Background: Pressure-volume (PV) loops provide a wealth of information on cardiac function but are not readily available in clinical routine or trials. This study aimed to develop and validate noninvasive method compute individualized left ventricular PV loops. Methods: The proposed is based time-varying elastance, with experimentally optimized model parameters from training set (n=5 pigs), yielding Model inputs volume curves cardiovascular magnetic resonance imaging brachial pressure. was...

Background: Left ventricular outflow tract obstruction complicates hypertrophic cardiomyopathy and transcatheter mitral valve replacement. Septal reduction therapies including surgical myectomy alcohol septal ablation are limited by morbidity or coronary anatomy high pacemaker rates, respectively. We developed a novel procedure, mimicking myotomy, called Scoring Along the Midline Endocardium (SESAME). Methods: SESAME was performed in 5 naive pigs with percutaneous aortic banding–induced left...

Atrioventricular plane displacement (AVPD) is an indicator for systolic and diastolic function accounts 60% of the left ventricular, 80% right ventricular stroke volume. AVPD commonly measured clinically in echocardiography as mitral tricuspid annular excursion (MAPSE TAPSE), but has not been applied widely cardiovascular magnetic resonance (CMR). To date, there no robust automatic algorithm available that allows to be CMR with input a single timeframe. This study aimed develop, validate...

Left ventricular (LV) contractility and compliance are derived from pressure-volume (PV) loops during dynamic preload reduction, but reliable simultaneous measurements of pressure volume challenging with current technologies. We have developed a method to quantify PV reduction using real-time cardiovascular magnetic resonance (CMR) invasive LV pressures CMR-specific signal conditioning.

Pathological extravascular lung water is a facet of decompensated congestive heart failure that current cardiovascular magnetic resonance (CMR) methods fail to quantify. CMR can measure total density, but cannot distinguish between intravascular and fluid, thus not diagnostic. Therefore, we develop evaluate novel method by distinguishing from extracellular fluid compartments using two different contrast agents, gadolinium-chelates iron-based ferumoxytol. We created porcine models pulmonary...

Non-invasive quantification of pressure-volume (PV) loops from brachial pressure and cardiovascular magnetic resonance is a validated method but its application has been limited to resting heart rates. The aim this study was improve the previous validate it against invasive left-ventricular measurements in an experimental porcine model, further apply 16 healthy humans at rest during dobutamine stress. In addition, improved calculates arterial elastance which provides computation ratio...

MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element placed within the walls of beating left ventricle and shortened to narrow chamber dimensions. uses 2 new techniques: controlled intramyocardial guidewire navigation EDEN (Electrocardiographic Radial Depth Navigation). caused sustained reduction in dimensions healthy swine. Midventricular implants approximated papillary muscles. shortening improved...

Atrial fibrosis can be estimated noninvasively by magnetic resonance imaging (MRI) using late gadolinium enhancement (LGE), but diastolic dysfunction is clinically assessed transthoracic echocardiography (TTE), and rarely MRI. This study aimed to evaluate well-established parameters MRI, validate them with TTE left ventricular (LV) filling pressures, the relationship between atrial (LA) remodeling of function. The retrospectively included 105 patients (53 ± 16 years, 39 females) who...

Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range cardiovascular conditions, such as fibrillation, stroke, diastolic dysfunction. LA segmentations currently being performed manually, time-consuming observer-dependent.

Quantitative assessment of dynamic lung water accumulation is interest to unmask latent heart failure. We develop and validate a free-breathing 3D ultrashort echo time (UTE) sequence with automated inline image processing changes in density (LWD) using high-performance 0.55 T cardiovascular magnetic resonance (CMR). CMR was performed on 15 healthy subjects stack-of-spirals proton weighted UTE at T. Inline reconstruction the Gadgetron framework. A gravity-induced redistribution LWD provoked...

Mitral annular plane systolic excursion (MAPSE) and left ventricular (LV) early diastolic velocity (e') are key metrics of function, but not often measured by cardiovascular magnetic resonance (CMR). Its derivation is possible with manual, precise annotation the mitral valve (MV) insertion points along cardiac cycle in both two four-chamber long-axis cines, this process highly time-consuming, laborious, prone to errors. A fully automated, consistent, fast, accurate method for MV tracking...

Background Oxygen-enhanced magnetic resonance imaging (OE-MRI) can be used to assess regional lung function without ionizing radiation. Inhaled oxygen acts as a T1-shortening contrast agent increase signal in T1-weighted (T1w) images. However, proton density from pulmonary hyperoxic vasodilation may also contribute the measured enhancement. Our aim was quantify relative contributions of and vasodilatory effects enhancement OE-MRI both swine healthy volunteers. Methods We imaged 14...

