Minimal change disease (MCD) is a podocytopathy more commonly seen in children, but it also accounts for 10%-25% of adult nephrotic syndrome. High-dose oral glucocorticoids were recommended initial treatment MCD. However, long-term use systemic corticosteroids associated with significant adverse events, such as steroid-induced diabetes and infections. The aim this study was to investigate the clinical efficacy safety half-dose combined rituximab (RTX) We recruited 74 patients MCD confirmed...

Enantioselective 7-exo-trig cyclocarbopalladation-initiated carbonylation cascade reactions, leading to seven-membered dibenzo[b,d]azepin-6-ones containing a thermodynamically controlled stereogenic axis, have been realized for the first time. A series of 7-acetate- or 7-acetamide-substituted are obtained under atmospheric pressure CO in good yields with excellent diastereo- and enantioselectivities. The calculated energy difference between diastereoisomers generated from biaryl axis center...

Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years Zhanjiang, Guangdong province, China. This study the first time to investigate its chemical composition antiviral activity. On dry weight basis, this was constituted ca. 35.18% ash, 11.20% protein, 1.06% lipid 47.73% total carbohydrate, main carbohydrate water-soluble polysaccharide. The protein analysis indicated presence essential amino acids, which accounted 36.35% protein. most abundant...

Cembrane-type diterpenoids are a large and structurally varied group of natural products isolated from both terrestrial marine organisms. The present paper reviews all the metabolites cembrane diterpenes, reported up to 2010. discussed in this review can be divided into several different structural families featuring variety ring sizes oxidation patterns. currently known biological activities will presented as well. Keywords: Diterpenoid, Cembrane, Natural product, Biological activity

A palladium-catalyzed imidoylative cycloamidation of N-alkyl-2-isocyanobenzamides with 2,6-disubstituted aryl iodides, affording unprecedented axially chiral 2-arylquinazolinones, has been developed good yields and atroposelectivities. In this coupling–cyclization process, the biaryl linkage heteroaromatic ring are formed sequentially in one step. When N-(2,4-dimethoxyphenyl)-2-isocyanobenzamide is applied as a substrate, 2,3-diarylquinazolinones containing two stereogenic axes produced...

A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at depth of 1300 m. The designated as F00120, identified member the genus Penicillium on basis morphology and ITS sequence analysis. One sesquiterpene quinone, named penicilliumin (1), along with two known compounds ergosterol (2) peroxide (3), were purified cultures F00120 by silica gel column, Sephadex LH-20 preparative thin layer chromatography. Their...

Open AccessCCS ChemistryCOMMUNICATION5 Sep 2022A New Saddle-Shaped Aza Analog of Tetraphenylene: Atroposelective Synthesis and Application as a Chiral Acylating Reagent Yu Luo, Sidi Cheng, Yan Peng, Xilong Wang, Jing Li, Chunfang Gan, Shuang Luo Qiang Zhu State Key Laboratory Respiratory Disease, Guangzhou Institutes Biomedicine Health, Chinese Academy Sciences, 510530 University Shijingshan District, Beijing 100049 , Cheng Peng Wang Li Gan Guangxi Natural Polymer Chemistry Physics, College...

A chiral phosphoric acid-catalyzed thio-Michael addition/enantioselective protonation has been developed for the first time. The reaction applies 7-methylene-6-aryl-7H-dibenzo[b,d]azepines, products of Pd-catalyzed imidoylative Heck cyclization, as Michael acceptors in reactions with a wide range aryl thiols. Diversified 7-[(arylthio)methyl]-7H-dibenzo[b,d]azepines bearing benzylic stereocenter and thermodynamically regulated biaryl axis were produced good to excellent enantioselectivity...

Sargassaceae, the most abundant family in Fucales, was recently formed through merging of two former families Sargassaceae and Cystoseiraceae. It is widely distributed world’s oceans, notably tropical coastal regions, with exception coasts Antarctica South America. Numerous bioactivities have been discovered investigations chemical diversity family. The secondary metabolites unique structures found this classified as terpenoids, phlorotannins, steroids, among others. These compounds...

A new C

A new polyhydroxy sterol ester, (25S)-5alpha-cholestane-3beta,6alpha,7alpha,8,15alpha,16beta-hexahydroxyl-26-O-14'Z-eicosenoate (1), together with seven known steroid derivatives (2-8), were isolated from the EtOH extract of whole body China Sea starfish Asterina pectinifera. The structure 1 was determined by using extensive spectra analysis (IR, 1D and 2D NMR, MS), chemical degradation, comparison compound (25S)-5alpha-cholestane-3beta,6alpha,7alpha,8,15alpha,16beta,26-heptol (2). All...

Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on basis extensive spectroscopic analyses and by comparison their spectral data those related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity NF-κB activation using cell-based HEK293 luciferase reporter gene assay.

Abstract A cataluminescence (CTL) sensor using Y 2 O 3 nanoparticles as the sensing materials was proposed for determination of ethyl acetate. This acetate showed high sensitivity and specificity at optimal temperature 264°C. Quantitative analysis performed a wavelength 425 nm. The linear ranges CTL intensity vs concentrations were 2.0–250 ppm ( r = 0.9965) 250–6500 0.9997) with detection limit (3σ) 0.5 ppm. There no response or weak when foreign substances such formic acid, n ‐hexane,...

Background: SHR8554 is a novel μ-opioid receptor-biased agonist. It has analgesic effects by selectively activating the G protein-coupled pathway. Additionally, it can weakly activate ß-arrestin-2 pathway, resulting in limited number of side effects, such as gastrointestinal inhibition. Previous studies have shown that good safety and tolerability, but pharmacokinetic characteristics humans not been reported. This study was designed to investigate pharmacokinetics healthy Chinese male...

Further chemical investigation on the marine sponge Callyspongia sp. collected from South China Sea led to isolation of a new diketopiperazine, named callysponine A (1), as well four known diketopiperazines, namely cyclo-(Gly-Pro) (2), cyclo-(Thr-Pro) (3), cyclo-(Ile-Pro) (4) and cyclo-(Pro-Pro) (5). The structure was determined basis NMR MS analysis, absolute stereochemistry defined by analysis coupling constants optical rotation. structures compounds were identified comparing their...

A palladium-catalyzed domino process for the quick assembly of tricyclic-fused heterocycles starting from aryl iodides and functionalized isocyanides containing a disubstituted terminal alkene has been developed. The is triggered by intermolecular isocyanide insertion, followed Heck-type carbopalladation intramolecular moiety subsequent C(sp2)–H activation. Moreover, an asymmetric version this reaction could also be realized in good yield with moderate enantioselectivity after preliminary...

A new (1) and two known (2 3) acylated taurine derivatives were isolated from the South China Sea marine sponge Axinella sp. The structures of compounds determined on basis spectral analysis. Compounds 1–3 did not inhibit growth hepatoma carcinoma cell (HepG2), lung (A549), human breast (MCF-7), no-small cancer (NCI-H460) nasopharyngeal lines.