disorders
- Cerebrovascular and genetic disorders
Anhui University
2025
University of San Francisco
2024
University of California, San Francisco
2022-2024
A novel fumigation moxibustion device has been designed to enable adjustable and controllable moxa smoke temperature, maintaining a relatively stable temperature while improving the utilization efficiency of smoke. The consists five main components: control chamber, outlet, measurement module, filtration elastic band. It is compact, refined, easy operate. allows users set desired according therapeutic needs simultaneously filters eliminates residual after treatment. This design addresses...
Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4* EC ), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular is a primary effect Notch4* , as isolated pial arteries from asymptomatic exhibited reduced pressure-induced arterial ex vivo. The nitric oxide (NO) synthase (NOS) inhibitor NG-nitro- l -arginine (L-NNA) corrected defects both...
Upregulation of Notch signaling is associated with brain arteriovenous malformation (bAVM), a disease that lacks pharmacological treatments. Tetracycline (tet)-regulatable endothelial expression constitutively active Notch4 (Notch4*tetEC) from birth induced bAVMs in 100% mice by P16. To test whether targeting downstream signaling, while sustaining the causal Notch4*tetEC expression, induces AVM normalization, we deleted Rbpj, mediator endothelium P16, combining tet-repressible...
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder with manifestations including severe nose bleeding and microhemorrhage in brains. Despite being the second most common inherited disorder, pathophysiological mechanism underlying HHT-associated hemorrhage poorly understood. HHT pathogenesis thought to follow a Knudsonian two-hit model, requiring somatic mutation for lesion formation. Mutations activin receptor-like kinase 1 ( ALK1 ) gene cause type 2. We...