A5101944003- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Advanced Neuroimaging Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Genetic Associations and Epidemiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- T-cell and Retrovirus Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Stroke Rehabilitation and Recovery
- Autoimmune and Inflammatory Disorders Research
- Prion Diseases and Protein Misfolding
- Immune Cell Function and Interaction
- Telemedicine and Telehealth Implementation
- Effects of Vibration on Health
- Peripheral Neuropathies and Disorders
- Bioinformatics and Genomic Networks
- Cerebrospinal fluid and hydrocephalus
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
General University Hospital in Prague
2020-2025
Charles University
2014-2025
Abstract Multiple sclerosis is a leading cause of neurological disability in adults. Heterogeneity multiple clinical presentation has posed major challenge for identifying genetic variants associated with disease outcomes. To overcome this challenge, we used prospectively ascertained outcomes data from the largest international registry, MSBase. We assembled cohort deeply phenotyped individuals European ancestry relapse-onset sclerosis. unbiased genome-wide association study and machine...
Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, we describe actual trends multiple (MS) beginning their first disease‑modifying (DMTs) 2013 2021. The secondary objective was present history, collection, and scientific potential National MS registry (ReMuS).
Secondary progressive MS is associated with a worse prognosis, warranting the need for early predictive tools. The DAAE score estimates five-year risk of transition to clinical diagnosis SPMS, showing 38 % in high-risk patients Amsterdam and Buffalo data. remains be validated against objective disease progression criteria. External validation using data from Prague cohort MSBase-Lorscheider Among 2022 database, 14.3 clinically progressed according MSbase-Lorscheider criteria over five years....
<h3>BACKGROUND AND PURPOSE:</h3> Disappearance of T2 lesions into CSF spaces is frequently observed in patients with MS. Our aim was to investigate temporal changes cumulative atrophied brain lesion volume and 10-year confirmed disability progression. <h3>MATERIALS METHODS:</h3> We studied 176 relapsing-remitting MS who underwent MR imaging at baseline, 6 months, then yearly for 10 years. Occurrence new/enlarging lesions, volume, whole-brain, cortical ventricle volumes were assessed between...
Background . Neuromyelitis optica (NMO) and multiple sclerosis (MS) are often presenting with overlapping symptoms. The aim of this study was to determine whether how NMO MS differ regarding cerebral iron deposits in deep gray matter (DGM) the correlation between deposition clinical severity as well regional atrophy DGM. Methods We analyzed 20 patients NMO, 40 a relapsing-remitting (RR) form MS, healthy controls 1.5T MRI. Quantitative susceptibility mapping (QSM) performed estimate...
Abstract Multiple sclerosis (MS) is a leading cause of neurological disability in adults. Heterogeneity MS clinical presentation has posed major challenge for identifying genetic variants associated with disease outcomes. To overcome this challenge, we used prospectively ascertained outcomes data from the largest international Registry, MSBase. We assembled cohort deeply phenotyped individuals relapse-onset MS. unbiased genome-wide association study and machine learning approaches to assess...
The translational potential of MR-based connectivity modelling is limited by the need for advanced diffusion imaging, which not part clinical protocols many diseases. In addition, where data available, brain analyses rely on tractography algorithms imply two major limitations. First, tracking are known to be sensitive presence white matter lesions and therefore leading interpretation pitfalls poor inter-subject comparability in applications such as multiple sclerosis. Second, quality highly...
ABSTRACT BACKGROUND AND PURPOSE A high variability of brain MRI volume change measurement renders challenging its interpretation in multiple sclerosis (MS). Occurrence and clinical relevance observed apparent increase (BVI) MS patients have not been investigated yet. The objective was to quantify the prevalence factors associated with BVI. METHODS We examined 366 (2,317 scans) 44 controls (132 scans). Volumetric analysis changes performed by SIENA ScanView. BVI defined as >0%. compared...
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, mainly affecting young adults. Factors positively influencing its course include early antiinflammatory treatment and other comorbidities. The most common comorbidities occurring in MS patients with higher frequency than general population are neurological, psychiatric, cardiovascular, metabolic autoimmune. Just as comorbidity compensation affects MS, some cases, decompensation associated worse diseases....
Background: The aim of our pilot study was to assess the feasibility and effectiveness individual balance telerehabilitation for people with multiple sclerosis (MS). Methods: In this 20 individuals MS impairment were included (10 in experimental, 10 control group). experimental group underwent 12 weeks (with direct synchronous contact between physiotherapist patient). received conventional outpatient physiotherapy. standardized tests functional mobility assessed at baseline after...
Abstract The translational potential of MR-based connectivity modelling is limited by the need for advanced diffusion imaging, which not part clinical protocols many diseases. In addition, where data available, brain analyses rely on tractography algorithms imply two major limitations. First, tracking are known to be sensitive presence white matter lesions and therefore leading interpretation pitfalls poor inter-subject comparability in applications such as multiple sclerosis. Second,...