A5000964272- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Mindfulness and Compassion Interventions
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Neuroscience, Education and Cognitive Function
- Treatment of Major Depression
- Pharmacogenetics and Drug Metabolism
- Pain Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
Myriad Genetics
2020
Marquette University
2010-2018
Vanderbilt University
2017-2018
Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems poorly understood. Studies suggest that stress may "set stage" for increasing sensitivity of brain reward circuits drug-associated stimuli. We examined effects and corticosterone on behavioral neurochemical responses rats a prime after self-administration extinction. Exposure acute electric footshock did not itself reinstate drug-seeking...
The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, vBNST, corticotropin releasing factor (CRF) is expressed neurons that innervate tegmental area (VTA), a site where CRF receptor antagonist antalarmin prevents reinstatement seeking by stressor, intermittent footshock, following intravenous self-administration rats. vBNST receives dense noradrenergic innervation and expresses β adrenergic receptors (ARs)....
Stress can trigger the relapse of drug use in recovering cocaine addicts and reinstatement rodent models through mechanisms that may involve norepinephrine release β-adrenergic receptor activation. The present study examined role subtypes stressor-induced extinguished cocaine-induced (15 mg/kg i.p.) conditioned place preference mice. Forced swim (6 min at 22°C) stress or activation central noradrenergic neurotransmission by administration selective α<sub>2</sub> adrenergic antagonist...
The ability of stress to trigger cocaine seeking in humans and rodents is variable determined by the amount pattern prior drug use. This study examined role a corticotropin releasing factor (CRF)-regulated dopaminergic projection from ventral tegmental area (VTA) prelimbic cortex shock-induced its recruitment under self-administration conditions that establish relapse vulnerability. Male rats with history daily long-access (LgA; 14 × 6 h/d) but not short-access (ShA; 2 showed robust seeking....