A5071004844- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Folate and B Vitamins Research
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Cell death mechanisms and regulation
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Treatments and Studies
- Aortic aneurysm repair treatments
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Advanced Fluorescence Microscopy Techniques
- Cancer Treatment and Pharmacology
- Oral and Maxillofacial Pathology
- MicroRNA in disease regulation
- Transgenic Plants and Applications
- Cancer-related gene regulation
- Venous Thromboembolism Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
Heidelberg University
2006-2024
University Hospital Heidelberg
2006-2024
University Medical Centre Mannheim
2006-2024
Klinikum Frankfurt Höchst
2014-2019
University Hospital Frankfurt
2013-2017
Goethe University Frankfurt
2013-2017
European Molecular Biology Laboratory
2007-2009
Zero to Three
2009
In-Q-Tel
2007
Enhancing nanoparticles’ anti-cancer capabilities as drug carriers requires the careful adjustment of formulation parameters, including loading efficiency, drug/carrier ratio, and synthesis method. Small adjustments to these parameters can significantly influence drug-loading efficiency nanoparticles. Our study explored how chitosan polyethylene glycol (PEG) coatings affect structural properties, efficacy Fe3O4 nanoparticles (NPs). The NPs was determined using FTIR spectrometry XRD. quantity...
Abstract We investigated the therapeutic efficiency of sulfonate‐modified polyvinyl alcohol beads loaded with doxorubicin, irinotecan or mitoxantrone in vitro and vivo a model experimental peritoneal carcinomatosis (PC). In , cell proliferation was efficiently impaired by doxorubicin drug eluting bead (DEB) treatment while DEBs were less effective than. Irinotecan showed little effect for both free drug. Apoptosis not different between DEB form more apoptosis induction observed cells...
During cancer therapy with DNA-damaging drug-agents, the development of secondary resistance to apoptosis can be observed. In search for novel therapeutic approaches that used in these cases, we monitored chemotherapy-induced a syngenic mouse tumor model. For this, murine colorectal carcinoma cells, which stably expressed FRET-based caspase-3 activity sensor, were introduced into animals induce peritoneal carcinomatosis or disseminated hepatic metastases. This system allowed vitro, vivo and...
INTRODUCTION:In recent years, many different methods were introduced for generation of 3D cell culture.However, currently available three-dimensional techniques are not suitable certain lines and sometimes showed a lack reproducibility.Therefore, specific protocols needed.In this work, we demonstrate generating culture SCC4 tongue cancer line discuss their applicability.MATERIALS AND METHODS: Using three methods, tumor spheroids generated from cells cultured 20 days.To investigate the...
Biliary tract cancers (BTCs) have a poor prognosis. BTCs are characterized by prominent desmoplastic reaction which possibly contributes to the aggressive phenotype of this tumor. The includes excessive production and deposition extracellular matrix proteins such as periostin, secreted protein acidic rich in cysteine (SPARC), thrombospondin-1, well accumulation α-smooth muscle actin-positive cancer-associated fibroblasts immune cells, secreting growth factors cytokines including transforming...
The principal aim of the current study was to investigate relationship between miR-149 T>C (rs2292832) and miR-196a2 C>T (rs11614913) small non-coding RNA polymorphisms risk developing CRC in Azerbaijani population. included 120 patients diagnosed with 125 healthy individuals. Peripheral blood samples were collected from all subjects EDTA tubes DNA extraction performed by salting out. Polymorphisms determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
Abstract Chemotherapy drugs efficiently eradicate rapidly dividing differentiated cells by inducing cell death, but poorly target slowly cells, including cancer stem and dormant in the later course of treatment. Prolonged exposure to chemotherapy results a decrease proportion apoptotic tumour mass. To investigate characterize molecular basis this phenomenon, microarray-based expression analysis was performed compare tHcred 2 -DEVD-EGFP-caspase 3-sensor transfected C-26 that were harvested...
We aimed to evaluate the association between TP53 Arg72Pro gene polymorphism and risk of colorectal cancer in an Azerbaijani population.A total 141 patients with 150 gender- age-matched controls were involved study. The genotypes detected by polymerase chain reaction-based restriction fragment length analysis.We found that heterozygous Arg/Pro (odds ratio, 1.128; 95% CI, 0.657-1.937) mutant Pro/Pro 1.274; 0.648-2.504) more frequent compared healthy controls. frequency Pro allele 1.122;...
Objective: The main aim of the present study was to determine clinical significance DNA methyltransferase 3B (DNMT3B) gene –579 G>T polymorphism in colorectal cancer (CRC) patients. Methods: A total 140 patients with CRC and 164 healthy individuals were included study. According manufacturer’s instructions, isolated from blood, genotypes determined on agarose gel by PCR-RFLP method. Genotype confirmation performed using Sanger sequencing randomly selected samples. Results: When comparing...
Background: Aortic dissection (AD) is a life-threatening cardiovascular disease. Pathophysiologically, it has been shown that aortic wall inflammation promotes the occurrence and development of dissection. Thus, aim current research was to determine inflammation-related biomarkers in AD. Methods: In this study, we conducted differentially expressed genes (DEGs) analysis using GSE153434 dataset containing 10 type A (TAAD) normal samples downloaded from Gene Expression Omnibus (GEO) database....
Background: Understanding the relationships between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism, colorectal polyps, and CRC risk can aid in advancing personalized medicine approaches prevention. The aim of current study is to identify association C677T polymorphism MTHFR with polyps Azerbaijani population. Methods: This included 125 patients colon 155 healthy individuals as a control group. DNA was extracted from venous blood samples obtained individuals, results were...