A5082342572- Hormonal and reproductive studies
- Reproductive Biology and Fertility
- Muscle metabolism and nutrition
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Pharmacological Effects and Assays
- Metabolomics and Mass Spectrometry Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Stress Responses and Cortisol
- Lung Cancer Diagnosis and Treatment
- Proteins in Food Systems
- Ovarian function and disorders
- Social and Educational Sciences
- Cancer, Lipids, and Metabolism
- Biofuel production and bioconversion
- Glioma Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- RNA modifications and cancer
- Spinal Cord Injury Research
- Workplace Health and Well-being
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Cardiac Health and Mental Health
- Advanced Proteomics Techniques and Applications
- Asthma and respiratory diseases
Lund University
2015-2025
Skåne University Hospital
2016-2022
Is it possible to identify by mass spectrometry a wider range of proteins and key involved in folliculogenesis oocyte growth development studying follicular fluid (FF) from human small antral follicles (hSAF)?The largest number currently reported FF was identified this study analysing hSAF where several showed strong relationship with developmental processes.Protein composition ovarian constitutes the microenvironment for development. Previous proteomics studies have analysed fluids...
Background: Prostate cancer therapy with surgical or chemical castration GnRH agonists has been linked to elevated FSH levels, which may contribute secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for beyond the reproductive system, its metabolic impact remains unclear difficult disentangle from that of androgens. In this study, we examined changes induced by distinguished them those caused testosterone. Methods: Plasma samples...
To evaluate the effects of a cognitive behavioural training programme and physical activity for patients with stress-related illnesses.In randomized controlled study, were allocated randomly to 1 3 groups, where group participated in programme, 2 3, control group, was offered usual care course study.A total 75 study. They had been on sick leave at least 50% time between month years due illnesses.Measurements autonomic activity, pressure-pain thresholds subjective ratings health behaviour...
Abstract Background Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD currently the third leading cause of death worldwide. Far more than 15 % smokers get COPD: fact, most develop some amount impairment. Smoking‐related associated with both acute exacerbations and closely correlated to comorbidities, such as cardiovascular lung cancer. The objective our study (KOL‐Örestad) identify biomarkers ex‐smokers, early signs COPD,...
Glioblastoma (GBM), the most malignant of primary brain tumors, is a devastating and deadly disease, with median survival 14 months from diagnosis, despite standard regimens radical tumor surgery, maximal safe radiation, concomitant chemotherapy. GBM tumors nearly always re-emerge after initial treatment frequently display resistance to current treatments. One theory that may explain re-emergence existence glioma stemlike cells (GSCs). We sought identify variant protein features expressed in...
Testosterone is a hormone that plays key role in carbohydrate, fat, and protein metabolism. deficiency associated with multiple comorbidities, e.g., metabolic syndrome type 2 diabetes. Despite its importance many pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated short-term changes of pharmacologically induced castration and, subsequently, testosterone supplementation healthy young males. Thirty subjects were submitted to...
Testosterone deficiency in males is associated with serious comorbidities such as cardiovascular disease, diabetes type two, and also an increased risk of premature death. The pathogenetic mechanism behind this association, however, has not yet been clarified potentially bidirectional. aim clinical trial was to gain insight into the short-term effect changes testosterone on blood analytes healthy young men. Thirty male volunteers were recruited monitored our designed human model. Blood...
Plasma analysis by mass spectrometry-based proteomics remains a challenge due to its large dynamic range of 10 orders in magnitude. We created methodology for protein identification known as Wise MS Transfer (WiMT). Melanoma plasma samples from biobank archives were directly analyzed using simple sample preparation. WiMT is based on MS1 features between several runs together with custom databases ID generation. This entails multi-level database different immunodepletion strategies applying...
Background: Reliable biomarkers of androgen activity in humans are lacking. The aim this study was, therefore, to identify new protein markers biological and test their predictive value relation low vs normal testosterone values some deficiency linked pathologies. Methods: Blood samples from 30 healthy GnRH antagonist treated males were collected at three time points: (1) before administration; (2) 3 weeks later, just undecanoate injection, (3) after additional 2 weeks. Subsequently, they...
Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation metabolic disease. The association seems to have a bidirectional nature not well understood. present study aims investigate the early unidirectional induced T changes by measuring fasting amino acid (AA) levels in human model, which short-term alterations were induced. We designed model 30 healthy young males pharmacologically changes, resulted three time points for blood collection:...
Abstract Background Reliable biomarkers ofv androgen activity in humans are lacking. The aim of this study was, therefore, to identify new protein markers biological and test their predictive value relation low vs. normal testosterone values some deficiency linked pathologies. Methods Blood samples from 30 healthy GnRH-antagonist treated males were collected at three time points: a) before GnRH antagonist administration; b) 3 weeks later, just undecanoate injection, c) after additional 2...
ABSTRACT Testosterone is a hormone that plays key role in carbohydrate, fat, and protein metabolism. deficiency associated with multiple comorbidities, e.g ., metabolic syndrome type 2 diabetes. Despite its importance many pathways, the mechanisms by which it controls metabolism are not fully understood. The present study investigated short-term changes of pharmacologically induced castration testosterone supplementation healthy young males. Thirty subjects were submitted to depletion (TD)...
Polycystic ovaries (PCO) contain antral follicles that arrest growing around 3-11 mm in diameter, perturbing the dominant follicle's selection and subsequent ovulatory process. Proteomic alterations of PCO follicular fluid (FF) (i.e., microenvironment which oocyte develops until ovulation) have been studied from large connection with pickup during ovarian stimulation. The present study aimed to detect proteomic FF unstimulated human small (hSAF) obtained PCO. After performing deep-sequencing...