Purpose Exercise‐induced dyspnea caused by lung water is an early heart failure symptom. Dynamic quantification during exercise therefore of interest to detect stage disease. This study developed a time‐resolved 3D MRI method quantify transient dynamics rest and stress. Methods The was evaluated in 15 healthy subjects 2 patients with imaged transitions between exercise, porcine model dynamic extravascular accumulation through mitral regurgitation ( n = 5). Time‐resolved images were acquired...

Summary Sixty percent of stroke volume ( SV ) is generated by atrioventricular plane displacement AVPD in a healthy left ventricle LV ). The aims were to determine the effect ST ‐elevation myocardial infarction STEMI on and contribution study relationship between infarct size IS location. Patients from CHILL ‐ MI MITOCARE studies with cardiovascular magnetic resonance within week n = 177, 59 ± 11 years) controls 20, 62 included. Left ventricular volumes quantified short‐axis images. was...

Pressure-volume (PV) loops have utility in the evaluation of cardiac pathophysiology but require invasive measurements. Recently, a time-varying elastance model to derive PV non-invasively was proposed, using left ventricular (LV) volume by cardiovascular magnetic resonance (CMR) and brachial cuff pressure as inputs. Validation performed CMR measurements acquired on same day, not simultaneously, without varying pre-loads. This study validates non-invasive used estimate at pre-loads, compared...

Abstract Purpose Tricuspid valve flow velocities are challenging to measure with cardiovascular MR, as the rapidly moving valvular plane prohibits direct evaluation, but they vitally important diastolic function evaluation. We developed an automated valve‐tracking 2D method for measuring through dynamic tricuspid valve. Methods Nine healthy subjects and 2 patients were imaged. The approach uses a previously trained deep learning network, TVnet, automatically track from long‐axis cine images....

Motivation: Quantification of lung water during exercise is interest for early diagnosis heart failure. Goal(s): To develop a time-resolved 3D MRI method to quantify in transitions between rest and exercise. Approach: We derive quantitative density (LWD) maps using motion corrected sliding-window image reconstruction. included 12 healthy controls 2 patients with failure, porcine model mitral regurgitation (n=5). Results: measured peak ΔLWD=16±6.8% controls, but detected...

Background In mitral valve dysfunction, noninvasive measurement of transmitral blood flow is an important clinical examination. Flow imaging the valve, however, challenging, since it moves in and out image plane during cardiac cycle. Purpose To more accurately measure flow, a slice‐following MRI phase contrast sequence proposed. This study aimed to implement such sequence, validate its functionality phantom healthy subjects, test feasibility patients with dysfunction. Study Type Prospective....

Atrioventricular plane displacement (AVPD) reflects longitudinal left ventricular (LV) systolic function, and wall thickening (WT) regional radial LV function. The temporal evolution of these measures after STEMI with CMR has not been evaluated. We aimed to investigate how AVPD WT are affected globally regionally from the sub-acute chronic phase ST-elevation myocardial infarction (STEMI).Healthy volunteers without cardiovascular disease medication (controls, n = 20) patients CHILL-MI study (...

Abstract To investigate if left and right atrioventricular plane displacement (AVPD) or regional contributions to SV are prognostic for outcome in patients with pulmonary arterial hypertension (PAH). Seventy-one PAH 20 sex- age-matched healthy controls underwent CMR. Myocardial borders RV insertion points were defined at end diastole systole cine short-axis stacks compute biventricular volumes, lateral (SV lat% ) septal sept% contribution stroke volume. Eight 2-, 3- 4-chamber long-axis views...

Left ventricular (LV) stroke work (SW) is calculated from the pressure-volume (PV) loop. PV loops do not contain information on longitudinal and radial pumping, leaving their contributions to SW unknown. A conceptual framework proposed derive SW, using force-length reflecting pumping. The aim of this study was develop validate experimentally explore these in healthy controls heart failure patients. Thirteen swine underwent cardiovascular magnetic resonance (CMR) LV pressure catheterization...

Patients with tetralogy of Fallot (TOF) may undergo pulmonary valve replacement (PVR) after initial full repair. We investigated indices biventricular function, work and efficiency TOF patients' using noninvasive pressure-volume (PV) loop analysis on cardiovascular magnetic resonance (CMR) images compared pre-and post PVR groups. Biventricular segmentations steady state free precession CMR were performed custom validated software (Segment version 2.0 R7067). Brachial cuff pressure estimated...